Annotation Detail for PTBP2

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Basic Information Top

Gene Symbol:	PTBP2 ( FLJ34897,PTB,PTBLP,brPTB,nPTB,nPTB5,nPTB6,nPTB7,nPTB8 )
Gene Full Name:	polypyrimidine tract binding protein 2
Band:	1p21.3
Quick Links	Entrez ID:58155; OMIM: 608449; Uniprot ID:PTBP2_HUMAN; ENSEMBL ID: ENSG00000117569; HGNC ID: 17662
Relate to Another Database:	SFARIGene; denovo-db

Post Translation Modification

Location(AA)	Modification
1	N-acetylmethionine.
27	Phosphoserine (By similarity).
308	Phosphoserine (By similarity).

Location(AA)	Modifications	Resource
27	Phosphoserine (By similarity).	Swiss-Prot 53.0
308	Phosphoserine (By similarity).	Swiss-Prot 53.0

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
Oct1	Hela	GSE14283	96946214	96946275	61	13721
PHF8	Hs68plusFBS	GSE20725	96959158	96960631	1473	71
hScc1	Bcell	GSE12603	96959642	96960047	405	121

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length
CTCF	G2	GSE9613	96959642	96960413	771
H3K4me3	colorectal	cancer	96960689	96961885	1196
H3ac	HepG2	E	96960348	96961920	1572
Oct1	H2O2-Hela	GSE14283	96978167	96978215	48
Oct1	Hela	GSE14283	96978166	96978215	49
Rb	Growing	GSE19898	96960742	96960874	132
TAF	k562	GSE8489	96960725	96961990	1265

Validated miRNA targets

Micro RNA Name	Stem Loop Name	The chromosome that miRNA located	Publication
hsa-let-7b	hsa-let-7b	22	18668040
hsa-let-7b*	hsa-let-7b	22	18668040
hsa-miR-1	hsa-mir-1-2	18	18668040
hsa-miR-1	hsa-mir-1-1	20	18668040
hsa-miR-124	hsa-mir-124-1	8	21062284
hsa-miR-124	hsa-mir-124-2	8	21062284
hsa-miR-124	hsa-mir-124-3	20	21062284
hsa-miR-124	hsa-mir-124-1	8	17679093
hsa-miR-124	hsa-mir-124-2	8	17679093
hsa-miR-124	hsa-mir-124-3	20	17679093
hsa-miR-124*	hsa-mir-124-1	8	21062284
hsa-miR-133a	hsa-mir-133a-1	18	20520763
hsa-miR-133a	hsa-mir-133a-2	20	20520763
hsa-miR-133a	hsa-mir-133a-1	18	17210790
hsa-miR-133a	hsa-mir-133a-2	20	17210790
hsa-miR-133b	hsa-mir-133b	6	17210790
hsa-miR-146a	hsa-mir-146a	5	20520763
hsa-miR-146a*	hsa-mir-146a	5	20520763
hsa-miR-146b-3p	hsa-mir-146b	10	20520763
hsa-miR-146b-5p	hsa-mir-146b	10	20520763
hsa-miR-155	hsa-mir-155	21	18668040
hsa-miR-155*	hsa-mir-155	21	18668040
hsa-miR-16	hsa-mir-16-1	13	18668040
hsa-miR-16	hsa-mir-16-2	3	18668040
hsa-miR-206	hsa-mir-206	6	17210790
hsa-miR-30a	hsa-mir-30a	6	18668040
hsa-miR-30a*	hsa-mir-30a	6	18668040
hsa-miR-30b	hsa-mir-30b	8	18668040
hsa-miR-30b*	hsa-mir-30b	8	18668040
hsa-miR-30c	hsa-mir-30c-2	6	18668040
hsa-miR-30c	hsa-mir-30c-1	1	18668040
hsa-miR-30c-1*	hsa-mir-30c-1	1	18668040
hsa-miR-30c-2*	hsa-mir-30c-2	6	18668040
hsa-miR-30d	hsa-mir-30d	8	18668040
hsa-miR-30d*	hsa-mir-30d	8	18668040
hsa-miR-30e	hsa-mir-30e	1	18668040
hsa-miR-30e*	hsa-mir-30e	1	18668040

ID in Tarbase	Data Type	Support Type	miRNA	Gene	Direct Support	Publication
449	mRNA repression	TRUE	miR-133	PTBP2	in vitro reporter gene assay (Luciferase) AND immunoblotting	17210790
1186	Unknown	pSILAC	miR-1	PTBP2	down 50-25%	18668040
Ensembl	Protein Type	Differentially expressed in	Pathology or Event	Mis Regulation	Gene Expression	Tumour Involvement
ENSG00000117569		"cardiac and skeletal muscles, cardiogenesis"	n_a	n_a	"lymphoblast, lymphocyte, muscle cell"	"benign tumour, malignant tumour, carcinoma, leukaemia, sarcoma"
ENSG00000117569		n_a	n_a	n_a	"lymphoblast, lymphocyte, muscle cell"	"benign tumour, malignant tumour, carcinoma, leukaemia, sarcoma"

Cis-Nats regulation

Simple Query:

Paper Collected: 6/30/2018

Last Update: 8/26/2018