AutismKB 2.0

Annotation Detail for PTPRM


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Basic Information Top
Gene Symbol:PTPRM ( MGC166994,PTPRL1,R-PTP-MU,RPTPM,RPTPU,hR-PTPu )
Gene Full Name: protein tyrosine phosphatase, receptor type, M
Band: 18p11.23
Quick LinksEntrez ID:5797; OMIM: 176888; Uniprot ID:PTPRM_HUMAN; ENSEMBL ID: ENSG00000173482; HGNC ID: 9675
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
72N-linked (GlcNAc...) (Potential).
92N-linked (GlcNAc...) (Potential).
131N-linked (GlcNAc...).
249N-linked (GlcNAc...) (Potential).
406N-linked (GlcNAc...) (Potential).
414N-linked (GlcNAc...) (Potential).
454N-linked (GlcNAc...) (Potential).
534N-linked (GlcNAc...) (Potential).
544N-linked (GlcNAc...) (Potential).
598N-linked (GlcNAc...) (Potential).
651N-linked (GlcNAc...) (Potential).
681N-linked (GlcNAc...) (Potential).
821Phosphoserine.
824Phosphoserine.
Location(AA) Modifications Resource
72N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
92N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
131N-linked (GlcNAc...).Swiss-Prot 53.0
249N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
406N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
414N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
454N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
534N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
544N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
598N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
651N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
681N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
Location(AA) Modification Resource
38SulfotyrosineHMM predict
38Phosphotyrosine(Jak)HMM predict
72N-linkedHMM predict
92N-linkedHMM predict
109Phosphoserine(IKK)HMM predict
109Phosphoserine(CDC2)HMM predict
131N-linkedHMM predict
169Phosphotyrosine(Syk)HMM predict
169Phosphotyrosine(Jak)HMM predict
249N-linkedHMM predict
258Phosphotyrosine(INSR)HMM predict
365O-linkedHMM predict
365Phosphoserine(CDC2)HMM predict
397Phosphothreonine(PKC)HMM predict
406N-linkedHMM predict
414N-linkedHMM predict
448N-linkedHMM predict
454N-linkedHMM predict
470Phosphoserine(ATM)HMM predict
493Phosphoserine(CK2)HMM predict
510Phosphotyrosine(SRC)HMM predict
520Phosphotyrosine(Syk)HMM predict
534N-linkedHMM predict
540Phosphoserine(PKG)HMM predict
544N-linkedHMM predict
562Phosphothreonine(PKC)HMM predict
566Phosphoserine(PKG)HMM predict
584Phosphoserine(PKG)HMM predict
598N-linkedHMM predict
602N-linkedHMM predict
636Phosphothreonine(PKA)HMM predict
681N-linkedHMM predict
685N-linkedHMM predict
726O-linkedHMM predict
726Phosphothreonine(MAPK)HMM predict
776Phosphothreonine(PKA)HMM predict
778Phosphoserine(CK1)HMM predict
820Phosphoserine(IKK)HMM predict
820Phosphoserine(PKB)HMM predict
821Phosphoserine(MAPK)HMM predict
823O-linkedHMM predict
824O-linkedHMM predict
834O-linkedHMM predict
835O-linkedHMM predict
835Phosphoserine(IKK)HMM predict
853Phosphoserine(CK1)HMM predict
854Phosphoserine(CK1)HMM predict
854O-linkedHMM predict
854Phosphoserine(IKK)HMM predict
861Phosphotyrosine(Syk)HMM predict
861Phosphotyrosine(Jak)HMM predict
904Phosphotyrosine(EGFR)HMM predict
953Phosphotyrosine(INSR)HMM predict
958Phosphotyrosine(INSR)HMM predict
1019Phosphotyrosine(Syk)HMM predict
1084Phosphoserine(CDC2)HMM predict
1144Phosphotyrosine(SRC)HMM predict
1165Phosphoserine(IKK)HMM predict
1182N-linkedHMM predict
1242Phosphotyrosine(INSR)HMM predict
1340Phosphotyrosine(Syk)HMM predict
1423Phosphothreonine(PKC)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_002845
  • Location:chr18 7557816-8396851
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 7556704 7557571 867 679
ER MCF7GSE19013 7549912 7550393 481 7664
Myc hESGSE17917 7557021 7557520 499 546
hScc1 BcellGSE12603 7556669 7557722 1053 621
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 8415825 8416793 968 19458
NRSF JurkatGSE13047 8402243 8402579 336 5560
NRSF JurkatSISSRdata 8402295 8402486 191 5539
NRSF-mono JurkatQuESTdata 8402253 8402473 220 5512
NRSF-poly JurkatQuESTdata 8402195 8402579 384 5536
Oct1 H2O2-HelaGSE14283 8399676 8399706 30 2840
Oct1 HelaGSE14283 8399668 8399707 39 2836
TFAP2C MCF7GSE21234 8415229 8416205 976 18866
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T30-glioblastomaGSE21026 7935809 7936549 740 0
CTCF G2GSE9613 7558103 7558614 511 0
CTCF G2GSE9613 7774756 7775018 262 0
CTCF G2GSE9613 7970178 7970352 174 0
CTCF G2GSE9613 8379349 8380223 874 0
ER Breast-CancerGSE22609 7740892 7741405 513 0
ER E2-MCF7GSE14664 7672216 7672284 68 0
ER E2-MCF7GSE14664 8160533 8160577 44 0
ER Fulvestrant-MCF7GSE14664 7942648 7942685 37 0
ER Fulvestrant-MCF7GSE14664 8155893 8155983 90 0
ER Fulvestrant-MCF7GSE14664 8160533 8160576 43 0
Fos K562GSE19551 7820394 7820815 421 0
H3ac HepG2E 7559124 7559917 793 0
KLF4 hESGSE17917 7737628 7737783 155 0
Myc K562GSE19551 8379716 8379968 252 0
NRSF JurkatSISSRdata 7741033 7741202 169 0
NRSF-mono JurkatQuESTdata 8120226 8120502 276 0
Nanog ESGSE20650 7956649 7957041 392 0
Nanog hESGSE18292 7656234 7656492 258 0
Nanog hESGSE18292 8303041 8303447 406 0
Nanog hESGSE18292 8384603 8384994 391 0
Oct1 H2O2-HelaGSE14283 7826955 7826982 27 0
Oct1 H2O2-HelaGSE14283 7843486 7843531 45 0
Oct1 H2O2-HelaGSE14283 7851521 7851549 28 0
Oct1 H2O2-HelaGSE14283 7936240 7936268 28 0
Oct1 H2O2-HelaGSE14283 7987619 7987652 33 0
Oct1 H2O2-HelaGSE14283 8019677 8019715 38 0
Oct1 H2O2-HelaGSE14283 8137299 8137332 33 0
Oct1 H2O2-HelaGSE14283 8319105 8319133 28 0
Oct1 HelaGSE14283 7624931 7624961 30 0
Oct1 HelaGSE14283 8019678 8019714 36 0
Oct1 HelaGSE14283 8084424 8084458 34 0
Oct1 HelaGSE14283 8137297 8137334 37 0
Oct1 HelaGSE14283 8160545 8160584 39 0
Oct1 HelaGSE14283 8336910 8336951 41 0
P300 T30-glioblastomaGSE21026 7616578 7617602 1024 0
P300 T30-glioblastomaGSE21026 7802129 7802996 867 0
P300 T30-glioblastomaGSE21026 7911897 7912949 1052 0
P300 T30-glioblastomaGSE21026 7935674 7936513 839 0
P300 T30-glioblastomaGSE21026 8041980 8042729 749 0
PolII HeLaGSE12783 7940488 7941476 988 0
RNAII Tamoxifen-MCF7GSE14664 8102724 8102808 84 0
Rb SenescentGSE19898 7894633 7894917 284 0
STAT1 HeLaGSE12782 7860453 7863244 2791 0
STAT1 HeLaGSE12783 7859739 7863166 3427 0
Sox2 hESGSE18292 7656085 7656482 397 0
Sox2 hESGSE18292 8384628 8384920 292 0
Stat6 IL-4-hr1GSE17850 8265763 8266342 579 0
TFAP2C MCF7GSE21234 8152847 8153157 310 0
hScc1 BcellGSE12603 7558103 7558696 593 0
hScc1 BcellGSE12603 7970214 7970352 138 0
hScc1 BcellGSE12603 8019071 8019486 415 0
hScc1 BcellGSE12603 8352145 8352449 304 0
hScc1 BcellGSE12603 8379692 8380135 443 0
p63 keratinocytesGSE17611 7718130 7718838 708 0
p63 keratinocytesGSE17611 8363174 8364146 972 0
Validated miRNA targets Top
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
11906 mRNA PTPRM chr18 7744970 8396854 6147 EST chr18 8350817 8356964 Non-exonic Bidirectional (NOB) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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