AutismKB 2.0

Annotation Detail for PTPRS


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Basic Information Top
Gene Symbol:PTPRS ( PTPSIGMA )
Gene Full Name: protein tyrosine phosphatase, receptor type, S
Band: 19p13.3
Quick LinksEntrez ID:5802; OMIM: 601576; Uniprot ID:PTPRS_HUMAN; ENSEMBL ID: ENSG00000105426; HGNC ID: 9681
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
263N-linked (GlcNAc...) (Potential).
308N-linked (GlcNAc...) (Potential).
733N-linked (GlcNAc...).
940N-linked (GlcNAc...) (Potential).
Location(AA) Modifications Resource
263N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
308N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
733N-linked (GlcNAc...).Swiss-Prot 53.0
940N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
Location(AA) Modification Resource
98Phosphothreonine(MAPK)HMM predict
105Phosphotyrosine(Syk)HMM predict
105Phosphotyrosine(SRC)HMM predict
226Phosphotyrosine(Abl)HMM predict
228Phosphoserine(CDC2)HMM predict
263N-linkedHMM predict
308N-linkedHMM predict
309Phosphotyrosine(INSR)HMM predict
337Phosphothreonine(MAPK)HMM predict
414O-linkedHMM predict
463Phosphotyrosine(Syk)HMM predict
464SulfotyrosineHMM predict
537Phosphoserine(CK1)HMM predict
540Phosphoserine(IKK)HMM predict
552Phosphoserine(PKG)HMM predict
613Phosphothreonine(PKC)HMM predict
613Phosphothreonine(PKA)HMM predict
619Phosphoserine(PKA)HMM predict
709O-linkedHMM predict
733N-linkedHMM predict
805Phosphotyrosine(Abl)HMM predict
805Phosphotyrosine(SRC)HMM predict
843Phosphothreonine(CDC2)HMM predict
843Phosphothreonine(MAPK)HMM predict
876Phosphothreonine(MAPK)HMM predict
880O-linkedHMM predict
880Phosphothreonine(PKC)HMM predict
900Phosphothreonine(PKC)HMM predict
922Phosphoserine(CK1)HMM predict
927Phosphothreonine(CDC2)HMM predict
1014Phosphothreonine(PKC)HMM predict
1022Phosphoserine(CDC2)HMM predict
1060Phosphotyrosine(Abl)HMM predict
1060Phosphotyrosine(EGFR)HMM predict
1114O-linkedHMM predict
1228Phosphotyrosine(Syk)HMM predict
1348Phosphothreonine(CDC2)HMM predict
1355Phosphoserine(CDK)HMM predict
1355Phosphoserine(CDC2)HMM predict
1369Phosphoserine(ATM)HMM predict
1394Phosphoserine(ATM)HMM predict
1397Phosphotyrosine(INSR)HMM predict
1397Phosphotyrosine(Syk)HMM predict
1446Phosphotyrosine(INSR)HMM predict
1513Phosphotyrosine(SRC)HMM predict
1539N-linkedHMM predict
1638Phosphotyrosine(SRC)HMM predict
1694Phosphothreonine(PKC)HMM predict
1735Phosphotyrosine(INSR)HMM predict
1771N-linkedHMM predict
1772N-linkedHMM predict
1925Phosphothreonine(CK2)HMM predict
1929Phosphotyrosine(SRC)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_130854
  • Location:chr19 5156519-5291813
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF HelaGSE12889 5305626 5305763 137 13881
Fos K562GSE19551 5291654 5292283 629 155
NRSF JurkatGSE13047 5307190 5308000 810 15782
NRSF JurkatSISSRdata 5296922 5297225 303 5260
NRSF mAbJurkat 5305966 5306311 345 14325
NRSF mAbJurkat 5307177 5308653 1476 16102
NRSF mAbJurkat 5309717 5310266 549 18178
NRSF mAbJurkat 5311089 5311535 446 19499
NRSF-mono JurkatQuESTdata 5296779 5297304 525 5228
NRSF-mono JurkatQuESTdata 5307184 5307952 768 15755
NRSF-poly JurkatQuESTdata 5296747 5297283 536 5202
NRSF-poly JurkatQuESTdata 5307301 5307953 652 15814
Oct1 H2O2-HelaGSE14283 5299770 5299802 32 7973
Oct1 H2O2-HelaGSE14283 5305885 5305914 29 14086
Oct1 HelaGSE14283 5299762 5299802 40 7969
Oct1 HelaGSE14283 5303737 5303767 30 11939
PolII HeLaGSE12783 5303105 5304131 1026 11805
USF1 HepG2E 5292188 5292562 374 562
USF1 HepG2E 5293667 5293983 316 2012
USF2 HepG2E 5292242 5292562 320 589
USF2 HepG2E 5293667 5293983 316 2012
hScc1 BcellGSE12603 5295379 5295606 227 3679
p63 keratinocytesGSE17611 5296683 5297495 812 5276
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
ER E2-MCF7GSE14664 5150115 5150159 44 6383
Oct1 HelaGSE14283 5150114 5150155 41 6385
Sox2 hESGSE18292 5144400 5144757 357 11941
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T0-glioblastomaGSE21026 5223608 5223817 209 0
CTCF HelaGSE12889 5176983 5177334 351 0
CTCF G2GSE9613 5176876 5177307 431 0
CTCF G2GSE9613 5189827 5190086 259 0
CTCF G2GSE9613 5190894 5191216 322 0
CTCF G2GSE9613 5243450 5244522 1072 0
CTCF G2GSE9613 5273173 5273572 399 0
CTCF G2GSE9613 5283582 5283842 260 0
ER Breast-CancerGSE22609 5220848 5221300 452 0
ER Breast-CancerGSE22609 5265043 5265729 686 0
Fos K562GSE19551 5265120 5265503 383 0
KLF4 hESGSE17917 5201560 5202021 461 0
NFkBII GM10847GSE19485 5280756 5281783 1027 0
NFkBII GM12878GSE19485 5280932 5282191 1259 0
NFkBII GM12892GSE19485 5280751 5282004 1253 0
Oct1 H2O2-HelaGSE14283 5158602 5158634 32 0
Oct1 H2O2-HelaGSE14283 5277106 5277135 29 0
Oct1 HelaGSE14283 5156912 5156942 30 0
Oct1 HelaGSE14283 5158604 5158633 29 0
Oct1 HelaGSE14283 5162651 5162715 64 0
Oct1 HelaGSE14283 5197979 5198009 30 0
Oct1 HelaGSE14283 5277102 5277135 33 0
Oct4 hESGSE17917 5188490 5188915 425 0
PHF8 293TGSE20725 5243785 5244363 578 0
TAF HelaGSE8489 5159773 5161035 1262 0
TAF k562GSE8489 5159741 5161076 1335 0
TFAP2C MCF7GSE21234 5211738 5212809 1071 0
TFAP2C MCF7GSE21234 5249348 5250042 694 0
hScc1 BcellGSE12603 5173845 5174212 367 0
hScc1 BcellGSE12603 5177000 5177307 307 0
hScc1 BcellGSE12603 5195027 5195508 481 0
hScc1 BcellGSE12603 5239387 5239819 432 0
hScc1 BcellGSE12603 5240304 5240630 326 0
hScc1 BcellGSE12603 5246429 5246732 303 0
hScc1 BcellGSE12603 5250010 5250557 547 0
hScc1 BcellGSE12603 5260798 5261257 459 0
hScc1 BcellGSE12603 5273372 5273572 200 0
hScc1 BcellGSE12603 5276430 5276651 221 0
hScc1 BcellGSE12603 5288065 5288709 644 0
hScc1 BcellGSE12603 5291178 5291710 532 0
p130 SenescentGSE19898 5244693 5245275 582 0
Validated miRNA targets Top
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
12544 mRNA chr19 5129129 5129462 333 mRNA PTPRS chr19 5109505 5291814 Non-exonic Bidirectional (NOB) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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