AutismKB 2.0

Annotation Detail for RARA


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Basic Information Top
Gene Symbol:RARA ( NR1B1,RAR )
Gene Full Name: retinoic acid receptor, alpha
Band: 17q21.2
Quick LinksEntrez ID:5914; OMIM: 180240; Uniprot ID:RARA_HUMAN; ENSEMBL ID: ENSG00000131759; HGNC ID: 9864
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
77Phosphoserine; by CDK7 (By similarity).
96Phosphoserine; by PKB/AKT1.
219Phosphoserine; by PKA.
369Phosphoserine; by PKA.
Location(AA) Modifications Resource
77Phosphoserine (by CDK7) (By similarity).Swiss-Prot 53.0
77Phosphoserine (CDK7)Phospho.ELM 6.0
181PhosphothreoninePhospho.ELM 6.0
445PhosphoserinePhospho.ELM 6.0
449Phosphoserine (By similarity).Swiss-Prot 53.0
456Phosphoserine (By similarity).Swiss-Prot 53.0
461Phosphoserine (By similarity).Swiss-Prot 53.0
461PhosphoserinePhospho.ELM 6.0
Location(AA) Modification Resource
7Phosphoserine(IKK)HMM predict
54O-linkedHMM predict
54O-linkedHMM predict
55Phosphothreonine(MAPK)HMM predict
55O-linkedHMM predict
57O-linkedHMM predict
57Phosphoserine(CDC2)HMM predict
60O-linkedHMM predict
63O-linkedHMM predict
67Phosphoserine(CK2)HMM predict
68O-linkedHMM predict
68Phosphoserine(CK1)HMM predict
74Phosphoserine(CDC2)HMM predict
74Phosphoserine(CDK)HMM predict
74O-linkedHMM predict
77O-linkedHMM predict
77Phosphoserine(IKK)HMM predict
96Phosphoserine(CK1)HMM predict
211N-linkedHMM predict
212N-linkedHMM predict
253O-linkedHMM predict
278Phosphothreonine(PKA)HMM predict
278Phosphothreonine(CDK)HMM predict
293N-linkedHMM predict
299N-linkedHMM predict
369PhosphoserineHMM predict
369Phosphoserine(PKA)HMM predict
369Phosphoserine(PKG)HMM predict
444S-farnesylHMM predict
444CysteineHMM predict
449Phosphoserine(ATM)HMM predict
449Phosphoserine(CDK)HMM predict
449Phosphoserine(CDC2)HMM predict
453N-linkedHMM predict
456O-linkedHMM predict
456Phosphoserine(CDC2)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_000964
  • Location:chr17 35718971-35767419
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
TFAP2C MCF7GSE21234 35716850 35717462 612 1816
hScc1 BcellGSE12603 35718810 35719118 308 8
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
ER MCF7GSE19013 35720727 35721834 1107 0
ER MCF7GSE19013 35724169 35724850 681 0
H3ac HepG2E 35719816 35720627 811 0
NFkBII GM12878GSE19485 35720086 35722008 1922 0
RARA MCF7GSE15244 35715991 35723869 7878 0
RARA MCF7GSE15244 35725291 35727776 2485 0
Rb SenescentGSE19898 35726394 35726873 479 0
TFAP2C MCF7GSE21234 35718854 35719572 718 0
TFAP2C MCF7GSE21234 35720774 35722498 1724 0
TFAP2C MCF7GSE21234 35723784 35724878 1094 0
TFAP2C MCF7GSE21234 35726091 35726801 710 0
USF2 HepG2E 35726945 35728057 1112 0
hScc1 CdLSGSE12603 35727089 35728137 1048 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-107 hsa-mir-107 10 20348243
hsa-miR-125a-3p hsa-mir-125a 19 16331254
hsa-miR-125a-5p hsa-mir-125a 19 16331254
hsa-miR-195 hsa-mir-195 17 16331254
hsa-miR-195* hsa-mir-195 17 16331254
hsa-miR-200a hsa-mir-200a 1 16331254
hsa-miR-200a* hsa-mir-200a 1 16331254
hsa-miR-224 hsa-mir-224 X 16331254
hsa-miR-424 hsa-mir-424 X 20348243
hsa-miR-424* hsa-mir-424 X 20348243
hsa-miR-570 hsa-mir-570 3 20348243
hsa-miR-618 hsa-mir-618 12 20348243
hsa-miR-760 hsa-mir-760 1 20348243
No data
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
11086 mRNA RARA chr17 35740895 35767420 291 mRNA chr17 35757826 35760317Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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