AutismKB 2.0

Annotation Detail for ROBO1


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Basic Information Top
Gene Symbol:ROBO1 ( DUTT1,FLJ21882,MGC131599,MGC133277,SAX3 )
Gene Full Name: roundabout, axon guidance receptor, homolog 1 (Drosophila)
Band: 3p12.3
Quick LinksEntrez ID:6091; OMIM: 602430; Uniprot ID:ROBO1_HUMAN; ENSEMBL ID: ENSG00000169855; HGNC ID: 10249
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
160N-linked (GlcNAc...) (Potential).
463N-linked (GlcNAc...) (Potential).
790N-linked (GlcNAc...) (Potential).
820N-linked (GlcNAc...) (Potential).
827N-linked (GlcNAc...) (Potential).
940Phosphoserine.
1038Phosphotyrosine; by ABL; in vitro.
1055Phosphoserine.
1073Phosphotyrosine; by ABL; in vitro.
1114Phosphotyrosine; by ABL; in vitro.
1240Phosphothreonine.
Location(AA) Modifications Resource
160N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
463N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
790N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
820N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
827N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
940Phosphoserine.Swiss-Prot 53.0
940PhosphoserinePhospho.ELM 6.0
1038Phosphotyrosine; by ABL; in vitro.Swiss-Prot 53.0
1073Phosphotyrosine; by ABL; in vitro.Swiss-Prot 53.0
1114Phosphotyrosine; by ABL; in vitro.Swiss-Prot 53.0
1240Phosphothreonine.Swiss-Prot 53.0
1240PhosphothreoninePhospho.ELM 6.0
Location(AA) Modification Resource
18Phosphoserine(CDK)HMM predict
18Phosphoserine(ATM)HMM predict
42Phosphothreonine(CDC2)HMM predict
96Phosphothreonine(MAPK)HMM predict
263Phosphoserine(PKA)HMM predict
292Phosphothreonine(PKC)HMM predict
401Phosphoserine(CDK)HMM predict
406Phosphoserine(CK1)HMM predict
406Phosphoserine(CAMK2)HMM predict
406Phosphoserine(PKA)HMM predict
408Phosphoserine(ATM)HMM predict
463N-linkedHMM predict
479O-linkedHMM predict
481Phosphoserine(CDC2)HMM predict
523Phosphotyrosine(INSR)HMM predict
531Phosphoserine(IKK)HMM predict
555O-linkedHMM predict
555Phosphothreonine(PKA)HMM predict
565Phosphoserine(CK1)HMM predict
609Phosphothreonine(PKC)HMM predict
661Phosphoserine(ATM)HMM predict
682N-linkedHMM predict
690Phosphoserine(CK1)HMM predict
776O-linkedHMM predict
790N-linkedHMM predict
820N-linkedHMM predict
827N-linkedHMM predict
879PhosphoserineHMM predict
885Phosphoserine(IKK)HMM predict
946O-linkedHMM predict
946O-linkedHMM predict
1005N-linkedHMM predict
1009Phosphotyrosine(INSR)HMM predict
1038Phosphotyrosine(SRC)HMM predict
1038Phosphotyrosine(Abl)HMM predict
1038Phosphotyrosine(Syk)HMM predict
1065N-linkedHMM predict
1067O-linkedHMM predict
1071Phosphothreonine(MAPK)HMM predict
1071O-linkedHMM predict
1073Phosphotyrosine(Abl)HMM predict
1089N-linkedHMM predict
1094PhosphoserineHMM predict
1129N-linkedHMM predict
1139N-linkedHMM predict
1145N-linkedHMM predict
1151N-linkedHMM predict
1157Phosphoserine(CK1)HMM predict
1158Phosphoserine(PKB)HMM predict
1158O-linkedHMM predict
1162Phosphoserine(ATM)HMM predict
1205Phosphoserine(ATM)HMM predict
1205Phosphoserine(CK2)HMM predict
1210SulfotyrosineHMM predict
1248O-linkedHMM predict
1256O-linkedHMM predict
1259O-linkedHMM predict
1260O-linkedHMM predict
1262O-linkedHMM predict
1264Phosphothreonine(MAPK)HMM predict
1264Phosphothreonine(CDK)HMM predict
1266Phosphoserine(CDC2)HMM predict
1266Phosphoserine(ATM)HMM predict
1297Phosphoserine(CDC2)HMM predict
1297O-linkedHMM predict
1297Phosphoserine(IKK)HMM predict
1297Phosphoserine(ATM)HMM predict
1306Phosphoserine(CDC2)HMM predict
1306O-linkedHMM predict
1311Phosphotyrosine(SRC)HMM predict
1311Phosphotyrosine(Abl)HMM predict
1354Phosphothreonine(MAPK)HMM predict
1365Phosphoserine(CK1)HMM predict
1384Phosphoserine(CK1)HMM predict
1389Phosphoserine(IKK)HMM predict
1392Phosphoserine(CK1)HMM predict
1393Phosphoserine(ATM)HMM predict
1441Phosphothreonine(PKA)HMM predict
1442Phosphoserine(CDC2)HMM predict
1442Phosphoserine(IKK)HMM predict
1442O-linkedHMM predict
1442Phosphoserine(MAPK)HMM predict
1445Phosphoserine(IKK)HMM predict
1602Phosphoserine(IKK)HMM predict
1602Phosphoserine(CK2)HMM predict
1602Phosphoserine(CK1)HMM predict
1603Phosphoserine(IKK)HMM predict
1604O-linkedHMM predict
1608Phosphoserine(CK1)HMM predict
1612Phosphoserine(CK1)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_002941
  • Location:chr3 78729079-79721750
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
FoxA1 MCF7MACSdata 79735026 79735293 267 13409
Oct1 HelaGSE14283 79741054 79741114 60 19334
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF HelaGSE12889 79218322 79218512 190 0
CTCF G2GSE9613 79218313 79218591 278 0
CTCF G2GSE9613 79493764 79493978 214 0
CTCF G2GSE9613 79578979 79579124 145 0
CTCF G2GSE9613 79653128 79653493 365 0
ER E2-MCF7GSE14664 79493584 79493623 39 0
ER E2-MCF7GSE14664 79618084 79618131 47 0
ER Fulvestrant-MCF7GSE14664 79191592 79191626 34 0
ER Fulvestrant-MCF7GSE14664 79356397 79356430 33 0
ER Fulvestrant-MCF7GSE14664 79493578 79493627 49 0
FOXA1 MCF7GSE15244 79151324 79151706 382 0
FOXA1 MCF7GSE15244 79429124 79429508 384 0
FOXA1 MCF7GSE15244 79659592 79659888 296 0
FOXA1 MCF7GSE15244 79663532 79664083 551 0
H3ac HepG2E 79151237 79151635 398 0
Nanog hESGSE18292 79292665 79293173 508 0
Nanog hESGSE18292 79377288 79378038 750 0
Nanog hESGSE18292 79629264 79629654 390 0
Oct1 H2O2-HelaGSE14283 79225720 79225752 32 0
Oct1 H2O2-HelaGSE14283 79227199 79227232 33 0
Oct1 H2O2-HelaGSE14283 79240947 79240979 32 0
Oct1 H2O2-HelaGSE14283 79249708 79249735 27 0
Oct1 H2O2-HelaGSE14283 79356396 79356430 34 0
Oct1 H2O2-HelaGSE14283 79358065 79358093 28 0
Oct1 H2O2-HelaGSE14283 79451556 79451588 32 0
Oct1 H2O2-HelaGSE14283 79618773 79618804 31 0
Oct1 H2O2-HelaGSE14283 79630670 79630703 33 0
Oct1 HelaGSE14283 79170149 79170182 33 0
Oct1 HelaGSE14283 79191589 79191624 35 0
Oct1 HelaGSE14283 79221067 79221094 27 0
Oct1 HelaGSE14283 79240947 79240982 35 0
Oct1 HelaGSE14283 79331335 79331373 38 0
Oct1 HelaGSE14283 79356396 79356428 32 0
Oct1 HelaGSE14283 79399981 79400020 39 0
Oct1 HelaGSE14283 79451545 79451596 51 0
Oct1 HelaGSE14283 79451984 79452019 35 0
Oct1 HelaGSE14283 79458734 79458764 30 0
Oct1 HelaGSE14283 79479104 79479134 30 0
Oct1 HelaGSE14283 79493547 79493630 83 0
Oct1 HelaGSE14283 79502145 79502214 69 0
Oct1 HelaGSE14283 79547397 79547435 38 0
Oct1 HelaGSE14283 79561784 79561844 60 0
Oct1 HelaGSE14283 79581001 79581063 62 0
Oct1 HelaGSE14283 79597490 79597522 32 0
Oct1 HelaGSE14283 79609714 79609742 28 0
Oct1 HelaGSE14283 79618773 79618804 31 0
Oct1 HelaGSE14283 79664731 79664766 35 0
Oct1 HelaGSE14283 79686623 79686670 47 0
P300 T0-glioblastomaGSE21026 79428707 79429809 1102 0
P300 T30-glioblastomaGSE21026 79299590 79300606 1016 0
P300 T30-glioblastomaGSE21026 79428673 79429848 1175 0
PAX3-FKHR Rh4GSE19063 79428540 79429902 1362 0
RARA MCF7GSE15244 79663640 79664083 443 0
RARA MCF7GSE15244 79666187 79666924 737 0
RARA MCF7GSE15244 79671924 79672573 649 0
RNAII Tamoxifen-MCF7GSE14664 79502143 79502186 43 0
Rb GrowingGSE19898 79151268 79151666 398 0
Rb GrowingGSE19898 79428284 79428512 228 0
TFAP2C MCF7GSE21234 79707460 79707847 387 0
USF2 HepG2E 79151192 79152206 1014 0
hScc1 BcellGSE12603 79218313 79218591 278 0
hScc1 BcellGSE12603 79653091 79653493 402 0
hScc1 CdLSGSE12603 79653091 79653581 490 0
hScc1 G2GSE9613 79218238 79218631 393 0
hScc1 G2GSE9613 79493602 79494010 408 0
hScc1 G2GSE9613 79629342 79629774 432 0
hScc1 G2GSE9613 79653009 79653622 613 0
p130 QuiescentGSE19898 79379654 79379814 160 0
p63 keratinocytesGSE17611 79556349 79557336 987 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-217 hsa-mir-217 2 20300657
hsa-miR-218 hsa-mir-218-1 4 20947829
hsa-miR-218 hsa-mir-218-2 5 20947829
hsa-miR-218 hsa-mir-218-1 4 21385904
hsa-miR-218 hsa-mir-218-2 5 21385904
hsa-miR-218 hsa-mir-218-1 4 21385766
hsa-miR-218 hsa-mir-218-2 5 21385766
hsa-miR-218 hsa-mir-218-1 4 20300657
hsa-miR-218-1* hsa-mir-218-1 4 20300657
No data
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
18329 EST chr3 78729080 78729802 722 mRNA ROBO1 chr3 78729079 79151264Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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