AutismKB 2.0

Annotation Detail for MLL3


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Basic Information Top
Gene Symbol:MLL3 ( DKFZp686C08112,FLJ12625,FLJ38309,HALR,KIAA1506,KMT2C,MGC119851,MGC119852,MGC119853 )
Gene Full Name: myeloid/lymphoid or mixed-lineage leukemia 3
Band: 7q36.1
Quick LinksEntrez ID:58508; OMIM: 606833; Uniprot ID:MLL3_HUMAN; ENSEMBL ID: ENSG00000055609; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
758N6-acetyllysine.
827N6-acetyllysine.
1508N6-acetyllysine.
1772N6-acetyllysine.
2009N6-acetyllysine.
2802N6-acetyllysine.
2809N6-acetyllysine.
2832N6-acetyllysine.
3714N6-acetyllysine.
3945N6-acetyllysine.
4018Phosphotyrosine.
4022Phosphoserine.
4034Phosphoserine.
4050Phosphoserine.
Location(AA) Modifications Resource
2809N6-acetyllysine.Swiss-Prot 53.0
4018Phosphotyrosine.Swiss-Prot 53.0
4018PhosphotyrosinePhospho.ELM 6.0
4022Phosphoserine.Swiss-Prot 53.0
4022PhosphoserinePhospho.ELM 6.0
Location(AA) Modification Resource
8Phosphoserine(CK1)HMM predict
8Phosphoserine(IKK)HMM predict
28O-linkedHMM predict
28Phosphoserine(CDC2)HMM predict
68Phosphoserine(CK1)HMM predict
89Phosphoserine(CK2)HMM predict
113Phosphoserine(CK2)HMM predict
119Phosphoserine(CK1)HMM predict
137S-palmitoylHMM predict
178N-linkedHMM predict
181Phosphotyrosine(INSR)HMM predict
181Phosphotyrosine(SRC)HMM predict
181Phosphotyrosine(Syk)HMM predict
338Phosphoserine(CK1)HMM predict
376Phosphothreonine(MAPK)HMM predict
376Phosphothreonine(CDK)HMM predict
447Phosphoserine(ATM)HMM predict
470S-palmitoylHMM predict
512Phosphotyrosine(INSR)HMM predict
542SulfotyrosineHMM predict
593Phosphoserine(CK2)HMM predict
598Phosphothreonine(CK2)HMM predict
678Phosphoserine(CK2)HMM predict
682Phosphoserine(PKA)HMM predict
730Phosphoserine(CK1)HMM predict
742Phosphothreonine(MAPK)HMM predict
769Phosphoserine(IKK)HMM predict
771Phosphoserine(CK1)HMM predict
771Phosphoserine(CK2)HMM predict
772Phosphoserine(CK2)HMM predict
782O-linkedHMM predict
783O-linkedHMM predict
783Phosphoserine(CK1)HMM predict
784Phosphoserine(CDC2)HMM predict
784Phosphoserine(CDK)HMM predict
784Phosphoserine(ATM)HMM predict
786O-linkedHMM predict
786O-linkedHMM predict
786Phosphothreonine(MAPK)HMM predict
786Phosphothreonine(CDK)HMM predict
805Phosphoserine(CK1)HMM predict
805Phosphoserine(CK2)HMM predict
836Phosphoserine(CAMK2)HMM predict
836Phosphoserine(CDC2)HMM predict
854O-linkedHMM predict
859PhosphoserineHMM predict
897MethylarginineHMM predict
907MethylarginineHMM predict
1043Phosphothreonine(PKC)HMM predict
1054S-palmitoylHMM predict
1074N-linkedHMM predict
1090S-palmitoylHMM predict
1119Phosphothreonine(CK2)HMM predict
1200Phosphoserine(PKA)HMM predict
1200Phosphoserine(PKG)HMM predict
1200PhosphoserineHMM predict
1219Phosphothreonine(MAPK)HMM predict
1228Phosphoserine(CK1)HMM predict
1250PhosphoserineHMM predict
1251Phosphoserine(CDC2)HMM predict
1298Phosphothreonine(PKC)HMM predict
1310Phosphoserine(CK1)HMM predict
1310Phosphoserine(IKK)HMM predict
1336Phosphoserine(CK1)HMM predict
1336Phosphoserine(CK2)HMM predict
1362SulfotyrosineHMM predict
1413Phosphoserine(CK1)HMM predict
1470O-linkedHMM predict
1470Phosphoserine(IKK)HMM predict
1477N-linkedHMM predict
1493Phosphoserine(MAPK)HMM predict
1536O-linkedHMM predict
1536Phosphothreonine(MAPK)HMM predict
1612N-linkedHMM predict
1613N-linkedHMM predict
1626N-linkedHMM predict
1631N-linkedHMM predict
1636Phosphothreonine(PKC)HMM predict
1686Phosphoserine(PKA)HMM predict
1686Phosphoserine(PKG)HMM predict
1712Phosphoserine(IKK)HMM predict
1745Phosphoserine(CK1)HMM predict
1801Phosphothreonine(MAPK)HMM predict
1803Phosphoserine(CK1)HMM predict
1804O-linkedHMM predict
1808Phosphoserine(CDC2)HMM predict
1808Phosphoserine(CDK)HMM predict
1836O-linkedHMM predict
1836O-linkedHMM predict
1836Phosphoserine(IKK)HMM predict
1837O-linkedHMM predict
1837O-linkedHMM predict
1837Phosphothreonine(MAPK)HMM predict
1837Phosphothreonine(CDK)HMM predict
1839O-linkedHMM predict
1840O-linkedHMM predict
1840O-linkedHMM predict
1840Phosphoserine(IKK)HMM predict
1841O-linkedHMM predict
1869Phosphoserine(CK1)HMM predict
1869Phosphoserine(ATM)HMM predict
1869Phosphoserine(IKK)HMM predict
1874O-linkedHMM predict
1874Phosphoserine(ATM)HMM predict
1874Phosphoserine(IKK)HMM predict
1878Phosphoserine(CDC2)HMM predict
1878Phosphoserine(MAPK)HMM predict
1878Phosphoserine(ATM)HMM predict
1883O-linkedHMM predict
1883Phosphoserine(CDC2)HMM predict
1883Phosphoserine(CDK)HMM predict
1889O-linkedHMM predict
1889Phosphoserine(PKA)HMM predict
1893Phosphoserine(CDC2)HMM predict
1893Phosphoserine(IKK)HMM predict
1919Phosphoserine(PKA)HMM predict
1919Phosphoserine(PKG)HMM predict
1925N-linkedHMM predict
1927Phosphothreonine(MAPK)HMM predict
1939N-linkedHMM predict
1944N-linkedHMM predict
1947Phosphoserine(CDC2)HMM predict
1955Phosphoserine(CK1)HMM predict
1963Phosphotyrosine(Abl)HMM predict
1963Phosphotyrosine(Syk)HMM predict
1969Phosphothreonine(MAPK)HMM predict
1987Phosphoserine(CDC2)HMM predict
1987Phosphoserine(ATM)HMM predict
2011Phosphoserine(CDC2)HMM predict
2032Phosphothreonine(MAPK)HMM predict
2045Phosphothreonine(CDC2)HMM predict
2052O-linkedHMM predict
2057Phosphotyrosine(Syk)HMM predict
2068Phosphoserine(PKA)HMM predict
2068Phosphoserine(PKC)HMM predict
2068Phosphoserine(PKG)HMM predict
2072Phosphotyrosine(Syk)HMM predict
2078Phosphothreonine(MAPK)HMM predict
2088N-linkedHMM predict
2091N-linkedHMM predict
2094Phosphotyrosine(SRC)HMM predict
2094Phosphotyrosine(Abl)HMM predict
2094Phosphotyrosine(Jak)HMM predict
2094Phosphotyrosine(Syk)HMM predict
2095O-linkedHMM predict
2095Phosphoserine(ATM)HMM predict
2100Phosphothreonine(MAPK)HMM predict
2106N-linkedHMM predict
2117Phosphoserine(CAMK2)HMM predict
2117Phosphoserine(CK1)HMM predict
2117Phosphoserine(ATM)HMM predict
2117Phosphoserine(IKK)HMM predict
2127Phosphoserine(ATM)HMM predict
2127Phosphoserine(IKK)HMM predict
2131Phosphotyrosine(Abl)HMM predict
2131Phosphotyrosine(Jak)HMM predict
2131Phosphotyrosine(Syk)HMM predict
2132O-linkedHMM predict
2132Phosphoserine(ATM)HMM predict
2137Phosphothreonine(MAPK)HMM predict
2146Phosphoserine(CK1)HMM predict
2146Phosphoserine(ATM)HMM predict
2159Phosphotyrosine(Abl)HMM predict
2160Phosphoserine(ATM)HMM predict
2165O-linkedHMM predict
2165Phosphothreonine(MAPK)HMM predict
2169O-linkedHMM predict
2170Phosphothreonine(PKC)HMM predict
2174Phosphotyrosine(Abl)HMM predict
2180Phosphothreonine(MAPK)HMM predict
2192Phosphothreonine(CDC2)HMM predict
2203Phosphotyrosine(Syk)HMM predict
2215O-linkedHMM predict
2218Phosphotyrosine(Abl)HMM predict
2218Phosphotyrosine(Jak)HMM predict
2219O-linkedHMM predict
2219Phosphoserine(ATM)HMM predict
2224O-linkedHMM predict
2224Phosphothreonine(MAPK)HMM predict
2275Phosphothreonine(CDC2)HMM predict
2275Phosphothreonine(MAPK)HMM predict
2275Phosphothreonine(CDK)HMM predict
2288O-linkedHMM predict
2305Phosphothreonine(CDC2)HMM predict
2305Phosphothreonine(MAPK)HMM predict
2305Phosphothreonine(CDK)HMM predict
2308Phosphoserine(ATM)HMM predict
2308Phosphoserine(IKK)HMM predict
2312Phosphoserine(IKK)HMM predict
2316Phosphoserine(ATM)HMM predict
2333Phosphoserine(IKK)HMM predict
2344Phosphoserine(ATM)HMM predict
2353Phosphoserine(ATM)HMM predict
2362O-linkedHMM predict
2362Phosphoserine(IKK)HMM predict
2365O-linkedHMM predict
2408Phosphoserine(ATM)HMM predict
2481MethylarginineHMM predict
2488O-linkedHMM predict
2494Phosphoserine(ATM)HMM predict
2511Phosphoserine(CDK)HMM predict
2519Phosphoserine(PKA)HMM predict
2519Phosphoserine(CAMK2)HMM predict
2527N-linkedHMM predict
2528N-linkedHMM predict
2532N-linkedHMM predict
2533N-linkedHMM predict
2631Phosphoserine(ATM)HMM predict
2638Phosphoserine(ATM)HMM predict
2638Phosphoserine(IKK)HMM predict
2664O-linkedHMM predict
2664O-linkedHMM predict
2665Phosphoserine(IKK)HMM predict
2668O-linkedHMM predict
2672Phosphoserine(CK1)HMM predict
2695Phosphoserine(CK1)HMM predict
2759SulfotyrosineHMM predict
2801N-linkedHMM predict
2811Phosphoserine(CDC2)HMM predict
2811Phosphoserine(CDK)HMM predict
2816Phosphoserine(IKK)HMM predict
2817O-linkedHMM predict
2854Phosphoserine(ATM)HMM predict
2915Phosphothreonine(CDK)HMM predict
2935O-linkedHMM predict
2937O-linkedHMM predict
2937Phosphoserine(CDC2)HMM predict
2937Phosphoserine(ATM)HMM predict
2942O-linkedHMM predict
2946Phosphoserine(CDC2)HMM predict
2972N-linkedHMM predict
3018O-linkedHMM predict
3022O-linkedHMM predict
3023O-linkedHMM predict
3024Phosphoserine(IKK)HMM predict
3026Phosphoserine(CK1)HMM predict
3026Phosphoserine(IKK)HMM predict
3154Phosphoserine(IKK)HMM predict
3173N-linkedHMM predict
3283O-linkedHMM predict
3298O-linkedHMM predict
3300O-linkedHMM predict
3325Phosphoserine(CDC2)HMM predict
3364O-linkedHMM predict
3364Phosphothreonine(CDC2)HMM predict
3371O-linkedHMM predict
3371Phosphoserine(IKK)HMM predict
3377Phosphoserine(ATM)HMM predict
3444O-linkedHMM predict
3444O-linkedHMM predict
3447Phosphoserine(CK1)HMM predict
3472Phosphoserine(CDK)HMM predict
3492Phosphoserine(IKK)HMM predict
3519Phosphoserine(CDC2)HMM predict
3519Phosphoserine(IKK)HMM predict
3528N-linkedHMM predict
3530O-linkedHMM predict
3538N-linkedHMM predict
3547Phosphoserine(CDC2)HMM predict
3565N-linkedHMM predict
3607Phosphothreonine(PKC)HMM predict
3624O-linkedHMM predict
3624Phosphothreonine(MAPK)HMM predict
3624Phosphothreonine(CDK)HMM predict
3627O-linkedHMM predict
3630O-linkedHMM predict
3630O-linkedHMM predict
3634Phosphothreonine(MAPK)HMM predict
3638O-linkedHMM predict
3640O-linkedHMM predict
3641O-linkedHMM predict
3642O-linkedHMM predict
3642O-linkedHMM predict
3642Phosphoserine(IKK)HMM predict
3643PhosphothreonineHMM predict
3647O-linkedHMM predict
3647O-linkedHMM predict
3648Phosphothreonine(MAPK)HMM predict
3648Phosphothreonine(CDK)HMM predict
3650O-linkedHMM predict
3668Phosphothreonine(MAPK)HMM predict
3690Phosphoserine(ATM)HMM predict
3725Phosphothreonine(PKC)HMM predict
3727Phosphoserine(IKK)HMM predict
3740N-linkedHMM predict
3754O-linkedHMM predict
3755O-linkedHMM predict
3758Phosphoserine(ATM)HMM predict
3758Phosphoserine(IKK)HMM predict
3758PhosphoserineHMM predict
3758Phosphoserine(MAPK)HMM predict
3762O-linkedHMM predict
3762O-linkedHMM predict
3769O-linkedHMM predict
3788Phosphoserine(CK1)HMM predict
3846Phosphothreonine(PKC)HMM predict
3854Phosphothreonine(PKA)HMM predict
3893N-linkedHMM predict
3896N-linkedHMM predict
3899Phosphothreonine(MAPK)HMM predict
3899PhosphothreonineHMM predict
3903O-linkedHMM predict
3907O-linkedHMM predict
3907Phosphothreonine(CDC2)HMM predict
3907Phosphothreonine(MAPK)HMM predict
3974O-linkedHMM predict
3977Phosphothreonine(MAPK)HMM predict
3977Phosphothreonine(CDK)HMM predict
3997Phosphothreonine(MAPK)HMM predict
4005Phosphoserine(IKK)HMM predict
4006Phosphoserine(CDC2)HMM predict
4009Phosphoserine(IKK)HMM predict
4034O-linkedHMM predict
4034Phosphoserine(CDC2)HMM predict
4066Phosphoserine(CDC2)HMM predict
4071Phosphoserine(CDC2)HMM predict
4227Phosphoserine(CK1)HMM predict
4263Phosphoserine(CK1)HMM predict
4267Phosphoserine(CDC2)HMM predict
4272Phosphothreonine(CDK)HMM predict
4274O-linkedHMM predict
4300Phosphoserine(CDC2)HMM predict
4300Phosphoserine(IKK)HMM predict
4304Phosphoserine(CDC2)HMM predict
4440Phosphotyrosine(Syk)HMM predict
4465S-palmitoylHMM predict
4474S-palmitoylHMM predict
4571Phosphoserine(MAPK)HMM predict
4686N-linkedHMM predict
4704N-linkedHMM predict
4730N-linkedHMM predict
4732O-linkedHMM predict
4737O-linkedHMM predict
4737Phosphoserine(IKK)HMM predict
4762Phosphotyrosine(INSR)HMM predict
4774Phosphotyrosine(Syk)HMM predict
4817Phosphotyrosine(INSR)HMM predict
4819Phosphoserine(ATM)HMM predict
4848N-linkedHMM predict
4854N-linkedHMM predict
4902GlycineHMM predict
4908LysineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_170606
  • Location:chr7 151462944-151764022
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 151764318 151764828 510 551
KLF4 hESGSE17917 151763945 151764127 182 14
Oct4 hESGSE17917 151763945 151764402 457 151
PHF8 293TGSE20725 151764255 151765182 927 696
TAF HelaGSE8489 151764754 151765899 1145 1304
TAF k562GSE8489 151764944 151766103 1159 1501
hScc1 BcellGSE12603 151764318 151764828 510 551
hScc1 G2GSE9613 151764318 151765018 700 646
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 151664864 151665100 236 0
CTCF CD4SISSRdata 151664864 151665100 236 0
CTCF G2GSE9613 151664776 151664990 214 0
CTCF G2GSE9613 151763629 151764010 381 0
H3K4me2 HCT116GSE10453 151762216 151762870 654 0
H3K4me3 colorectalcancer 151762216 151762906 690 0
H3ac HepG2E 151762180 151763008 828 0
Myc K562GSE19551 151669437 151669807 370 0
NFkBII GM12878GSE19485 151644237 151646302 2065 0
Nanog hESGSE18292 151727424 151727950 526 0
Pol2 GM12878GSE19551 151763819 151764167 348 0
PolII HeLaGSE12783 151762280 151765406 3126 0
TAF HelaGSE8489 151730160 151730341 181 0
TAF HelaGSE8489 151761927 151762757 830 0
TAF k562GSE8489 151761897 151763073 1176 0
hScc1 BcellGSE12603 151762402 151762721 319 0
hScc1 BcellGSE12603 151763196 151763763 567 0
hScc1 G2GSE9613 151762472 151764010 1538 0
Validated miRNA targets Top
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
24878 mRNA chr7 151275451 151280460 312 mRNA MLL3 chr7 151271503 151570699Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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