Annotation Detail for RHEB

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Basic Information Top

Gene Symbol:	RHEB ( MGC111559,RHEB2 )
Gene Full Name:	Ras homolog enriched in brain
Band:	7q36.1
Quick Links	Entrez ID:6009; OMIM: 601293; Uniprot ID:RHEB_HUMAN; ENSEMBL ID: ENSG00000106615; HGNC ID: 10011
Relate to Another Database:	SFARIGene; denovo-db

Post Translation Modification

Location(AA)	Modification
43	Effector region (By similarity).
181	Cysteine methyl ester (Probable).

Location(AA)	Modifications	Resource
181	Cysteine methyl ester (Probable).	Swiss-Prot 53.0
181	S-farnesyl cysteine.	Swiss-Prot 53.0

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CTCF	G2	GSE9613	150847130	150848942	1812	94
Fos	K562	GSE19551	150847807	150848457	650	190
PHF8	HeLa	GSE20725	150848078	150849058	980	626
Rb	Growing	GSE19898	150848001	150848287	286	202
p130	Quiescent	GSE19898	150847934	150848471	537	260
p130	Senescent	GSE19898	150847837	150848545	708	249
p130	shRbSenescent	GSE19898	150847898	150848464	566	239

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CBP	T30-glioblastoma	GSE21026	150787468	150788962	1494	5817
CTCF	G2	GSE9613	150787722	150788261	539	6040
CTCF	G2	GSE9613	150789607	150790098	491	4179
P300	T30-glioblastoma	GSE21026	150787175	150789912	2737	5488
RARA	MCF7	GSE15244	150787722	150788846	1124	5748
Sox2	hES	GSE18292	150786529	150786713	184	7411
TFAP2C	MCF7	GSE21234	150781141	150781653	512	12635

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length
FOXA1	MCF7	GSE15244	150831970	150832309	339
FOXA1	MCF7	GSE15244	150845951	150846929	978
H3K4me2	HCT116	GSE10453	150845527	150846679	1152
H3K4me3	colorectal	cancer	150845456	150846021	565
H3K4me3	colorectal	cancer	150846370	150846929	559
H3ac	HepG2	E	150845416	150846864	1448
NFkBII	GM12878	GSE19485	150798535	150802309	3774
Oct4	hES	GSE21916	150799555	150800458	903
P300	T30-glioblastoma	GSE21026	150819795	150820468	673
PHF8	HeLa	GSE20725	150846987	150847739	752
RUNX	Jurkat	GSE17954	150808722	150808824	102
Rb	Senescent	GSE19898	150819942	150820214	272
Rb	shRbQuiescent	GSE19898	150800294	150800551	257
TAF	Hela	GSE8489	150845416	150846835	1419
hScc1	Bcell	GSE12603	150846021	150846679	658
hScc1	Bcell	GSE12603	150846965	150847756	791
hScc1	CdLS	GSE12603	150799756	150800672	916
hScc1	CdLS	GSE12603	150846195	150846679	484
hScc1	G2	GSE9613	150846093	150849016	2923
p130	shRbSenescent	GSE19898	150846229	150846430	201

Validated miRNA targets

Micro RNA Name	Stem Loop Name	The chromosome that miRNA located	Publication
hsa-let-7b	hsa-let-7b	22	18668040
hsa-let-7b*	hsa-let-7b	22	18668040
hsa-miR-1	hsa-mir-1-2	18	18827171
hsa-miR-1	hsa-mir-1-1	20	18827171
hsa-miR-1	hsa-mir-1-2	18	17234972
hsa-miR-1	hsa-mir-1-1	20	17234972
hsa-miR-1	hsa-mir-1-2	18	18668040
hsa-miR-1	hsa-mir-1-1	20	18668040
hsa-miR-133a	hsa-mir-133a-1	18	18827171
hsa-miR-133a	hsa-mir-133a-2	20	18827171
hsa-miR-155	hsa-mir-155	21	18668040
hsa-miR-155*	hsa-mir-155	21	18668040
hsa-miR-16	hsa-mir-16-1	13	18668040
hsa-miR-16	hsa-mir-16-2	3	18668040
hsa-miR-206	hsa-mir-206	6	18827171
hsa-miR-30a	hsa-mir-30a	6	18668040
hsa-miR-30a*	hsa-mir-30a	6	18668040
hsa-miR-30b	hsa-mir-30b	8	18668040
hsa-miR-30b*	hsa-mir-30b	8	18668040
hsa-miR-30c	hsa-mir-30c-2	6	18668040
hsa-miR-30c	hsa-mir-30c-1	1	18668040
hsa-miR-30c-1*	hsa-mir-30c-1	1	18668040
hsa-miR-30c-2*	hsa-mir-30c-2	6	18668040
hsa-miR-30d	hsa-mir-30d	8	18668040
hsa-miR-30d*	hsa-mir-30d	8	18668040
hsa-miR-30e	hsa-mir-30e	1	18668040
hsa-miR-30e*	hsa-mir-30e	1	18668040

ID in Tarbase	Data Type	Support Type	miRNA	Gene	Direct Support	Publication
1001	Unknown	pSILAC	miR-155	RHEB	down 50-25%	18668040
Ensembl	Protein Type	Differentially expressed in	Pathology or Event	Mis Regulation	Gene Expression	Tumour Involvement
ENSG00000106615		n_a	n_a	n_a	"epithelium, squamous cell, lymphocyte, muscle cell"	"benign tumour, malignant tumour, carcinoma, leukaemia, non-Hodgkin's, sarcoma"

Cis-Nats regulation

Simple Query:

Paper Collected: 6/30/2018

Last Update: 8/26/2018