AutismKB 2.0

Annotation Detail for PTPRB


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Basic Information Top
Gene Symbol:PTPRB ( DKFZp686E2262,DKFZp686H15164,FLJ44133,HPTP-BETA,HPTPB,MGC142023,MGC59935,PTPB,R-PTP-BETA,VEPTP )
Gene Full Name: protein tyrosine phosphatase, receptor type, B
Band: 12q15
Quick LinksEntrez ID:5787; OMIM: 176882; Uniprot ID:PTPRB_HUMAN; ENSEMBL ID: ENSG00000127329; HGNC ID: 9665
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
28N-linked (GlcNAc...) (Potential).
53N-linked (GlcNAc...) (Potential).
75N-linked (GlcNAc...) (Potential).
172N-linked (GlcNAc...) (Potential).
198N-linked (GlcNAc...) (Potential).
267N-linked (GlcNAc...) (Potential).
321N-linked (GlcNAc...) (Potential).
414N-linked (GlcNAc...) (Potential).
421N-linked (GlcNAc...) (Potential).
479N-linked (GlcNAc...) (Potential).
544N-linked (GlcNAc...) (Potential).
574N-linked (GlcNAc...) (Potential).
598N-linked (GlcNAc...) (Potential).
652N-linked (GlcNAc...) (Potential).
721N-linked (GlcNAc...) (Potential).
829N-linked (GlcNAc...) (Potential).
1040N-linked (GlcNAc...) (Potential).
1067Phosphothreonine.
1069Phosphoserine.
1096N-linked (GlcNAc...) (Potential).
1163N-linked (GlcNAc...) (Potential).
1185N-linked (GlcNAc...) (Potential).
1212N-linked (GlcNAc...) (Potential).
1274N-linked (GlcNAc...) (Potential).
1367N-linked (GlcNAc...) (Potential).
1470N-linked (GlcNAc...) (Potential).
1474N-linked (GlcNAc...) (Potential).
1518N-linked (GlcNAc...) (Potential).
1647Phosphoserine.
Location(AA) Modifications Resource
28N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
53N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
75N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
172N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
198N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
267N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
321N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
414N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
421N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
479N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
544N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
574N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
598N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
652N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
721N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
829N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1040N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1067Phosphothreonine.Swiss-Prot 53.0
1067PhosphothreoninePhospho.ELM 6.0
1069Phosphoserine.Swiss-Prot 53.0
1069PhosphoserinePhospho.ELM 6.0
1096N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1163N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1185N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1212N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1274N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1367N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1470N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1474N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1518N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1647Phosphoserine.Swiss-Prot 53.0
1647PhosphoserinePhospho.ELM 6.0
Location(AA) Modification Resource
28N-linkedHMM predict
40Phosphoserine(CK1)HMM predict
40Phosphoserine(IKK)HMM predict
75N-linkedHMM predict
81N-linkedHMM predict
135Phosphoserine(CDC2)HMM predict
192Phosphoserine(PKG)HMM predict
194Phosphoserine(CK1)HMM predict
196Phosphotyrosine(INSR)HMM predict
198N-linkedHMM predict
200O-linkedHMM predict
204Phosphoserine(CDC2)HMM predict
267N-linkedHMM predict
321N-linkedHMM predict
329Phosphothreonine(PKC)HMM predict
421N-linkedHMM predict
431Phosphotyrosine(Abl)HMM predict
479N-linkedHMM predict
544N-linkedHMM predict
574N-linkedHMM predict
598N-linkedHMM predict
602Phosphoserine(CK1)HMM predict
603Phosphoserine(CK1)HMM predict
603Phosphoserine(CK2)HMM predict
620O-linkedHMM predict
644O-linkedHMM predict
644O-linkedHMM predict
652N-linkedHMM predict
653N-linkedHMM predict
657N-linkedHMM predict
659Phosphotyrosine(INSR)HMM predict
659Phosphotyrosine(Syk)HMM predict
674Phosphotyrosine(Syk)HMM predict
698O-linkedHMM predict
703Phosphothreonine(MAPK)HMM predict
721N-linkedHMM predict
725Phosphoserine(CK1)HMM predict
745Phosphoserine(PKA)HMM predict
747Phosphotyrosine(Syk)HMM predict
777Phosphoserine(IKK)HMM predict
801O-linkedHMM predict
807Phosphotyrosine(INSR)HMM predict
829N-linkedHMM predict
832Phosphothreonine(PKA)HMM predict
879Phosphothreonine(MAPK)HMM predict
927N-linkedHMM predict
946Phosphoserine(ATM)HMM predict
982Phosphoserine(IKK)HMM predict
1008Phosphoserine(CK1)HMM predict
1040N-linkedHMM predict
1047Phosphothreonine(PKC)HMM predict
1079Phosphothreonine(PKC)HMM predict
1096N-linkedHMM predict
1182O-linkedHMM predict
1185N-linkedHMM predict
1193N-linkedHMM predict
1194C-linkedHMM predict
1204Phosphotyrosine(Syk)HMM predict
1212N-linkedHMM predict
1218N-linkedHMM predict
1259O-linkedHMM predict
1262Phosphoserine(MAPK)HMM predict
1262Phosphoserine(CDC2)HMM predict
1290Phosphotyrosine(Syk)HMM predict
1342Phosphothreonine(PKC)HMM predict
1367N-linkedHMM predict
1421Phosphotyrosine(Jak)HMM predict
1470N-linkedHMM predict
1474N-linkedHMM predict
1577Phosphotyrosine(Jak)HMM predict
1707Phosphotyrosine(Syk)HMM predict
1707Phosphotyrosine(Jak)HMM predict
1747Phosphoserine(PKG)HMM predict
1759N-linkedHMM predict
1825SulfotyrosineHMM predict
1865SulfotyrosineHMM predict
1953SulfotyrosineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_002837
  • Location:chr12 69201231-69289890
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Rb GrowingGSE19898 69300278 69300411 133 10454
hScc1 BcellGSE12603 69289972 69290307 335 249
hScc1 G2GSE9613 69289651 69290385 734 128
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Fos K562GSE19551 69187528 69187860 332 13538
Nanog ESGSE20650 69187487 69188014 527 13481
Nanog hESGSE18292 69187608 69188031 423 13412
Sox2 hESGSE18292 69187548 69187868 320 13524
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 69257121 69257392 271 0
CTCF CD4GSE12889 69270030 69270302 272 0
CTCF CD4SISSRdata 69257121 69257392 271 0
CTCF CD4SISSRdata 69270030 69270302 272 0
CTCF JurkatGSE12889 69270081 69270371 290 0
CTCF G2GSE9613 69257032 69257391 359 0
CTCF G2GSE9613 69269909 69270449 540 0
CTCF G2GSE9613 69289392 69290385 993 0
FOXA1 DLD1GSE12801 69228582 69229012 430 0
FOXA1 DLD1GSE12801 69229469 69230438 969 0
FOXA1 DLD1GSE12801 69231246 69231604 358 0
FOXA1 DLD1GSE12801 69233429 69234213 784 0
FOXA1 MCF7GSE15244 69233393 69234060 667 0
FOXA1 MCF7GSE15244 69237637 69237921 284 0
KLF4 hESGSE17917 69256618 69256777 159 0
P300 T30-glioblastomaGSE21026 69223343 69224080 737 0
Rb GrowingGSE19898 69262489 69262649 160 0
STAT1 HeLaGSE12783 69223200 69224175 975 0
STAT1 IFNSISSRdata 69223299 69224142 843 0
TFAP2C MCF7GSE21234 69264356 69264654 298 0
hScc1 BcellGSE12603 69256870 69257465 595 0
hScc1 BcellGSE12603 69269936 69270449 513 0
hScc1 CdLSGSE12603 69256802 69257609 807 0
hScc1 CdLSGSE12603 69270052 69270522 470 0
hScc1 G2GSE9613 69256870 69257465 595 0
hScc1 G2GSE9613 69269839 69270449 610 0
Validated miRNA targets Top
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
6301 mRNA chr12 69148131 69218858 77 mRNA PTPRB chr12 69201230 69289891Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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