Annotation Detail for RDX

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Basic Information Top

Gene Symbol:	RDX ( DFNB24 )
Gene Full Name:	radixin
Band:	11q23
Quick Links	Entrez ID:5962; OMIM: 179410; Uniprot ID:RADI_HUMAN; ENSEMBL ID: ENSG00000137710; HGNC ID: 9944
Relate to Another Database:	SFARIGene; denovo-db

General

Expression

Regulation

Pathways, Diseases and Drugs

PTM

TF binding site

miRNA targets

Cis-NATs

Post Translation Modification

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PTM Sites from Uniprot:5 results
Experimental PTM Sites from dbPTM:2 results
Predicted PTM Sites by profile HMM from dbPTM:9 results

Location(AA)	Modification
79	N6-acetyllysine.
258	N6-acetyllysine.
263	N6-acetyllysine.
270	Phosphotyrosine (By similarity).
344	N6-acetyllysine.

Location(AA)	Modifications	Resource
564	Phosphothreonine (ROCK
573	Phosphothreonine (ROCK

Location(AA)	Modification	Resource
11	Phosphothreonine(PKC)	HMM predict
23	N-linked	HMM predict
90	Phosphoserine(CK2)	HMM predict
116	Phosphotyrosine(INSR)	HMM predict
116	Phosphotyrosine(Syk)	HMM predict
201	Phosphotyrosine(INSR)	HMM predict
465	Phosphothreonine(PKC)	HMM predict
468	O-linked	HMM predict
564	Phosphothreonine(PKC)	HMM predict

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

RefSeq ID: NM_002906
Location:chr11 109605375-109672646
strand:-

Upstream the gene:16 results
Downstream the gene:2 results
Inside the gene:11 results

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
FOXA1	DLD1	GSE12801	109679199	109679577	378	6742
FOXA1	DLD1	GSE12801	109681353	109682147	794	9104
FOXA1	MCF7	GSE15244	109672729	109674017	1288	727
FOXA1	MCF7	GSE15244	109681459	109682147	688	9157
Fos	K562	GSE19551	109687653	109688179	526	15270
FoxA1	MCF7	MACSdata	109673453	109673753	300	957
FoxA1	MCF7	MACSdata	109679310	109679500	190	6759
FoxA1	MCF7	MACSdata	109681572	109681912	340	9096
LIN9	G0	GSE7516	109672729	109673426	697	431
Nanog	hES	GSE18292	109673625	109674329	704	1331
RARA	MCF7	GSE15244	109681353	109682147	794	9104
RARG	MCF7	GSE15244	109681685	109682147	462	9270
STAT1	HeLa	GSE12782	109674882	109676192	1310	2891
STAT1	HeLa	GSE12783	109674882	109676107	1225	2848
p130	Senescent	GSE19898	109672723	109673233	510	332
p130	shRbSenescent	GSE19898	109672713	109673098	385	259

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
FOXA1	DLD1	GSE12801	109591354	109592151	797	13623
Oct1	Hela	GSE14283	109585548	109585585	37	19809

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length
ER	E2-MCF7	GSE14664	109665573	109665605	32
H3ac	HepG2	E	109670327	109671754	1427
Myc	hES	GSE17917	109671659	109671935	276
Oct1	H2O2-Hela	GSE14283	109617872	109617934	62
Oct1	H2O2-Hela	GSE14283	109628148	109628176	28
Oct1	Hela	GSE14283	109612355	109612404	49
Oct1	Hela	GSE14283	109617874	109617906	32
Oct1	Hela	GSE14283	109633014	109633048	34
RNAII	Tamoxifen-MCF7	GSE14664	109617872	109617928	56
hScc1	CdLS	GSE12603	109671505	109673175	1670
hScc1	G2	GSE9613	109671989	109672911	922

Validated miRNA targets

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miR Walk:56 results
Tarbase V5.0:0 results

Micro RNA Name	Stem Loop Name	The chromosome that miRNA located	Publication
hsa-let-7a	hsa-let-7a-1	9	19270793
hsa-let-7a	hsa-let-7a-2	11	19270793
hsa-let-7a	hsa-let-7a-3	22	19270793
hsa-let-7a*	hsa-let-7a-1	9	19270793
hsa-let-7a*	hsa-let-7a-3	22	19270793
hsa-let-7b	hsa-let-7b	22	19270793
hsa-let-7b*	hsa-let-7b	22	19270793
hsa-let-7c	hsa-let-7c	21	19270793
hsa-let-7c*	hsa-let-7c	21	19270793
hsa-let-7d	hsa-let-7d	9	19270793
hsa-let-7d*	hsa-let-7d	9	19270793
hsa-let-7e	hsa-let-7e	19	19270793
hsa-let-7e*	hsa-let-7e	19	19270793
hsa-let-7f	hsa-let-7f-1	9	19270793
hsa-let-7f	hsa-let-7f-2	X	19270793
hsa-let-7f-1*	hsa-let-7f-1	9	19270793
hsa-let-7f-2*	hsa-let-7f-2	X	19270793
hsa-let-7g	hsa-let-7g	3	19270793
hsa-let-7g*	hsa-let-7g	3	19270793
hsa-let-7i	hsa-let-7i	12	19270793
hsa-let-7i*	hsa-let-7i	12	19270793
hsa-miR-10b	hsa-mir-10b	2	19270793
hsa-miR-10b*	hsa-mir-10b	2	19270793
hsa-miR-15a	hsa-mir-15a	13	19270793
hsa-miR-15a*	hsa-mir-15a	13	19270793
hsa-miR-15b	hsa-mir-15b	3	19270793
hsa-miR-15b*	hsa-mir-15b	3	19270793
hsa-miR-16	hsa-mir-16-1	13	19270793
hsa-miR-16	hsa-mir-16-2	3	19270793
hsa-miR-17	hsa-mir-17	13	19270793
hsa-miR-17*	hsa-mir-17	13	19270793
hsa-miR-181a	hsa-mir-181a-2	9	19270793
hsa-miR-181a	hsa-mir-181a-1	1	19270793
hsa-miR-181a*	hsa-mir-181a-1	1	19270793
hsa-miR-181a-2*	hsa-mir-181a-2	9	19270793
hsa-miR-181b	hsa-mir-181b-1	1	19270793
hsa-miR-181b	hsa-mir-181b-2	9	19270793
hsa-miR-181c	hsa-mir-181c	19	19270793
hsa-miR-181c*	hsa-mir-181c	19	19270793
hsa-miR-181d	hsa-mir-181d	19	19270793
hsa-miR-182	hsa-mir-182	7	20186779
hsa-miR-182*	hsa-mir-182	7	20186779
hsa-miR-183	hsa-mir-183	7	20739942
hsa-miR-183	hsa-mir-183	7	20186779
hsa-miR-183*	hsa-mir-183	7	20739942
hsa-miR-183*	hsa-mir-183	7	20186779
hsa-miR-26a	hsa-mir-26a-1	3	19270793
hsa-miR-26a	hsa-mir-26a-2	12	19270793
hsa-miR-26a-1*	hsa-mir-26a-1	3	19270793
hsa-miR-26a-2*	hsa-mir-26a-2	12	19270793
hsa-miR-26b	hsa-mir-26b	2	19270793
hsa-miR-26b*	hsa-mir-26b	2	19270793
hsa-miR-31	hsa-mir-31	9	20530680
hsa-miR-31*	hsa-mir-31	9	20530680
hsa-miR-92a	hsa-mir-92a-1	13	19270793
hsa-miR-92a	hsa-mir-92a-2	X	19270793

Cis-Nats regulation

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Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

Studies: 1,036
Genes: 1,379
CNVs/SVs: 5,420
SNVs/Indels: 11,669
de novo Mutations: 5,669
Mosaics: 789
Linkage Regions: 172

Paper Collected: 6/30/2018

Last Update: 8/26/2018

AutismKB 2.0

Annotation Detail for RDX

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics