AutismKB 2.0

Annotation Detail for REST


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Basic Information Top
Gene Symbol:REST ( NRSF,XBR )
Gene Full Name: RE1-silencing transcription factor
Band: 4q12
Quick LinksEntrez ID:5978; OMIM: 600571; Uniprot ID:REST_HUMAN; ENSEMBL ID: ENSG00000084093; HGNC ID: 9966
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
864Phosphoserine.
Location(AA) Modifications Resource
864Phosphoserine.Swiss-Prot 53.0
864PhosphoserinePhospho.ELM 6.0
Location(AA) Modification Resource
59N-linkedHMM predict
83N-linkedHMM predict
85Phosphoserine(CK2)HMM predict
85Phosphoserine(CK1)HMM predict
87PhosphoserineHMM predict
87Phosphoserine(CK2)HMM predict
128Phosphoserine(CK2)HMM predict
144Phosphothreonine(MAPK)HMM predict
154Phosphoserine(PKG)HMM predict
166Phosphotyrosine(Syk)HMM predict
201Phosphoserine(PKG)HMM predict
201Phosphoserine(CK2)HMM predict
201Phosphoserine(IKK)HMM predict
203Phosphoserine(CK2)HMM predict
248Phosphotyrosine(EGFR)HMM predict
291Phosphotyrosine(EGFR)HMM predict
313Phosphoserine(CDK)HMM predict
314Phosphoserine(CDK)HMM predict
314Phosphoserine(ATM)HMM predict
327Phosphoserine(IKK)HMM predict
368Phosphotyrosine(Syk)HMM predict
417N-linkedHMM predict
440N-linkedHMM predict
443N-linkedHMM predict
465Phosphoserine(CK2)HMM predict
495Phosphoserine(PKG)HMM predict
529Phosphoserine(CK1)HMM predict
541Phosphothreonine(PKC)HMM predict
553N-linkedHMM predict
554N-linkedHMM predict
583Phosphothreonine(PKC)HMM predict
586N-linkedHMM predict
593Phosphoserine(PKA)HMM predict
734Phosphoserine(ATM)HMM predict
766Phosphoserine(ATM)HMM predict
782Phosphoserine(ATM)HMM predict
857Phosphothreonine(CK2)HMM predict
861Phosphoserine(IKK)HMM predict
861Phosphoserine(ATM)HMM predict
864Phosphoserine(IKK)HMM predict
914N-linkedHMM predict
928Phosphothreonine(MAPK)HMM predict
958N-linkedHMM predict
963N-linkedHMM predict
971O-linkedHMM predict
992O-linkedHMM predict
996O-linkedHMM predict
1000N-linkedHMM predict
1002Phosphoserine(ATM)HMM predict
1024Phosphoserine(CK1)HMM predict
1065S-palmitoylHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_005612
  • Location:chr4 57468798-57493095
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 57465464 57465610 146 3262
Nanog hESGSE18292 57468118 57468832 714 324
Oct1 H2O2-HelaGSE14283 57451034 57451066 32 17749
Oct1 HelaGSE14283 57455813 57455845 32 12970
Sox2 hESGSE18292 57468344 57468787 443 233
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Oct1 HelaGSE14283 57495119 57495165 46 2047
P300 T30-glioblastomaGSE21026 57498242 57498727 485 5389
Rb SenescentGSE19898 57498167 57498410 243 5193
p130 SenescentGSE19898 57498173 57498454 281 5218
p63 keratinocytesGSE17611 57497930 57498773 843 5256
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 57468712 57470375 1663 0
CTCF G2GSE9613 57471943 57472161 218 0
CTCF G2GSE9613 57491759 57492053 294 0
Gata2 K562GSE18868 57468811 57469701 890 0
H3K4me3 colorectalcancer 57469833 57470829 996 0
H3ac HepG2E 57470142 57471241 1099 0
NRSF JurkatGSE13047 57468840 57470569 1729 0
NRSF-mono JurkatQuESTdata 57468636 57470504 1868 0
Oct4 hESGSE21916 57467917 57469837 1920 0
TAF HelaGSE8489 57469994 57471905 1911 0
hScc1 BcellGSE12603 57468865 57469710 845 0
hScc1 BcellGSE12603 57470072 57470375 303 0
hScc1 G2GSE9613 57468649 57470287 1638 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-124 hsa-mir-124-1 8 19561591
hsa-miR-124 hsa-mir-124-2 8 19561591
hsa-miR-124 hsa-mir-124-3 20 19561591
hsa-miR-124 hsa-mir-124-1 8 19458943
hsa-miR-124 hsa-mir-124-2 8 19458943
hsa-miR-124 hsa-mir-124-3 20 19458943
hsa-miR-124 hsa-mir-124-1 8 17403776
hsa-miR-124 hsa-mir-124-2 8 17403776
hsa-miR-124 hsa-mir-124-3 20 17403776
hsa-miR-128 hsa-mir-128-1 2 17403776
hsa-miR-128 hsa-mir-128-2 3 17403776
hsa-miR-132 hsa-mir-132 17 19458943
hsa-miR-132 hsa-mir-132 17 17002790
hsa-miR-132* hsa-mir-132 17 19458943
hsa-miR-132* hsa-mir-132 17 17002790
hsa-miR-143 hsa-mir-143 5 19137007
hsa-miR-143* hsa-mir-143 5 19137007
hsa-miR-191 hsa-mir-191 3 20559549
hsa-miR-191* hsa-mir-191 3 20559549
hsa-miR-21 hsa-mir-21 17 19242418
hsa-miR-21 hsa-mir-21 17 19150961
hsa-miR-21 hsa-mir-21 17 18362916
hsa-miR-21* hsa-mir-21 17 19242418
hsa-miR-21* hsa-mir-21 17 19150961
hsa-miR-21* hsa-mir-21 17 18362916
hsa-miR-222 hsa-mir-222 X 20559549
hsa-miR-222* hsa-mir-222 X 20559549
hsa-miR-320a hsa-mir-320a 8 19118166
hsa-miR-320b hsa-mir-320b-1 1 19118166
hsa-miR-320b hsa-mir-320b-2 1 19118166
hsa-miR-320c hsa-mir-320c-1 18 19118166
hsa-miR-320c hsa-mir-320c-2 18 19118166
hsa-miR-320d hsa-mir-320d-1 13 19118166
hsa-miR-320d hsa-mir-320d-2 X 19118166
hsa-miR-9 hsa-mir-9-2 5 20624818
hsa-miR-9 hsa-mir-9-1 1 20624818
hsa-miR-9 hsa-mir-9-3 15 20624818
hsa-miR-9 hsa-mir-9-1 1 19458943
hsa-miR-9 hsa-mir-9-2 5 19458943
hsa-miR-9 hsa-mir-9-3 15 19458943
hsa-miR-9 hsa-mir-9-1 1 19137007
hsa-miR-9 hsa-mir-9-2 5 19137007
hsa-miR-9 hsa-mir-9-3 15 19137007
hsa-miR-9 hsa-mir-9-1 1 19118166
hsa-miR-9 hsa-mir-9-2 5 19118166
hsa-miR-9 hsa-mir-9-3 15 19118166
hsa-miR-9 hsa-mir-9-1 1 17002790
hsa-miR-9 hsa-mir-9-2 5 17002790
hsa-miR-9 hsa-mir-9-3 15 17002790
hsa-miR-9* hsa-mir-9-2 5 20624818
hsa-miR-9* hsa-mir-9-1 1 19561591
hsa-miR-9* hsa-mir-9-2 5 19561591
hsa-miR-9* hsa-mir-9-3 15 19561591
hsa-miR-9* hsa-mir-9-1 1 19118166
hsa-miR-9* hsa-mir-9-2 5 19118166
hsa-miR-9* hsa-mir-9-3 15 19118166
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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