AutismKB 2.0

Annotation Detail for RAF1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:RAF1 ( CRAF,NS5,Raf-1,c-Raf )
Gene Full Name: v-raf-1 murine leukemia viral oncogene homolog 1
Band: 3p25.2
Quick LinksEntrez ID:5894; OMIM: 164760; Uniprot ID:RAF1_HUMAN; ENSEMBL ID: ENSG00000132155; HGNC ID: 9829
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
43Phosphoserine.
244Phosphoserine.
252Phosphoserine.
257Phosphoserine.
258Phosphothreonine.
259Phosphoserine; by PKC.
268Phosphothreonine; by autocatalysis.
269Phosphothreonine; by PKA.
289Phosphoserine.
294Phosphoserine.
301Phosphoserine.
338Phosphoserine; by PAK2 and PAK3.
499Phosphoserine; by PKC.
612Phosphoserine.
621Phosphoserine.
642Phosphoserine.
Location(AA) Modifications Resource
29PhosphoserinePhospho.ELM 6.0
43Phosphoserine.Swiss-Prot 53.0
43Phosphoserine (PKA
233PhosphoserinePhospho.ELM 6.0
259Phosphoserine (AMPK
259Phosphoserine (by PKC).Swiss-Prot 53.0
268Phosphothreonine (by autocatalysis).Swiss-Prot 53.0
269Phosphothreonine (KSR1)Phospho.ELM 6.0
289PhosphoserinePhospho.ELM 6.0
294PhosphoserinePhospho.ELM 6.0
294Phosphoserine.Swiss-Prot 53.0
296PhosphoserinePhospho.ELM 6.0
301Phosphoserine.Swiss-Prot 53.0
301PhosphoserinePhospho.ELM 6.0
338Phosphoserine (PAK1;PAK3;PA)Phospho.ELM 6.0
338Phosphoserine (by PAK2 and PAK3).Swiss-Prot 53.0
339Phosphoserine (PAK1)Phospho.ELM 6.0
340PhosphotyrosinePhospho.ELM 6.0
341Phosphotyrosine (Src)Phospho.ELM 6.0
471PhosphoserinePhospho.ELM 6.0
491PhosphothreoninePhospho.ELM 6.0
494PhosphoserinePhospho.ELM 6.0
499Phosphoserine (by PKC).Swiss-Prot 53.0
499Phosphoserine (PKC
621Phosphoserine.Swiss-Prot 53.0
621Phosphoserine (AMPK
Location(AA) Modification Resource
29Phosphoserine(CDC2)HMM predict
43Phosphoserine(CK2)HMM predict
43Phosphoserine(CAMK2)HMM predict
43Phosphoserine(PKA)HMM predict
95S-palmitoylHMM predict
96S-palmitoylHMM predict
152S-palmitoylHMM predict
168S-palmitoylHMM predict
198N-linkedHMM predict
220Phosphoserine(PKA)HMM predict
220Phosphoserine(PKG)HMM predict
227Phosphoserine(CDK)HMM predict
232Phosphotyrosine(Abl)HMM predict
241N-linkedHMM predict
242O-linkedHMM predict
244Phosphoserine(CDK)HMM predict
244Phosphoserine(CDC2)HMM predict
246Phosphoserine(CK1)HMM predict
247O-linkedHMM predict
250Phosphoserine(CK1)HMM predict
252Phosphoserine(ATM)HMM predict
257Phosphoserine(IKK)HMM predict
257Phosphoserine(PKG)HMM predict
259Phosphoserine(CK1)HMM predict
259PhosphoserineHMM predict
259Phosphoserine(PKB)HMM predict
285Phosphoserine(IKK)HMM predict
285Phosphoserine(CAMK2)HMM predict
289Phosphoserine(IKK)HMM predict
289Phosphoserine(CDC2)HMM predict
289PhosphoserineHMM predict
289Phosphoserine(CDK)HMM predict
289Phosphoserine(MAPK)HMM predict
291Phosphoserine(IKK)HMM predict
291O-linkedHMM predict
294Phosphoserine(CK2)HMM predict
299N-linkedHMM predict
306Phosphoserine(IKK)HMM predict
310Phosphothreonine(CDC2)HMM predict
310Phosphothreonine(MAPK)HMM predict
341Phosphotyrosine(Syk)HMM predict
383Phosphothreonine(MAPK)HMM predict
458Phosphotyrosine(Jak)HMM predict
491Phosphothreonine(PKC)HMM predict
497Phosphoserine(IKK)HMM predict
565Phosphotyrosine(INSR)HMM predict
565Phosphotyrosine(Abl)HMM predict
567Phosphoserine(CDK)HMM predict
617N-linkedHMM predict
621PhosphoserineHMM predict
624Phosphoserine(CK1)HMM predict
642Phosphoserine(CDK)HMM predict
642Phosphoserine(CDC2)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_002880
  • Location:chr3 12600107-12680677
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 12680739 12681186 447 285
CTCF G2GSE9613 12687279 12687622 343 6773
CTCF G2GSE9613 12698271 12698417 146 17667
Fos K562GSE19551 12698982 12699456 474 18542
H3ac HepG2E 12681003 12681210 207 429
P300 T30-glioblastomaGSE21026 12695732 12696394 662 15386
PHF8 HeLaGSE20725 12679873 12681485 1612 2
PHF8 Hs68minusFBSGSE20725 12680013 12681552 1539 105
RARA MCF7GSE15244 12680902 12681210 308 379
RARG MCF7GSE15244 12680864 12681210 346 360
TFAP2C MCF7GSE21234 12695962 12696342 380 15475
p130 QuiescentGSE19898 12680905 12681103 198 327
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP JurkatGSE17954 12623136 12624562 1426 0
CTCF G2GSE9613 12679473 12679689 216 0
CTCF G2GSE9613 12680202 12680504 302 0
ETS1 JurkatGSE17954 12679484 12681284 1800 0
FOXA1 MCF7GSE15244 12654763 12654982 219 0
FOXA1 MCF7GSE15244 12664131 12664413 282 0
H3K4me2 HCT116GSE10453 12678926 12679905 979 0
H3K4me3 colorectalcancer 12678926 12680279 1353 0
H3ac HepG2E 12678926 12680017 1091 0
NRSF JurkatSISSRdata 12620548 12620748 200 0
NRSF-mono JurkatQuESTdata 12620559 12620882 323 0
Nanog hESGSE18292 12653985 12654154 169 0
Oct1 H2O2-HelaGSE14283 12604221 12604261 40 0
Oct1 H2O2-HelaGSE14283 12607642 12607679 37 0
Oct1 H2O2-HelaGSE14283 12655520 12655547 27 0
Oct1 HelaGSE14283 12607642 12607681 39 0
PHF8 293TGSE20725 12679761 12681177 1416 0
PHF8 Hs68plusFBSGSE20725 12678982 12681347 2365 0
RARA MCF7GSE15244 12637819 12637993 174 0
RARA MCF7GSE15244 12678926 12679943 1017 0
RUNX JurkatGSE17954 12623960 12624057 97 0
TAF k562GSE8489 12678926 12680055 1129 0
USF2 HepG2E 12664131 12664392 261 0
hScc1 BcellGSE12603 12678959 12681210 2251 0
hScc1 CdLSGSE12603 12664131 12664448 317 0
hScc1 CdLSGSE12603 12680121 12680712 591 0
hScc1 G2GSE9613 12679511 12680864 1353 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-212 hsa-mir-212 17 20613834
hsa-miR-7 hsa-mir-7-1 9 19073608
hsa-miR-7 hsa-mir-7-2 15 19073608
hsa-miR-7 hsa-mir-7-3 19 19073608
No data
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
17775 mRNA MKRN2 chr3 12573593 12600208 101 mRNA RAF1 chr3 12600107 12680678Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved