AutismKB 2.0

Annotation Detail for PTPRF


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Basic Information Top
Gene Symbol:PTPRF ( FLJ43335,FLJ45062,FLJ45567,LAR )
Gene Full Name: protein tyrosine phosphatase, receptor type, F
Band: 1p34.2
Quick LinksEntrez ID:5792; OMIM: 179590; Uniprot ID:PTPRF_HUMAN; ENSEMBL ID: ENSG00000142949; HGNC ID: 9670
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
117N-linked (GlcNAc...) (Potential).
250N-linked (GlcNAc...) (Potential).
295N-linked (GlcNAc...) (Potential).
721N-linked (GlcNAc...) (Potential).
959N-linked (GlcNAc...).
966N-linked (GlcNAc...).
Location(AA) Modifications Resource
107N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
240N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
285N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
711N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
956N-linked (GlcNAc...).Swiss-Prot 53.0
Location(AA) Modification Resource
95Phosphotyrosine(EGFR)HMM predict
113Phosphoserine(PKG)HMM predict
190Phosphoserine(CK2)HMM predict
207Phosphotyrosine(Abl)HMM predict
225O-linkedHMM predict
230Phosphoserine(ATM)HMM predict
240N-linkedHMM predict
263Phosphothreonine(CK2)HMM predict
285N-linkedHMM predict
304Phosphothreonine(PKC)HMM predict
304O-linkedHMM predict
320O-linkedHMM predict
405Phosphoserine(CDC2)HMM predict
405Phosphoserine(CDK)HMM predict
440Phosphotyrosine(Syk)HMM predict
490Phosphoserine(MAPK)HMM predict
490Phosphoserine(CDC2)HMM predict
514Phosphoserine(CK1)HMM predict
554O-linkedHMM predict
595O-linkedHMM predict
595Phosphothreonine(MAPK)HMM predict
597O-linkedHMM predict
597Phosphoserine(PKA)HMM predict
616Phosphoserine(PKG)HMM predict
687O-linkedHMM predict
711N-linkedHMM predict
737Phosphothreonine(PKC)HMM predict
770Phosphotyrosine(EGFR)HMM predict
770SulfotyrosineHMM predict
770Phosphotyrosine(INSR)HMM predict
770Phosphotyrosine(Syk)HMM predict
778Phosphothreonine(MAPK)HMM predict
778O-linkedHMM predict
782O-linkedHMM predict
783Phosphotyrosine(SRC)HMM predict
783Phosphotyrosine(Abl)HMM predict
784O-linkedHMM predict
784Phosphoserine(SRC)HMM predict
786O-linkedHMM predict
786Phosphothreonine(PKC)HMM predict
919O-linkedHMM predict
956N-linkedHMM predict
964Phosphothreonine(PKA)HMM predict
990Phosphoserine(CDC2)HMM predict
990Phosphoserine(MAPK)HMM predict
990Phosphoserine(IKK)HMM predict
1063Phosphotyrosine(SRC)HMM predict
1143Phosphothreonine(CDK)HMM predict
1205Phosphoserine(MAPK)HMM predict
1230Phosphoserine(ATM)HMM predict
1230Phosphoserine(CDC2)HMM predict
1241O-linkedHMM predict
1241Phosphothreonine(MAPK)HMM predict
1279Phosphothreonine(PKA)HMM predict
1281Phosphoserine(CDC2)HMM predict
1281Phosphoserine(CAMK2)HMM predict
1281Phosphoserine(IKK)HMM predict
1281Phosphoserine(CDK)HMM predict
1284Phosphoserine(CK1)HMM predict
1284Phosphoserine(CK2)HMM predict
1301Phosphoserine(ATM)HMM predict
1343Phosphoserine(ATM)HMM predict
1346Phosphotyrosine(Syk)HMM predict
1395Phosphotyrosine(INSR)HMM predict
1587Phosphotyrosine(SRC)HMM predict
1643Phosphothreonine(PKC)HMM predict
1684Phosphotyrosine(INSR)HMM predict
1721N-linkedHMM predict
1874Phosphothreonine(CK2)HMM predict
1878Phosphotyrosine(SRC)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_130440
  • Location:chr1 43769133-43861928
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 43767449 43767798 349 1510
CTCF CD4SISSRdata 43767449 43767798 349 1510
CTCF G2GSE9613 43764095 43764263 168 4955
CTCF G2GSE9613 43767253 43767795 542 1610
ER Fulvestrant-MCF7GSE14664 43754642 43754678 36 14474
Fos K562GSE19551 43749603 43750126 523 19269
Gata1 K562GSE18868 43760684 43761838 1154 7873
Gata2 K562GSE18868 43760831 43761812 981 7812
H3ac HepG2E 43768013 43769016 1003 619
Nanog hESGSE18292 43753392 43753625 233 15625
Oct1 H2O2-HelaGSE14283 43768790 43768818 28 330
Oct1 HelaGSE14283 43754644 43754674 30 14475
Oct1 HelaGSE14283 43768790 43768819 29 329
Rb SenescentGSE19898 43767452 43767790 338 1513
TAF HelaGSE8489 43768224 43768976 752 534
TFAP2C MCF7GSE21234 43759216 43759553 337 9749
USF1 HepG2E 43766751 43768776 2025 1370
USF2 HepG2E 43766894 43768666 1772 1354
hScc1 BcellGSE12603 43767311 43767856 545 1550
hScc1 CdLSGSE12603 43767214 43768013 799 1520
hScc1 G2GSE9613 43767311 43767820 509 1568
p130 SenescentGSE19898 43767522 43767894 372 1426
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 43863787 43864101 314 2016
NRSF JurkatGSE13047 43870289 43870790 501 8611
NRSF JurkatSISSRdata 43863754 43863976 222 1937
NRSF JurkatSISSRdata 43870501 43870665 164 8655
NRSF mAbJurkat 43872730 43873363 633 11118
NRSF-mono JurkatQuESTdata 43870301 43870657 356 8551
NRSF-poly JurkatQuESTdata 43870353 43870719 366 8608
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 43792787 43792961 174 0
CTCF CD4SISSRdata 43792787 43792961 174 0
CTCF G2GSE9613 43769318 43770286 968 0
CTCF G2GSE9613 43787521 43787793 272 0
CTCF G2GSE9613 43788149 43788360 211 0
CTCF G2GSE9613 43791989 43793039 1050 0
CTCF G2GSE9613 43796734 43796947 213 0
CTCF G2GSE9613 43798253 43798997 744 0
CTCF G2GSE9613 43802799 43803139 340 0
CTCF G2GSE9613 43803820 43804358 538 0
CTCF G2GSE9613 43813307 43813614 307 0
CTCF G2GSE9613 43815455 43815838 383 0
CTCF G2GSE9613 43816380 43816840 460 0
CTCF G2GSE9613 43818987 43819442 455 0
CTCF G2GSE9613 43826838 43827157 319 0
CTCF G2GSE9613 43829696 43829979 283 0
CTCF G2GSE9613 43844285 43844580 295 0
CTCF G2GSE9613 43845211 43845732 521 0
CTCF G2GSE9613 43857711 43858448 737 0
CTCF G2GSE9613 43859795 43860302 507 0
ER MCF7E 43832278 43833022 744 0
Fos K562GSE19551 43820347 43820974 627 0
Fos K562GSE19551 43831304 43831642 338 0
GABP GMOGSE8489 43770059 43770495 436 0
GABP GMOGSE8489 43797455 43797939 484 0
GABP GMOGSE8489 43835026 43835676 650 0
GABP HepG2GSE8489 43797421 43797939 518 0
H3ac HepG2E 43770148 43771775 1627 0
H3ac HepG2E 43772209 43773945 1736 0
H3ac HepG2E 43774337 43774666 329 0
H3ac HepG2E 43777145 43777622 477 0
H3ac HepG2E 43782745 43783310 565 0
Nanog hESGSE18292 43773343 43773538 195 0
Oct1 HelaGSE14283 43800541 43800580 39 0
Oct1 HelaGSE14283 43837824 43837855 31 0
Rb SenescentGSE19898 43796713 43797083 370 0
Rb shRbSenescenceGSE19898 43803228 43803484 256 0
SRF GMOGSE8489 43769936 43770533 597 0
SRF GMOGSE8489 43797383 43797939 556 0
SRF GMOGSE8489 43798253 43798896 643 0
SRF GMOGSE8489 43835062 43835676 614 0
SRF HepG2GSE8489 43769936 43770533 597 0
SRF HepG2GSE8489 43797383 43797939 556 0
SRF HepG2GSE8489 43798253 43798896 643 0
SRF HepG2GSE8489 43834946 43835838 892 0
TFAP2C MCF7GSE21234 43774218 43775551 1333 0
TFAP2C MCF7GSE21234 43787943 43788914 971 0
TFAP2C MCF7GSE21234 43795747 43796495 748 0
TFAP2C MCF7GSE21234 43815781 43816896 1115 0
USF2 HepG2E 43786291 43787076 785 0
hScc1 BcellGSE12603 43769318 43770394 1076 0
hScc1 BcellGSE12603 43788284 43788631 347 0
hScc1 BcellGSE12603 43796575 43797029 454 0
hScc1 BcellGSE12603 43802362 43802535 173 0
hScc1 BcellGSE12603 43803966 43804276 310 0
hScc1 BcellGSE12603 43824558 43824805 247 0
hScc1 BcellGSE12603 43830616 43831110 494 0
hScc1 BcellGSE12603 43839532 43840117 585 0
hScc1 BcellGSE12603 43841340 43841845 505 0
hScc1 BcellGSE12603 43843196 43843478 282 0
hScc1 BcellGSE12603 43853505 43853788 283 0
p130 SenescentGSE19898 43796699 43797160 461 0
p130 SenescentGSE19898 43797489 43797895 406 0
p130 SenescentGSE19898 43803292 43803533 241 0
p130 shRbSenescentGSE19898 43803299 43803490 191 0
p63 keratinocytesGSE17611 43802466 43803259 793 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-let-7b hsa-let-7b 22 18668040
hsa-let-7b* hsa-let-7b 22 18668040
hsa-miR-1 hsa-mir-1-2 18 18668040
hsa-miR-1 hsa-mir-1-1 20 18668040
hsa-miR-155 hsa-mir-155 21 18668040
hsa-miR-155* hsa-mir-155 21 18668040
hsa-miR-16 hsa-mir-16-1 13 18668040
hsa-miR-16 hsa-mir-16-2 3 18668040
hsa-miR-30a hsa-mir-30a 6 18668040
hsa-miR-30a* hsa-mir-30a 6 18668040
hsa-miR-30b hsa-mir-30b 8 18668040
hsa-miR-30b* hsa-mir-30b 8 18668040
hsa-miR-30c hsa-mir-30c-2 6 18668040
hsa-miR-30c hsa-mir-30c-1 1 18668040
hsa-miR-30c-1* hsa-mir-30c-1 1 18668040
hsa-miR-30c-2* hsa-mir-30c-2 6 18668040
hsa-miR-30d hsa-mir-30d 8 18668040
hsa-miR-30d* hsa-mir-30d 8 18668040
hsa-miR-30e hsa-mir-30e 1 18668040
hsa-miR-30e* hsa-mir-30e 1 18668040
ID in Tarbase Data Type Support Type miRNA Gene Direct Support Publication
1190 Unknown pSILAC miR-1 PTPRF down 50-25% 18668040
Ensembl Protein Type Differentially expressed in Pathology or Event Mis Regulation Gene Expression Tumour Involvement
ENSG00000142949 n_a n_a n_a "epithelium, lymphocyte, muscle cell" "benign tumour, malignant tumour, carcinoma, leukaemia, sarcoma"
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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