AutismKB 2.0

Annotation Detail for ROCK1


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Basic Information Top
Gene Symbol:ROCK1 ( MGC131603,MGC43611,P160ROCK,PRO0435 )
Gene Full Name: Rho-associated, coiled-coil containing protein kinase 1
Band: 18q11.1
Quick LinksEntrez ID:6093; OMIM: 601702; Uniprot ID:ROCK1_HUMAN; ENSEMBL ID: ENSG00000067900; HGNC ID: 10251
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
2N-acetylserine.
455Phosphothreonine.
456Phosphoserine.
647N6-acetyllysine.
1105Phosphoserine.
1180Phosphothreonine.
Location(AA) Modifications Resource
Location(AA) Modification Resource
23Phosphoserine(IKK)HMM predict
76Phosphotyrosine(Syk)HMM predict
76Phosphotyrosine(Jak)HMM predict
98Phosphothreonine(PKA)HMM predict
148Phosphotyrosine(Jak)HMM predict
150Phosphotyrosine(INSR)HMM predict
168Phosphotyrosine(Syk)HMM predict
240Phosphotyrosine(Jak)HMM predict
240Phosphotyrosine(EGFR)HMM predict
240Phosphotyrosine(INSR)HMM predict
414N-linkedHMM predict
417Phosphoserine(CK2)HMM predict
419N-linkedHMM predict
567Phosphoserine(PKG)HMM predict
572Phosphoserine(CK1)HMM predict
576Phosphoserine(ATM)HMM predict
576Phosphoserine(CK2)HMM predict
597PhosphoserineHMM predict
597Phosphoserine(ATM)HMM predict
599Phosphothreonine(PKC)HMM predict
603Phosphotyrosine(Jak)HMM predict
603PhosphotyrosineHMM predict
603SulfotyrosineHMM predict
604Phosphotyrosine(Jak)HMM predict
604Phosphotyrosine(Syk)HMM predict
633Phosphoserine(PKB)HMM predict
771N-linkedHMM predict
973SulfotyrosineHMM predict
1085Phosphoserine(CK2)HMM predict
1098Phosphoserine(ATM)HMM predict
1102Phosphoserine(IKK)HMM predict
1162Phosphoserine(IKK)HMM predict
1301Phosphoserine(ATM)HMM predict
1328Phosphoserine(CDK)HMM predict
1333Phosphoserine(IKK)HMM predict
1348N-linkedHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_005406
  • Location:chr18 16783702-16945809
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Oct1 HelaGSE14283 16958189 16958233 44 12402
PHF8 293TGSE20725 16945014 16946640 1626 18
p130 SenescentGSE19898 16945936 16946123 187 220
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 16945159 16945973 814 0
Fos K562GSE19551 16807433 16807689 256 0
H3K4me3 colorectalcancer 16942450 16943190 740 0
H3K4me3 colorectalcancer 16944252 16944928 676 0
H3ac HepG2E 16944349 16944965 616 0
NRSF mAbJurkat 16833132 16833430 298 0
NRSF-mono JurkatQuESTdata 16831417 16831694 277 0
NRSF-poly JurkatQuESTdata 16831414 16831744 330 0
Oct1 HelaGSE14283 16888836 16888864 28 0
PHF8 HeLaGSE20725 16944899 16946038 1139 0
TAF HelaGSE8489 16944211 16945054 843 0
TFAP2C MCF7GSE21234 16908341 16908761 420 0
hScc1 BcellGSE12603 16944893 16946153 1260 0
p130 SenescentGSE19898 16945384 16945834 450 0
p63 keratinocytesGSE17611 16890359 16891176 817 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-146a hsa-mir-146a 5 18174313
hsa-miR-146a* hsa-mir-146a 5 18174313
hsa-miR-494 hsa-mir-494 14 20837890
hsa-miR-584 hsa-mir-584 5 21119662
No data
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
11984 HTC chr18 16814281 16814874 593 mRNA ROCK1 chr18 16787532 16944869 Non-exonic Bidirectional (NOB) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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