AutismKB 2.0

Annotation Detail for ROS1


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Basic Information Top
Gene Symbol:ROS1 ( MCF3,ROS,c-ros-1 )
Gene Full Name: c-ros oncogene 1 , receptor tyrosine kinase
Band: 6q22.1
Quick LinksEntrez ID:6098; OMIM: 165020; Uniprot ID:ROS_HUMAN; ENSEMBL ID: ENSG00000047936; HGNC ID: 10261
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
52N-linked (GlcNAc...) (Potential).
114N-linked (GlcNAc...) (Potential).
123N-linked (GlcNAc...) (Potential).
324N-linked (GlcNAc...) (Potential).
352N-linked (GlcNAc...) (Potential).
396N-linked (GlcNAc...) (Potential).
471N-linked (GlcNAc...) (Potential).
607N-linked (GlcNAc...) (Potential).
628N-linked (GlcNAc...) (Potential).
706N-linked (GlcNAc...) (Potential).
714N-linked (GlcNAc...) (Potential).
732N-linked (GlcNAc...) (Potential).
939N-linked (GlcNAc...) (Potential).
961N-linked (GlcNAc...) (Potential).
1015N-linked (GlcNAc...) (Potential).
1087N-linked (GlcNAc...) (Potential).
1090N-linked (GlcNAc...) (Potential).
1095N-linked (GlcNAc...) (Potential).
1211N-linked (GlcNAc...) (Potential).
1272N-linked (GlcNAc...) (Potential).
1330N-linked (GlcNAc...) (Potential).
1458N-linked (GlcNAc...) (Potential).
1461N-linked (GlcNAc...) (Potential).
1474N-linked (GlcNAc...) (Potential).
1499N-linked (GlcNAc...) (Potential).
1565N-linked (GlcNAc...) (Potential).
1669N-linked (GlcNAc...) (Potential).
1715N-linked (GlcNAc...) (Potential).
1738N-linked (GlcNAc...) (Potential).
1808N-linked (GlcNAc...) (Potential).
2114Phosphotyrosine; by autocatalysis (By
Location(AA) Modifications Resource
52N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
114N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
123N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
324N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
352N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
396N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
471N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
607N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
628N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
706N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
714N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
732N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
939N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
961N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1015N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1087N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1090N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1095N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1211N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1272N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1330N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1458N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1461N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1474N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1499N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1565N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1669N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1715N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1738N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1808N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
2114Phosphotyrosine (by autocatalysis) (Bysimilarity).Swiss-Prot 53.0
2274PhosphotyrosinePhospho.ELM 6.0
2334PhosphotyrosinePhospho.ELM 6.0
Location(AA) Modification Resource
19S-palmitoylHMM predict
52N-linkedHMM predict
91Phosphotyrosine(SRC)HMM predict
91Phosphotyrosine(EGFR)HMM predict
116Phosphothreonine(PKC)HMM predict
123N-linkedHMM predict
147O-linkedHMM predict
164Phosphotyrosine(Jak)HMM predict
180Phosphoserine(IKK)HMM predict
183Phosphoserine(CDC2)HMM predict
188Phosphothreonine(CDK)HMM predict
205Phosphoserine(CK2)HMM predict
278O-linkedHMM predict
278Phosphoserine(CK1)HMM predict
278O-linkedHMM predict
278Phosphoserine(IKK)HMM predict
280O-linkedHMM predict
281O-linkedHMM predict
305Phosphoserine(PKG)HMM predict
324N-linkedHMM predict
352N-linkedHMM predict
396N-linkedHMM predict
399N-linkedHMM predict
407O-linkedHMM predict
471N-linkedHMM predict
552Phosphoserine(ATM)HMM predict
607N-linkedHMM predict
615Phosphoserine(PKG)HMM predict
615O-linkedHMM predict
653Phosphoserine(CDK)HMM predict
653Phosphoserine(CDC2)HMM predict
661Phosphoserine(IKK)HMM predict
664O-linkedHMM predict
706N-linkedHMM predict
714N-linkedHMM predict
715N-linkedHMM predict
732N-linkedHMM predict
829Phosphoserine(CDK)HMM predict
871O-linkedHMM predict
880Phosphothreonine(PKC)HMM predict
884Phosphoserine(ATM)HMM predict
916Phosphoserine(IKK)HMM predict
961N-linkedHMM predict
1015N-linkedHMM predict
1033O-linkedHMM predict
1042O-linkedHMM predict
1087N-linkedHMM predict
1090N-linkedHMM predict
1095N-linkedHMM predict
1105N-linkedHMM predict
1139Phosphotyrosine(Abl)HMM predict
1211N-linkedHMM predict
1245Phosphoserine(ATM)HMM predict
1272N-linkedHMM predict
1318O-linkedHMM predict
1330N-linkedHMM predict
1458N-linkedHMM predict
1461N-linkedHMM predict
1474N-linkedHMM predict
1482Phosphoserine(CDC2)HMM predict
1484O-linkedHMM predict
1487Phosphotyrosine(SRC)HMM predict
1499N-linkedHMM predict
1565N-linkedHMM predict
1658Phosphothreonine(CDC2)HMM predict
1663Phosphotyrosine(SRC)HMM predict
1707Phosphoserine(ATM)HMM predict
1712Phosphotyrosine(INSR)HMM predict
1715N-linkedHMM predict
1718N-linkedHMM predict
1738N-linkedHMM predict
1741Phosphoserine(CK1)HMM predict
1741Phosphoserine(IKK)HMM predict
1792Phosphothreonine(PKA)HMM predict
1793Phosphoserine(IKK)HMM predict
1808N-linkedHMM predict
1841Phosphotyrosine(INSR)HMM predict
1981Phosphothreonine(PKC)HMM predict
1987Phosphothreonine(CK2)HMM predict
2023Phosphotyrosine(Jak)HMM predict
2092Phosphotyrosine(INSR)HMM predict
2110Phosphotyrosine(Syk)HMM predict
2114Phosphotyrosine(Jak)HMM predict
2115Phosphotyrosine(Jak)HMM predict
2176Phosphothreonine(PKC)HMM predict
2234N-linkedHMM predict
2235N-linkedHMM predict
2240N-linkedHMM predict
2274Phosphotyrosine(INSR)HMM predict
2294Phosphoserine(ATM)HMM predict
2334Phosphotyrosine(INSR)HMM predict
2342Phosphotyrosine(INSR)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_002944
  • Location:chr6 117716222-117853710
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
ER E2-MCF7GSE14664 117863497 117863550 53 9813
Oct1 H2O2-HelaGSE14283 117856111 117856138 27 2414
Oct1 HelaGSE14283 117859367 117859395 28 5671
Oct1 HelaGSE14283 117863498 117863546 48 9812
TFAP2C MCF7GSE21234 117868632 117869264 632 15238
hScc1 BcellGSE12603 117873416 117873652 236 19824
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 117773998 117774289 291 0
CTCF CD4SISSRdata 117773998 117774289 291 0
CTCF G2GSE9613 117780400 117780720 320 0
ER E2-MCF7GSE14664 117787068 117787100 32 0
ER E2-MCF7GSE14664 117832423 117832475 52 0
ER Fulvestrant-MCF7GSE14664 117787066 117787099 33 0
FOXA1 MCF7GSE15244 117815223 117815988 765 0
KLF4 hESGSE17917 117773309 117773476 167 0
Oct1 H2O2-HelaGSE14283 117722436 117722469 33 0
Oct1 H2O2-HelaGSE14283 117795066 117795093 27 0
Oct1 H2O2-HelaGSE14283 117803048 117803078 30 0
Oct1 H2O2-HelaGSE14283 117835554 117835583 29 0
Oct1 H2O2-HelaGSE14283 117839237 117839265 28 0
Oct1 H2O2-HelaGSE14283 117839988 117840070 82 0
Oct1 HelaGSE14283 117722439 117722474 35 0
Oct1 HelaGSE14283 117781562 117781593 31 0
Oct1 HelaGSE14283 117787063 117787093 30 0
Oct1 HelaGSE14283 117803048 117803078 30 0
Oct1 HelaGSE14283 117839765 117839808 43 0
Oct1 HelaGSE14283 117839988 117840020 32 0
hScc1 BcellGSE12603 117813503 117813641 138 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-let-7a hsa-let-7a-1 9 20806079
hsa-let-7a hsa-let-7a-2 11 20806079
hsa-let-7a hsa-let-7a-3 22 20806079
hsa-let-7b hsa-let-7b 22 20806079
hsa-let-7b* hsa-let-7b 22 20806079
hsa-let-7d hsa-let-7d 9 20806079
hsa-let-7d* hsa-let-7d 9 20806079
hsa-let-7e hsa-let-7e 19 20806079
hsa-let-7e* hsa-let-7e 19 20806079
hsa-miR-10b hsa-mir-10b 2 21241449
hsa-miR-10b* hsa-mir-10b 2 21241449
hsa-miR-125b hsa-mir-125b-1 11 20806079
hsa-miR-125b hsa-mir-125b-2 21 20806079
hsa-miR-125b hsa-mir-125b-1 11 17629564
hsa-miR-125b hsa-mir-125b-2 21 17629564
hsa-miR-128 hsa-mir-128-1 2 17629564
hsa-miR-128 hsa-mir-128-2 3 17629564
hsa-miR-146a hsa-mir-146a 5 21262328
hsa-miR-146a hsa-mir-146a 5 19540598
hsa-miR-146a* hsa-mir-146a 5 21262328
hsa-miR-146a* hsa-mir-146a 5 19540598
hsa-miR-15b hsa-mir-15b 3 20806079
hsa-miR-15b* hsa-mir-15b 3 20806079
hsa-miR-16 hsa-mir-16-1 13 20806079
hsa-miR-16 hsa-mir-16-2 3 20806079
hsa-miR-17 hsa-mir-17 13 19597473
hsa-miR-17* hsa-mir-17 13 19597473
hsa-miR-20a hsa-mir-20a 13 19597473
hsa-miR-20a* hsa-mir-20a 13 19597473
hsa-miR-21 hsa-mir-21 17 19336275
hsa-miR-21 hsa-mir-21 17 19158092
hsa-miR-21* hsa-mir-21 17 21350856
hsa-miR-21* hsa-mir-21 17 19336275
hsa-miR-21* hsa-mir-21 17 19158092
hsa-miR-210 hsa-mir-210 11 20732359
hsa-miR-210 hsa-mir-210 11 20498629
hsa-miR-210 hsa-mir-210 11 20436681
hsa-miR-23a hsa-mir-23a 19 20806079
hsa-miR-23a* hsa-mir-23a 19 20806079
hsa-miR-23b hsa-mir-23b 9 21241449
hsa-miR-23b hsa-mir-23b 9 20806079
hsa-miR-23b* hsa-mir-23b 9 21241449
hsa-miR-23b* hsa-mir-23b 9 20806079
hsa-miR-24 hsa-mir-24-1 9 20806079
hsa-miR-24 hsa-mir-24-2 19 20806079
hsa-miR-24-2* hsa-mir-24-2 19 21350856
hsa-miR-26b hsa-mir-26b 2 20806079
hsa-miR-26b* hsa-mir-26b 2 20806079
hsa-miR-27a hsa-mir-27a 19 21156786
hsa-miR-27a hsa-mir-27a 19 20488920
hsa-miR-27a* hsa-mir-27a 19 21350856
hsa-miR-27a* hsa-mir-27a 19 21156786
hsa-miR-27a* hsa-mir-27a 19 20488920
hsa-miR-27b* hsa-mir-27b 9 21350856
hsa-miR-9 hsa-mir-9-1 1 20806079
hsa-miR-9 hsa-mir-9-2 5 20806079
hsa-miR-9 hsa-mir-9-3 15 20806079
hsa-miR-9 hsa-mir-9-1 1 17629564
hsa-miR-9 hsa-mir-9-2 5 17629564
hsa-miR-9 hsa-mir-9-3 15 17629564
hsa-miR-9* hsa-mir-9-1 1 20806079
hsa-miR-92a hsa-mir-92a-1 13 19597473
hsa-miR-92a hsa-mir-92a-2 X 19597473
No data
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
23096 EST chr6 117738820 117742018 78 mRNA ROS1 chr6 117716222 117853711Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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