AutismKB 2.0

Annotation Detail for BRD2


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Basic Information Top
Gene Symbol:BRD2 ( D6S113E,DKFZp686N0336,FLJ31942,FSH,FSRG1,KIAA9001,NAT,RING3,RNF3 )
Gene Full Name: bromodomain containing 2
Band: 6p21.32
Quick LinksEntrez ID:6046; OMIM: 601540; Uniprot ID:BRD2_HUMAN; ENSEMBL ID: ENSG00000204256; HGNC ID: 1103
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
1N-acetylmethionine.
37Phosphoserine.
298Phosphoserine.
301Phosphoserine.
305Phosphoserine.
320Phosphoserine.
559Nuclear localization signal (Potential).
633Phosphoserine.
724Phosphothreonine.
Location(AA) Modifications Resource
298Phosphoserine.Swiss-Prot 53.0
298PhosphoserinePhospho.ELM 6.0
301Phosphoserine.Swiss-Prot 53.0
301PhosphoserinePhospho.ELM 6.0
724Phosphothreonine.Swiss-Prot 53.0
Location(AA) Modification Resource
6Phosphothreonine(CDC2)HMM predict
9N-linkedHMM predict
45Phosphoserine(CDK)HMM predict
47O-linkedHMM predict
67O-linkedHMM predict
113Phosphotyrosine(INSR)HMM predict
219O-linkedHMM predict
224O-linkedHMM predict
228Phosphothreonine(CDK)HMM predict
228Phosphothreonine(MAPK)HMM predict
228O-linkedHMM predict
248Phosphoserine(CDC2)HMM predict
285O-linkedHMM predict
289Phosphothreonine(MAPK)HMM predict
289O-linkedHMM predict
291O-linkedHMM predict
298O-linkedHMM predict
298Phosphoserine(IKK)HMM predict
298Phosphoserine(CDC2)HMM predict
301Phosphoserine(ATM)HMM predict
301Phosphoserine(CDC2)HMM predict
301Phosphoserine(IKK)HMM predict
301O-linkedHMM predict
301Phosphoserine(MAPK)HMM predict
334Phosphoserine(ATM)HMM predict
362Phosphoserine(CK1)HMM predict
386Phosphotyrosine(INSR)HMM predict
408Phosphotyrosine(Syk)HMM predict
408SulfotyrosineHMM predict
466O-linkedHMM predict
466O-linkedHMM predict
478Phosphoserine(CK1)HMM predict
480Phosphoserine(CK2)HMM predict
481Phosphoserine(CK1)HMM predict
486Phosphoserine(CK1)HMM predict
487Phosphoserine(CK1)HMM predict
487Phosphoserine(IKK)HMM predict
489Phosphoserine(CK2)HMM predict
490Phosphoserine(CK2)HMM predict
490Phosphoserine(CK1)HMM predict
491Phosphoserine(CK2)HMM predict
491Phosphoserine(CK1)HMM predict
507Phosphoserine(CK2)HMM predict
507Phosphoserine(CK1)HMM predict
509Phosphoserine(CK2)HMM predict
510Phosphoserine(CK1)HMM predict
510Phosphoserine(ATM)HMM predict
512Phosphoserine(CK1)HMM predict
538Phosphoserine(ATM)HMM predict
593O-linkedHMM predict
608O-linkedHMM predict
620Phosphothreonine(PKA)HMM predict
631Phosphotyrosine(INSR)HMM predict
633Phosphoserine(CK2)HMM predict
633Phosphoserine(CK2)HMM predict
675PhosphoserineHMM predict
675Phosphoserine(PKB)HMM predict
679Phosphoserine(CK2)HMM predict
748N-linkedHMM predict
763Phosphoserine(CK2)HMM predict
763Phosphoserine(CK1)HMM predict
778Phosphoserine(CK2)HMM predict
793Phosphoserine(ATM)HMM predict
793Phosphoserine(CK1)HMM predict
795O-linkedHMM predict
796Phosphoserine(CK1)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_005104
  • Location:chr6 33044414-33057058
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 33042959 33044581 1622 645
H3K4me2 HCT116GSE10453 33042483 33043930 1447 1208
H3K4me3 colorectalcancer 33042994 33043715 721 1060
H3ac HepG2E 33042670 33044063 1393 1048
Oct1 HelaGSE14283 33038002 33038029 27 6399
Oct1 HelaGSE14283 33039181 33039251 70 5199
RARA MCF7GSE15244 33042483 33044027 1544 1160
Rb SenescentGSE19898 33044053 33044671 618 53
Rb shRbSenescenceGSE19898 33044036 33044395 359 199
TAF HelaGSE8489 33042483 33042846 363 1750
TAF HelaGSE8489 33043105 33043656 551 1034
TAF k562GSE8489 33042483 33043715 1232 1316
hScc1 CdLSGSE12603 33043312 33043752 440 883
p130 QuiescentGSE19898 33043990 33044254 264 293
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 33060512 33060960 448 3678
CTCF CD4SISSRdata 33060512 33060960 448 3678
CTCF G2GSE9613 33060316 33060945 629 3572
ER E2-MCF7GSE14664 33066213 33066251 38 9174
Oct1 HelaGSE14283 33065968 33066040 72 8946
hScc1 BcellGSE12603 33060278 33060945 667 3553
hScc1 CdLSGSE12603 33060278 33061325 1047 3743
hScc1 G2GSE9613 33060278 33060945 667 3553
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 33046231 33047224 993 0
CTCF G2GSE9613 33047672 33048894 1222 0
H3K4me2 HCT116GSE10453 33048811 33049699 888 0
H3K4me3 colorectalcancer 33048259 33049585 1326 0
H3K4me3 colorectalcancer 33049996 33050740 744 0
H3ac HepG2E 33044998 33046490 1492 0
H3ac HepG2E 33046813 33047488 675 0
H3ac HepG2E 33048100 33049836 1736 0
H3ac HepG2E 33050142 33051614 1472 0
PHF8 293TGSE20725 33043681 33046625 2944 0
Pol2 GM12878GSE19551 33043360 33049238 5878 0
RARA MCF7GSE15244 33046909 33047375 466 0
Rb GrowingGSE19898 33047694 33048004 310 0
Rb QuiescentGSE19898 33045294 33045568 274 0
Rb QuiescentGSE19898 33047212 33047681 469 0
Rb QuiescentGSE19898 33047718 33048289 571 0
Rb SenescentGSE19898 33047244 33048162 918 0
TAF HelaGSE8489 33046881 33047417 536 0
TAF HelaGSE8489 33048448 33050630 2182 0
TAF k562GSE8489 33045236 33046038 802 0
TAF k562GSE8489 33046843 33051910 5067 0
TFAP2C MCF7GSE21234 33044647 33045264 617 0
USF1 HepG2E 33042883 33046231 3348 0
USF1 HepG2E 33046909 33047343 434 0
USF2 HepG2E 33042994 33046405 3411 0
USF2 HepG2E 33046881 33047375 494 0
USF2 HepG2E 33048971 33049585 614 0
hScc1 BcellGSE12603 33047082 33047452 370 0
p130 QuiescentGSE19898 33044356 33044586 230 0
p130 QuiescentGSE19898 33044682 33044823 141 0
p130 QuiescentGSE19898 33044881 33046538 1657 0
p130 QuiescentGSE19898 33046582 33048174 1592 0
p130 SenescentGSE19898 33043936 33046596 2660 0
p130 SenescentGSE19898 33046765 33048446 1681 0
p130 shRbQuiescentGSE19898 33044881 33047697 2816 0
p130 shRbSenescentGSE19898 33043865 33046755 2890 0
p130 shRbSenescentGSE19898 33046762 33048771 2009 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-23b hsa-mir-23b 9 21325043
hsa-miR-23b* hsa-mir-23b 9 21325043
hsa-miR-29a hsa-mir-29a 7 20734245
hsa-miR-29a* hsa-mir-29a 7 20734245
hsa-miR-30d hsa-mir-30d 8 20734245
hsa-miR-30d* hsa-mir-30d 8 20734245
No data
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
22450 mRNA BRD2 chr6 33044414 33057059 55 EST chr6 33025411 33044849Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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