AutismKB 2.0

Annotation Detail for PTPRJ


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Basic Information Top
Gene Symbol:PTPRJ ( CD148,DEP1,HPTPeta,R-PTP-ETA,SCC1 )
Gene Full Name: protein tyrosine phosphatase, receptor type, J
Band: 11p11.2
Quick LinksEntrez ID:5795; OMIM: 600925; Uniprot ID:PTPRJ_HUMAN; ENSEMBL ID: ENSG00000149177; HGNC ID: 9673
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
72N-linked (GlcNAc...) (Potential).
82N-linked (GlcNAc...) (Potential).
93N-linked (GlcNAc...) (Potential).
104N-linked (GlcNAc...) (Potential).
142N-linked (GlcNAc...) (Potential).
172N-linked (GlcNAc...) (Potential).
192N-linked (GlcNAc...) (Potential).
231N-linked (GlcNAc...) (Potential).
258N-linked (GlcNAc...) (Potential).
278N-linked (GlcNAc...) (Potential).
342N-linked (GlcNAc...).
351N-linked (GlcNAc...).
376N-linked (GlcNAc...) (Potential).
391N-linked (GlcNAc...).
396N-linked (GlcNAc...).
413N-linked (GlcNAc...).
431N-linked (GlcNAc...) (Potential).
501N-linked (GlcNAc...) (Potential).
525N-linked (GlcNAc...) (Potential).
536N-linked (GlcNAc...) (Potential).
582N-linked (GlcNAc...) (Potential).
603N-linked (GlcNAc...) (Potential).
618N-linked (GlcNAc...) (Potential).
628N-linked (GlcNAc...) (Potential).
637N-linked (GlcNAc...) (Potential).
666N-linked (GlcNAc...) (Potential).
669N-linked (GlcNAc...) (Potential).
761N-linked (GlcNAc...) (Potential).
772N-linked (GlcNAc...) (Potential).
784N-linked (GlcNAc...) (Potential).
790N-linked (GlcNAc...) (Potential).
824N-linked (GlcNAc...) (Potential).
910N-linked (GlcNAc...) (Potential).
937N-linked (GlcNAc...).
1011Phosphoserine (By similarity).
Location(AA) Modifications Resource
72N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
82N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
93N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
104N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
142N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
172N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
192N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
231N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
258N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
278N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
342N-linked (GlcNAc...).Swiss-Prot 53.0
351N-linked (GlcNAc...).Swiss-Prot 53.0
376N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
391N-linked (GlcNAc...).Swiss-Prot 53.0
396N-linked (GlcNAc...).Swiss-Prot 53.0
413N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
431N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
501N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
525N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
536N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
582N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
603N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
618N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
628N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
637N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
666N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
669N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
761N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
772N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
784N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
790N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
824N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
910N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
937N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
Location(AA) Modification Resource
41O-linkedHMM predict
47O-linkedHMM predict
72N-linkedHMM predict
82N-linkedHMM predict
84Phosphoserine(CK2)HMM predict
90Phosphoserine(CK2)HMM predict
93N-linkedHMM predict
98Phosphothreonine(CDC2)HMM predict
98Phosphothreonine(CDK)HMM predict
104N-linkedHMM predict
110Phosphoserine(ATM)HMM predict
113Phosphothreonine(CDK)HMM predict
113O-linkedHMM predict
113Phosphothreonine(MAPK)HMM predict
115Phosphoserine(CDC2)HMM predict
116O-linkedHMM predict
120Phosphoserine(CDC2)HMM predict
131Phosphoserine(CDC2)HMM predict
142N-linkedHMM predict
172N-linkedHMM predict
182Phosphotyrosine(Jak)HMM predict
192N-linkedHMM predict
231N-linkedHMM predict
258N-linkedHMM predict
278N-linkedHMM predict
296Phosphothreonine(PKC)HMM predict
299O-linkedHMM predict
303O-linkedHMM predict
303Phosphoserine(IKK)HMM predict
303Phosphoserine(CDC2)HMM predict
303PhosphoserineHMM predict
321O-linkedHMM predict
341Phosphotyrosine(Abl)HMM predict
342N-linkedHMM predict
346Phosphotyrosine(Abl)HMM predict
351N-linkedHMM predict
376N-linkedHMM predict
391N-linkedHMM predict
393Phosphoserine(CK1)HMM predict
396N-linkedHMM predict
413N-linkedHMM predict
431N-linkedHMM predict
458O-linkedHMM predict
525N-linkedHMM predict
536N-linkedHMM predict
582N-linkedHMM predict
603N-linkedHMM predict
618N-linkedHMM predict
628N-linkedHMM predict
631N-linkedHMM predict
637N-linkedHMM predict
638O-linkedHMM predict
666N-linkedHMM predict
668O-linkedHMM predict
669N-linkedHMM predict
714Phosphoserine(IKK)HMM predict
761N-linkedHMM predict
770Phosphoserine(IKK)HMM predict
770Phosphoserine(CK1)HMM predict
772N-linkedHMM predict
776Phosphotyrosine(Abl)HMM predict
776Phosphotyrosine(EGFR)HMM predict
784N-linkedHMM predict
790N-linkedHMM predict
808O-linkedHMM predict
824N-linkedHMM predict
876MethyllysineHMM predict
895Phosphoserine(ATM)HMM predict
897Phosphoserine(IKK)HMM predict
910N-linkedHMM predict
937N-linkedHMM predict
954Phosphotyrosine(EGFR)HMM predict
965Phosphoserine(IKK)HMM predict
1011Phosphoserine(ATM)HMM predict
1085Phosphoserine(PKG)HMM predict
1094SulfotyrosineHMM predict
1094Phosphotyrosine(INSR)HMM predict
1099Phosphotyrosine(INSR)HMM predict
1288Phosphotyrosine(SRC)HMM predict
1313N-linkedHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_002843
  • Location:chr11 47958688-48146245
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 47942133 47942274 141 16485
CTCF CD4SISSRdata 47942133 47942274 141 16485
FOXA1 DLD1GSE12801 47952281 47952707 426 6195
FOXA1 MCF7GSE15244 47955696 47955979 283 2851
Fos K562GSE19551 47939403 47939893 490 19041
Sox2 hESGSE18292 47952468 47952810 342 6050
hScc1 BcellGSE12603 47958406 47958944 538 14
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 48151072 48151234 162 4908
CTCF CD4SISSRdata 48151072 48151234 162 4908
CTCF JurkatGSE12889 48150996 48151263 267 4884
Myc K562GSE19551 48151017 48151346 329 4936
hScc1 BcellGSE12603 48150966 48151315 349 4895
hScc1 CdLSGSE12603 48150966 48151315 349 4895
hScc1 G2GSE9613 48150966 48151315 349 4895
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 47998217 47998541 324 0
CTCF CD4GSE12889 48088062 48088415 353 0
CTCF CD4SISSRdata 47998217 47998541 324 0
CTCF CD4SISSRdata 48088062 48088415 353 0
FOXA1 DLD1GSE12801 48033602 48034338 736 0
FOXA1 DLD1GSE12801 48066464 48066862 398 0
FOXA1 MCF7GSE15244 48020055 48020572 517 0
FOXA1 MCF7GSE15244 48030152 48031067 915 0
FOXA1 MCF7GSE15244 48033672 48034338 666 0
FOXA1 MCF7GSE15244 48124356 48124622 266 0
Fos K562GSE19551 47971412 47971978 566 0
Fos K562GSE19551 48062416 48063096 680 0
Gata1 K562GSE18868 48039302 48040039 737 0
Gata2 K562GSE18868 48033223 48033833 610 0
Gata2 K562GSE18868 48039333 48039948 615 0
KLF4 hESGSE17917 47978187 47978350 163 0
Myc K562GSE19551 47974408 47974748 340 0
Myc K562GSE19551 48039320 48039948 628 0
NFkBII GM12878GSE19485 47986803 47987855 1052 0
NRSF JurkatGSE13047 48068750 48069109 359 0
NRSF-mono JurkatQuESTdata 48068759 48069108 349 0
NRSF pAbJurkat 47991727 47991909 182 0
NRSF pAbJurkat 48018222 48018685 463 0
NRSF pAbJurkat 48057612 48058165 553 0
Nanog hESGSE18292 48088175 48088325 150 0
Oct1 HelaGSE14283 48007315 48007345 30 0
Oct1 HelaGSE14283 48015269 48015296 27 0
Oct1 HelaGSE14283 48105605 48105636 31 0
Oct1 HelaGSE14283 48105664 48105710 46 0
Oct1 HelaGSE14283 48107325 48107365 40 0
Oct1 HelaGSE14283 48119406 48119440 34 0
P300 T30-glioblastomaGSE21026 48041327 48042525 1198 0
RARA MCF7GSE15244 48020055 48020501 446 0
RARA MCF7GSE15244 48030152 48030987 835 0
RARA MCF7GSE15244 48033768 48034267 499 0
RARA MCF7GSE15244 48041499 48042160 661 0
RARA MCF7GSE15244 48075314 48075635 321 0
RARA MCF7GSE15244 48124356 48124585 229 0
RARG MCF7GSE15244 47976863 47977143 280 0
RARG MCF7GSE15244 47979947 47980233 286 0
RARG MCF7GSE15244 48003365 48004265 900 0
RARG MCF7GSE15244 48020055 48020462 407 0
RARG MCF7GSE15244 48030152 48031102 950 0
RARG MCF7GSE15244 48033392 48034338 946 0
RARG MCF7GSE15244 48087834 48088288 454 0
Rb GrowingGSE19898 48016442 48016609 167 0
TFAP2C MCF7GSE21234 47989000 47989623 623 0
TFAP2C MCF7GSE21234 48003483 48003874 391 0
TFAP2C MCF7GSE21234 48064513 48064982 469 0
VDR GM10861-stimGSE22484 47981634 47985398 3764 0
hScc1 BcellGSE12603 47998242 47998583 341 0
hScc1 BcellGSE12603 48036710 48037213 503 0
hScc1 BcellGSE12603 48087834 48088288 454 0
hScc1 BcellGSE12603 48106039 48106189 150 0
hScc1 BcellGSE12603 48128651 48129061 410 0
hScc1 CdLSGSE12603 47984860 47985183 323 0
hScc1 CdLSGSE12603 47998065 47998714 649 0
hScc1 CdLSGSE12603 48087499 48088288 789 0
hScc1 G2GSE9613 48087024 48088288 1264 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-let-7b hsa-let-7b 22 18668040
hsa-let-7b* hsa-let-7b 22 18668040
hsa-miR-1 hsa-mir-1-2 18 18668040
hsa-miR-1 hsa-mir-1-1 20 18668040
hsa-miR-155 hsa-mir-155 21 18668040
hsa-miR-155* hsa-mir-155 21 18668040
hsa-miR-16 hsa-mir-16-1 13 18668040
hsa-miR-16 hsa-mir-16-2 3 18668040
hsa-miR-212 hsa-mir-212 17 20856931
hsa-miR-30a hsa-mir-30a 6 18668040
hsa-miR-30a* hsa-mir-30a 6 18668040
hsa-miR-30b hsa-mir-30b 8 18668040
hsa-miR-30b* hsa-mir-30b 8 18668040
hsa-miR-30c hsa-mir-30c-2 6 18668040
hsa-miR-30c hsa-mir-30c-1 1 18668040
hsa-miR-30c-1* hsa-mir-30c-1 1 18668040
hsa-miR-30c-2* hsa-mir-30c-2 6 18668040
hsa-miR-30d hsa-mir-30d 8 18668040
hsa-miR-30d* hsa-mir-30d 8 18668040
hsa-miR-30e hsa-mir-30e 1 18668040
hsa-miR-30e* hsa-mir-30e 1 18668040
ID in Tarbase Data Type Support Type miRNA Gene Direct Support Publication
992 Unknown pSILAC miR-155 PTPRJ down 75-50% 18668040
Ensembl Protein Type Differentially expressed in Pathology or Event Mis Regulation Gene Expression Tumour Involvement
ENSG00000149177 n_a n_a n_a "lymphocyte, muscle cell" "benign tumour, malignant tumour, carcinoma, leukaemia, sarcoma"
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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