AutismKB 2.0

Annotation Detail for RAC1


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Basic Information Top
Gene Symbol:RAC1 ( MGC111543,TC-25,p21-Rac1 )
Gene Full Name: ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
Band: 7p22.1
Quick LinksEntrez ID:5879; OMIM: 602048; Uniprot ID:RAC1_HUMAN; ENSEMBL ID: ENSG00000136238; HGNC ID: 9801
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
32O-AMP-tyrosine; by Haemophilus IbpA.
35O-AMP-threonine; by Vibrio VopS.
39ADP-ribosylasparagine; by botulinum toxin
40Effector region (Potential).
71Phosphoserine.
189Cysteine methyl ester.
Location(AA) Modifications Resource
39ADP-ribosylasparagine (by botulinumtoxin) (By similarity).Swiss-Prot 53.0
71Phosphoserine (PKB
189Cysteine methyl ester.Swiss-Prot 53.0
189S-geranylgeranyl cysteine.Swiss-Prot 53.0
Location(AA) Modification Resource
32Phosphotyrosine(Jak)HMM predict
64Phosphotyrosine(Syk)HMM predict
86Phosphoserine(MAPK)HMM predict
181ProlineHMM predict
186LysineHMM predict
189S-farnesylHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_006908
  • Location:chr7 6380650-6410121
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Myc K562GSE19551 6374018 6374392 374 6446
PHF8 Hs68minusFBSGSE20725 6380133 6380645 512 262
STAT1 HeLaGSE12783 6373623 6374809 1186 6435
STAT1 IFNSISSRdata 6373661 6374709 1048 6466
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 6380545 6381289 744 0
CTCF G2GSE9613 6402196 6402460 264 0
ETS1 JurkatGSE17954 6380236 6381291 1055 0
FoxA1 MCF7MACSdata 6398744 6399163 419 0
H3K4me3 colorectalcancer 6381916 6382307 391 0
H3ac HepG2E 6381689 6382307 618 0
Myc K562GSE19551 6399113 6399944 831 0
Oct1 HelaGSE14283 6388130 6388173 43 0
P300 T30-glioblastomaGSE21026 6391164 6392501 1337 0
PHF8 HeLaGSE20725 6380036 6381542 1506 0
PHF8 Hs68plusFBSGSE20725 6380204 6381288 1084 0
TAF HelaGSE8489 6381748 6382307 559 0
TAF k562GSE8489 6381689 6382307 618 0
hScc1 G2GSE9613 6380412 6381152 740 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-122 hsa-mir-122 18 19935707
hsa-miR-122* hsa-mir-122 18 19935707
hsa-miR-124 hsa-mir-124-1 8 18619591
hsa-miR-124 hsa-mir-124-2 8 18619591
hsa-miR-124 hsa-mir-124-3 20 18619591
hsa-miR-132 hsa-mir-132 17 19850129
hsa-miR-132* hsa-mir-132 17 19850129
hsa-miR-150 hsa-mir-150 19 19892940
hsa-miR-150* hsa-mir-150 19 19892940
hsa-miR-151-3p hsa-mir-151 8 20812359
hsa-miR-151-3p hsa-mir-151 8 20305651
hsa-miR-151-5p hsa-mir-151 8 20812359
hsa-miR-151-5p hsa-mir-151 8 20305651
hsa-miR-182 hsa-mir-182 7 20490652
hsa-miR-182* hsa-mir-182 7 20490652
hsa-miR-194 hsa-mir-194-1 1 19892940
hsa-miR-194 hsa-mir-194-2 11 19892940
hsa-miR-30c hsa-mir-30c-2 6 20490652
hsa-miR-30c hsa-mir-30c-1 1 20490652
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018