AutismKB 2.0

Annotation Detail for ROBO2


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Basic Information Top
Gene Symbol:ROBO2 ( KIAA1568,SAX3 )
Gene Full Name: roundabout, axon guidance receptor, homolog 2 (Drosophila)
Band: 3p12.3
Quick LinksEntrez ID:6092; OMIM: 602431; Uniprot ID:ROBO2_HUMAN; ENSEMBL ID: ENSG00000185008; HGNC ID: 10250
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
123N-linked (GlcNAc...) (Potential).
426N-linked (GlcNAc...) (Potential).
752N-linked (GlcNAc...) (Potential).
782N-linked (GlcNAc...) (Potential).
789N-linked (GlcNAc...) (Potential).
845N-linked (GlcNAc...) (Potential).
Location(AA) Modifications Resource
123N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
426N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
752N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
782N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
789N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
845N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
Location(AA) Modification Resource
59Phosphothreonine(MAPK)HMM predict
108Phosphotyrosine(INSR)HMM predict
125Phosphoserine(PKG)HMM predict
138N-linkedHMM predict
255Phosphothreonine(PKC)HMM predict
283Phosphothreonine(PKA)HMM predict
291Phosphotyrosine(INSR)HMM predict
291Phosphotyrosine(SRC)HMM predict
309Phosphothreonine(PKC)HMM predict
371Phosphoserine(CDC2)HMM predict
389Phosphotyrosine(Jak)HMM predict
426N-linkedHMM predict
486Phosphotyrosine(INSR)HMM predict
487O-linkedHMM predict
491O-linkedHMM predict
497O-linkedHMM predict
498Phosphoserine(IKK)HMM predict
546Phosphothreonine(MAPK)HMM predict
561Phosphoserine(ATM)HMM predict
591Phosphotyrosine(Jak)HMM predict
591Phosphotyrosine(SRC)HMM predict
648Phosphothreonine(MAPK)HMM predict
693Phosphothreonine(PKC)HMM predict
728Phosphothreonine(PKC)HMM predict
737O-linkedHMM predict
744O-linkedHMM predict
750O-linkedHMM predict
752N-linkedHMM predict
782N-linkedHMM predict
789N-linkedHMM predict
845N-linkedHMM predict
846N-linkedHMM predict
847Phosphoserine(CK1)HMM predict
907N-linkedHMM predict
927O-linkedHMM predict
936N-linkedHMM predict
937N-linkedHMM predict
938Phosphoserine(IKK)HMM predict
939N-linkedHMM predict
974Phosphotyrosine(INSR)HMM predict
986N-linkedHMM predict
995O-linkedHMM predict
997Phosphotyrosine(Abl)HMM predict
1057N-linkedHMM predict
1058Phosphoserine(PKG)HMM predict
1065N-linkedHMM predict
1071N-linkedHMM predict
1090Phosphotyrosine(INSR)HMM predict
1099Phosphotyrosine(INSR)HMM predict
1099Phosphotyrosine(Syk)HMM predict
1099SulfotyrosineHMM predict
1103Phosphoserine(IKK)HMM predict
1131Phosphothreonine(CDK)HMM predict
1140Phosphoserine(CDC2)HMM predict
1150O-linkedHMM predict
1152O-linkedHMM predict
1154Phosphothreonine(CDK)HMM predict
1154Phosphothreonine(MAPK)HMM predict
1156Phosphoserine(CDC2)HMM predict
1240Phosphothreonine(MAPK)HMM predict
1266Phosphothreonine(PKA)HMM predict
1266Phosphothreonine(PKC)HMM predict
1266O-linkedHMM predict
1267Phosphoserine(CDC2)HMM predict
1267Phosphoserine(IKK)HMM predict
1271O-linkedHMM predict
1276O-linkedHMM predict
1280Phosphoserine(ATM)HMM predict
1282Phosphoserine(ATM)HMM predict
1288Phosphothreonine(PKC)HMM predict
1310Phosphothreonine(CK2)HMM predict
1325O-linkedHMM predict
1325Phosphoserine(CDK)HMM predict
1325Phosphoserine(CDC2)HMM predict
1330PhosphoserineHMM predict
1330Phosphoserine(IKK)HMM predict
1332O-linkedHMM predict
1334O-linkedHMM predict
1337O-linkedHMM predict
1337O-linkedHMM predict
1341Phosphothreonine(PKC)HMM predict
1370Phosphoserine(ATM)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_002942
  • Location:chr3 77171983-77779350
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 77170130 77170770 640 1534
CTCF G2GSE9613 77171686 77172167 481 57
H3K27me3 colorectalcancer 77170352 77171315 963 1150
hScc1 BcellGSE12603 77170171 77170915 744 1441
hScc1 BcellGSE12603 77171524 77172018 494 213
hScc1 G2GSE9613 77170058 77170878 820 1516
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
ER Fulvestrant-MCF7GSE14664 77799284 77799317 33 19950
Oct1 HelaGSE14283 77799273 77799319 46 19946
PAX3-FKHR Rh4GSE19063 77786675 77787867 1192 7921
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T0-glioblastomaGSE21026 77221643 77222227 584 0
CBP T30-glioblastomaGSE21026 77221748 77222442 694 0
CTCF G2GSE9613 77174759 77175145 386 0
CTCF G2GSE9613 77387110 77387369 259 0
H3K27me3 colorectalcancer 77172207 77173525 1318 0
Nanog ESGSE20650 77211671 77212485 814 0
Nanog ESGSE20650 77607180 77607873 693 0
Nanog ESGSE20650 77656223 77656799 576 0
Nanog hESGSE18292 77211754 77212488 734 0
Oct1 H2O2-HelaGSE14283 77265848 77265888 40 0
Oct1 H2O2-HelaGSE14283 77313441 77313483 42 0
Oct1 H2O2-HelaGSE14283 77448374 77448408 34 0
Oct1 H2O2-HelaGSE14283 77471925 77471954 29 0
Oct1 H2O2-HelaGSE14283 77701273 77701320 47 0
Oct1 HelaGSE14283 77265848 77265884 36 0
Oct1 HelaGSE14283 77313443 77313483 40 0
Oct1 HelaGSE14283 77448374 77448407 33 0
Oct1 HelaGSE14283 77545471 77545503 32 0
Oct1 HelaGSE14283 77581529 77581565 36 0
Oct1 HelaGSE14283 77701274 77701365 91 0
Oct1 HelaGSE14283 77727197 77727233 36 0
Rb GrowingGSE19898 77224083 77224293 210 0
Rb GrowingGSE19898 77558706 77558908 202 0
Rb shRbQuiescentGSE19898 77734806 77734989 183 0
hScc1 G2GSE9613 77386850 77387478 628 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-144 hsa-mir-144 17 21276775
hsa-miR-144* hsa-mir-144 17 21276775
hsa-miR-145 hsa-mir-145 5 21276775
hsa-miR-145* hsa-mir-145 5 21276775
hsa-miR-214 hsa-mir-214 1 21276775
hsa-miR-214* hsa-mir-214 1 21276775
hsa-miR-218 hsa-mir-218-1 4 20947829
hsa-miR-218 hsa-mir-218-2 5 20947829
hsa-miR-218 hsa-mir-218-1 4 21385766
hsa-miR-218 hsa-mir-218-2 5 21385766
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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