AutismKB 2.0

Annotation Detail for PTPRK


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:PTPRK ( DKFZp686C2268,DKFZp779N1045,R-PTP-kappa )
Gene Full Name: protein tyrosine phosphatase, receptor type, K
Band: 6q22.33
Quick LinksEntrez ID:5796; OMIM: 602545; Uniprot ID:PTPRK_HUMAN; ENSEMBL ID: ENSG00000152894; HGNC ID: 9674
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
101N-linked (GlcNAc...) (Potential).
140N-linked (GlcNAc...) (Potential).
211N-linked (GlcNAc...) (Potential).
416N-linked (GlcNAc...).
424N-linked (GlcNAc...) (Potential).
436N-linked (GlcNAc...) (Potential).
462N-linked (GlcNAc...) (Potential).
552N-linked (GlcNAc...) (Potential).
586N-linked (GlcNAc...) (Potential).
590N-linked (GlcNAc...) (Potential).
607N-linked (GlcNAc...) (Potential).
690N-linked (GlcNAc...) (Potential).
805Phosphotyrosine.
858Phosphotyrosine.
Location(AA) Modifications Resource
101N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
140N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
211N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
416N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
424N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
436N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
462N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
552N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
586N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
590N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
607N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
690N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
Location(AA) Modification Resource
19Phosphoserine(MAPK)HMM predict
52SulfotyrosineHMM predict
52Phosphotyrosine(Syk)HMM predict
52Phosphotyrosine(EGFR)HMM predict
67Phosphotyrosine(SRC)HMM predict
101N-linkedHMM predict
140N-linkedHMM predict
179Phosphotyrosine(INSR)HMM predict
211N-linkedHMM predict
254Phosphoserine(PKC)HMM predict
268PhosphotyrosineHMM predict
278Phosphoserine(IKK)HMM predict
336Phosphoserine(IKK)HMM predict
373O-linkedHMM predict
416N-linkedHMM predict
424N-linkedHMM predict
436N-linkedHMM predict
478Phosphoserine(PKG)HMM predict
546Phosphothreonine(PKC)HMM predict
552N-linkedHMM predict
586N-linkedHMM predict
589O-linkedHMM predict
590N-linkedHMM predict
599Phosphotyrosine(INSR)HMM predict
599SulfotyrosineHMM predict
605Phosphoserine(IKK)HMM predict
607N-linkedHMM predict
609O-linkedHMM predict
642Phosphothreonine(PKC)HMM predict
690N-linkedHMM predict
826N-linkedHMM predict
833N-linkedHMM predict
891Phosphotyrosine(EGFR)HMM predict
940Phosphotyrosine(INSR)HMM predict
949Phosphotyrosine(Syk)HMM predict
967Phosphotyrosine(SRC)HMM predict
1006Phosphotyrosine(Syk)HMM predict
1028Phosphothreonine(PKC)HMM predict
1070Phosphoserine(PKG)HMM predict
1169N-linkedHMM predict
1229Phosphotyrosine(INSR)HMM predict
1279Phosphoserine(ATM)HMM predict
1319N-linkedHMM predict
1327Phosphotyrosine(Syk)HMM predict
1410Phosphothreonine(PKC)HMM predict
1414Phosphoserine(PKG)HMM predict
1427PhenylalanineHMM predict
1428PhenylalanineHMM predict
1429PhenylalanineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_002844
  • Location:chr6 128331624-128883415
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
H3ac HepG2E 128883841 128884190 349 600
P300 T0-glioblastomaGSE21026 128901631 128902257 626 18529
P300 T30-glioblastomaGSE21026 128901628 128902236 608 18517
hScc1 CdLSGSE12603 128883336 128883887 551 196
p130 QuiescentGSE19898 128883680 128883946 266 398
p130 SenescentGSE19898 128883587 128884053 466 405
p130 shRbSenescentGSE19898 128883610 128884037 427 408
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Oct1 HelaGSE14283 128324279 128324320 41 7325
Oct1 HelaGSE14283 128329433 128329464 31 2176
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP JurkatGSE17954 128334096 128335889 1793 0
CBP JurkatGSE17954 128855542 128857572 2030 0
CTCF G2GSE9613 128626606 128626899 293 0
CTCF G2GSE9613 128690731 128690936 205 0
CTCF G2GSE9613 128881844 128882118 274 0
CTCF G2GSE9613 128882358 128883841 1483 0
ER MCF7GSE19013 128706482 128707013 531 0
ER MCF7E 128610628 128610853 225 0
FoxA1 MCF7MACSdata 128334946 128335164 218 0
FoxA1 MCF7MACSdata 128507183 128507358 175 0
FoxA1 MCF7MACSdata 128871804 128872001 197 0
H3K4me3 colorectalcancer 128881082 128882186 1104 0
H3ac HepG2E 128849721 128849944 223 0
H3ac HepG2E 128862196 128862458 262 0
H3ac HepG2E 128867380 128867906 526 0
H3ac HepG2E 128868306 128869212 906 0
H3ac HepG2E 128869561 128870200 639 0
H3ac HepG2E 128879185 128883249 4064 0
IGF1R DFBGSE23792 128337293 128337885 592 0
Oct1 H2O2-HelaGSE14283 128356094 128356126 32 0
Oct1 H2O2-HelaGSE14283 128396910 128396937 27 0
Oct1 H2O2-HelaGSE14283 128462488 128462519 31 0
Oct1 H2O2-HelaGSE14283 128470062 128470090 28 0
Oct1 H2O2-HelaGSE14283 128493964 128493994 30 0
Oct1 H2O2-HelaGSE14283 128496889 128496916 27 0
Oct1 H2O2-HelaGSE14283 128558231 128558261 30 0
Oct1 H2O2-HelaGSE14283 128764374 128764406 32 0
Oct1 H2O2-HelaGSE14283 128794692 128794732 40 0
Oct1 HelaGSE14283 128346100 128346128 28 0
Oct1 HelaGSE14283 128356092 128356129 37 0
Oct1 HelaGSE14283 128381515 128381585 70 0
Oct1 HelaGSE14283 128402197 128402287 90 0
Oct1 HelaGSE14283 128474004 128474057 53 0
Oct1 HelaGSE14283 128493968 128493997 29 0
Oct1 HelaGSE14283 128728513 128728552 39 0
Oct1 HelaGSE14283 128734204 128734235 31 0
Oct1 HelaGSE14283 128794687 128794734 47 0
P300 T0-glioblastomaGSE21026 128494057 128495067 1010 0
PHF8 HeLaGSE20725 128882351 128884065 1714 0
RARA MCF7GSE15244 128334455 128335189 734 0
RARA MCF7GSE15244 128874105 128874428 323 0
RNAII Tamoxifen-MCF7GSE14664 128614595 128614693 98 0
Rb GrowingGSE19898 128854828 128855060 232 0
TAF k562GSE8489 128514790 128515543 753 0
TFAP2C MCF7GSE21234 128487568 128487885 317 0
USF2 HepG2E 128627114 128627287 173 0
hScc1 BcellGSE12603 128882464 128883738 1274 0
hScc1 CdLSGSE12603 128690695 128691167 472 0
hScc1 G2GSE9613 128881630 128883963 2333 0
p63 keratinocytesGSE17611 128588978 128589607 629 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-let-7b hsa-let-7b 22 18668040
hsa-let-7b* hsa-let-7b 22 18668040
hsa-miR-1 hsa-mir-1-2 18 18668040
hsa-miR-1 hsa-mir-1-1 20 18668040
hsa-miR-155 hsa-mir-155 21 18668040
hsa-miR-155* hsa-mir-155 21 18668040
hsa-miR-16 hsa-mir-16-1 13 18668040
hsa-miR-16 hsa-mir-16-2 3 18668040
hsa-miR-30a hsa-mir-30a 6 18668040
hsa-miR-30a* hsa-mir-30a 6 18668040
hsa-miR-30b hsa-mir-30b 8 18668040
hsa-miR-30b* hsa-mir-30b 8 18668040
hsa-miR-30c hsa-mir-30c-2 6 18668040
hsa-miR-30c hsa-mir-30c-1 1 18668040
hsa-miR-30c-1* hsa-mir-30c-1 1 18668040
hsa-miR-30c-2* hsa-mir-30c-2 6 18668040
hsa-miR-30d hsa-mir-30d 8 18668040
hsa-miR-30d* hsa-mir-30d 8 18668040
hsa-miR-30e hsa-mir-30e 1 18668040
hsa-miR-30e* hsa-mir-30e 1 18668040
ID in Tarbase Data Type Support Type miRNA Gene Direct Support Publication
1268 Unknown pSILAC miR-30 PTPRK down 50-25% 18668040
Ensembl Protein Type Differentially expressed in Pathology or Event Mis Regulation Gene Expression Tumour Involvement
ENSG00000152894 n_a n_a n_a n_a n_a
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
23153 HTC chr6 128390702 128449126 173 mRNA PTPRK chr6 128331624 128883416Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved