AutismKB 2.0

Annotation Detail for RET


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Basic Information Top
Gene Symbol:RET ( CDHF12,CDHR16,HSCR1,MEN2A,MEN2B,MTC1,PTC,RET-ELE1,RET51 )
Gene Full Name: ret proto-oncogene
Band: 10q11.21
Quick LinksEntrez ID:5979; OMIM: 164761; Uniprot ID:RET_HUMAN; ENSEMBL ID: ENSG00000165731; HGNC ID: 9967
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
98N-linked (GlcNAc...) (Potential).
151N-linked (GlcNAc...) (Potential).
199N-linked (GlcNAc...) (Potential).
336N-linked (GlcNAc...) (Potential).
343N-linked (GlcNAc...) (Potential).
361N-linked (GlcNAc...) (Potential).
367N-linked (GlcNAc...) (Potential).
377N-linked (GlcNAc...) (Potential).
394N-linked (GlcNAc...) (Potential).
448N-linked (GlcNAc...) (Potential).
468N-linked (GlcNAc...) (Potential).
554N-linked (GlcNAc...) (Potential).
696Phosphoserine.
806Phosphotyrosine; by autocatalysis.
809Phosphotyrosine; by autocatalysis.
900Phosphotyrosine; by autocatalysis.
905Phosphotyrosine; by autocatalysis.
981Phosphotyrosine; by autocatalysis.
1015Phosphotyrosine; by autocatalysis.
1062Phosphotyrosine; by autocatalysis.
1090Phosphotyrosine; by autocatalysis.
1096Phosphotyrosine; by autocatalysis.
Location(AA) Modifications Resource
98N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
151N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
199N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
336N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
343N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
361N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
367N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
377N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
394N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
448N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
468N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
554N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
687Phosphotyrosine (Ret)Phospho.ELM 6.0
696PhosphoserinePhospho.ELM 6.0
791PhosphotyrosinePhospho.ELM 6.0
806Phosphotyrosine (Ret)Phospho.ELM 6.0
806Phosphotyrosine (by autocatalysis).Swiss-Prot 53.0
809Phosphotyrosine (Ret)Phospho.ELM 6.0
809Phosphotyrosine (by autocatalysis).Swiss-Prot 53.0
826Phosphotyrosine (Ret)Phospho.ELM 6.0
891PhosphoserinePhospho.ELM 6.0
900Phosphotyrosine (Ret)Phospho.ELM 6.0
900Phosphotyrosine (by autocatalysis).Swiss-Prot 53.0
905Phosphotyrosine (Ret)Phospho.ELM 6.0
905Phosphotyrosine (by autocatalysis).Swiss-Prot 53.0
981Phosphotyrosine (Ret)Phospho.ELM 6.0
981Phosphotyrosine (by autocatalysis).Swiss-Prot 53.0
1015Phosphotyrosine (by autocatalysis).Swiss-Prot 53.0
1015Phosphotyrosine (Ret)Phospho.ELM 6.0
1029Phosphotyrosine (Ret)Phospho.ELM 6.0
1062Phosphotyrosine (by autocatalysis).Swiss-Prot 53.0
1062Phosphotyrosine (Ret)Phospho.ELM 6.0
1090Phosphotyrosine (Ret)Phospho.ELM 6.0
1090Phosphotyrosine (by autocatalysis).Swiss-Prot 53.0
1096Phosphotyrosine (by autocatalysis).Swiss-Prot 53.0
1096Phosphotyrosine (Ret)Phospho.ELM 6.0
Location(AA) Modification Resource
128Phosphoserine(CDC2)HMM predict
151N-linkedHMM predict
152O-linkedHMM predict
173Phosphoserine(PKA)HMM predict
280O-linkedHMM predict
315Phosphothreonine(PKA)HMM predict
336N-linkedHMM predict
377N-linkedHMM predict
448N-linkedHMM predict
456O-linkedHMM predict
468N-linkedHMM predict
508Phosphotyrosine(EGFR)HMM predict
536Phosphoserine(CDC2)HMM predict
554N-linkedHMM predict
556O-linkedHMM predict
656S-palmitoylHMM predict
696Phosphoserine(IKK)HMM predict
696Phosphoserine(PKA)HMM predict
696Phosphoserine(PKB)HMM predict
763N-linkedHMM predict
834N-linkedHMM predict
835PhosphoserineHMM predict
836Phosphoserine(CK1)HMM predict
847Phosphothreonine(PKC)HMM predict
900Phosphotyrosine(Syk)HMM predict
900PhosphotyrosineHMM predict
905Phosphotyrosine(Jak)HMM predict
905Phosphotyrosine(Jak)HMM predict
905Phosphotyrosine(EGFR)HMM predict
981PhosphotyrosineHMM predict
1022Phosphothreonine(MAPK)HMM predict
1029SulfotyrosineHMM predict
1034Phosphoserine(CK2)HMM predict
1034Phosphoserine(CK1)HMM predict
1092N-linkedHMM predict
1096PhosphotyrosineHMM predict
1098N-linkedHMM predict
1102Phosphoserine(CDC2)HMM predict
1109MethionineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_020630
  • Location:chr10 42892532-42942959
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
ER MCF7GSE19013 42875885 42876253 368 16464
ER MCF7GSE19013 42884123 42884613 490 8165
Oct1 H2O2-HelaGSE14283 42872718 42872744 26 19802
Oct1 HelaGSE14283 42872717 42872746 29 19801
Oct1 HelaGSE14283 42884981 42885027 46 7529
Oct1 HelaGSE14283 42885636 42885720 84 6855
TFAP2C MCF7GSE21234 42884314 42884877 563 7937
hScc1 BcellGSE12603 42873774 42874103 329 18594
hScc1 BcellGSE12603 42888799 42889383 584 3442
hScc1 BcellGSE12603 42890001 42890400 399 2332
hScc1 BcellGSE12603 42890992 42891342 350 1366
hScc1 BcellGSE12603 42891615 42892779 1164 336
hScc1 CdLSGSE12603 42892115 42892851 736 50
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 42920923 42921281 358 0
CTCF CD4SISSRdata 42920923 42921281 358 0
CTCF HelaGSE12889 42894424 42894824 400 0
CTCF JurkatGSE12889 42894455 42894645 190 0
ER MCF7GSE19013 42897414 42898047 633 0
ER MCF7GSE19013 42925758 42926985 1227 0
FoxA1 MCF7MACSdata 42897562 42897929 367 0
NRSF JurkatGSE13047 42908896 42909360 464 0
Oct1 H2O2-HelaGSE14283 42901312 42901345 33 0
Oct1 H2O2-HelaGSE14283 42903606 42903632 26 0
Oct1 HelaGSE14283 42901315 42901346 31 0
Oct1 HelaGSE14283 42929497 42929532 35 0
RARG MCF7GSE15244 42902928 42903318 390 0
RUNX JurkatGSE17954 42921080 42921182 102 0
Stat6 IL-4-hr4GSE17850 42893862 42894336 474 0
TAF k562GSE8489 42902780 42903247 467 0
TFAP2C MCF7GSE21234 42897391 42898449 1058 0
TFAP2C MCF7GSE21234 42926117 42926858 741 0
hScc1 BcellGSE12603 42894114 42894676 562 0
hScc1 BcellGSE12603 42901391 42901785 394 0
hScc1 BcellGSE12603 42917736 42918193 457 0
hScc1 BcellGSE12603 42920384 42921538 1154 0
hScc1 BcellGSE12603 42921777 42922770 993 0
hScc1 BcellGSE12603 42934571 42935411 840 0
hScc1 CdLSGSE12603 42894195 42894707 512 0
hScc1 CdLSGSE12603 42920991 42921503 512 0
p130 QuiescentGSE19898 42920081 42920262 181 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-let-7a hsa-let-7a-1 9 19956384
hsa-let-7a hsa-let-7a-2 11 19956384
hsa-let-7a hsa-let-7a-3 22 19956384
hsa-let-7a* hsa-let-7a-1 9 19956384
hsa-let-7a* hsa-let-7a-3 22 19956384
hsa-let-7b hsa-let-7b 22 19956384
hsa-let-7b* hsa-let-7b 22 19956384
hsa-let-7c hsa-let-7c 21 19956384
hsa-let-7c* hsa-let-7c 21 19956384
hsa-let-7d hsa-let-7d 9 19956384
hsa-let-7d* hsa-let-7d 9 19956384
hsa-let-7e hsa-let-7e 19 19956384
hsa-let-7e* hsa-let-7e 19 19956384
hsa-let-7f hsa-let-7f-1 9 19956384
hsa-let-7f hsa-let-7f-2 X 19956384
hsa-let-7f-1* hsa-let-7f-1 9 19956384
hsa-let-7f-2* hsa-let-7f-2 X 19956384
hsa-let-7g hsa-let-7g 3 19956384
hsa-let-7g* hsa-let-7g 3 19956384
hsa-let-7i hsa-let-7i 12 19956384
hsa-let-7i* hsa-let-7i 12 19956384
hsa-miR-1 hsa-mir-1-2 18 21311168
hsa-miR-1 hsa-mir-1-1 20 21311168
hsa-miR-146a hsa-mir-146a 5 16365291
hsa-miR-146a* hsa-mir-146a 5 16365291
hsa-miR-146b-3p hsa-mir-146b 10 20459574
hsa-miR-146b-5p hsa-mir-146b 10 20459574
hsa-miR-21 hsa-mir-21 17 16365291
hsa-miR-21* hsa-mir-21 17 16365291
hsa-miR-221 hsa-mir-221 X 16365291
hsa-miR-221* hsa-mir-221 X 16365291
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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