Annotation Detail for HCN2

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Basic Information Top

Gene Symbol:	HCN2 ( BCNG-2,BCNG2,HAC-1 )
Gene Full Name:	hyperpolarization activated cyclic nucleotide-gated potassium channel 2
Band:	19p13.3
Quick Links	Entrez ID:610; OMIM: 602781; Uniprot ID:HCN2_HUMAN; ENSEMBL ID: ENSG00000099822; HGNC ID: 4846
Relate to Another Database:	SFARIGene; denovo-db

Post Translation Modification

Location(AA)	Modification
146	Phosphoserine (By similarity).
407	N-linked (GlcNAc...) (Potential).
779	Phosphoserine (By similarity).

Location(AA)	Modifications	Resource
146	Phosphoserine (By similarity).	Swiss-Prot 53.0
407	N-linked (GlcNAc...) (Potential).	Swiss-Prot 53.0
779	Phosphoserine (By similarity).	Swiss-Prot 53.0

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CTCF	G2	GSE9613	539262	539968	706	1278
TFAP2C	MCF7	GSE21234	538986	539581	595	1609
hScc1	Bcell	GSE12603	539149	539524	375	1556

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length
CTCF	G2	GSE9613	541727	542463	736
CTCF	G2	GSE9613	556316	556899	583
CTCF	G2	GSE9613	561294	561768	474
CTCF	G2	GSE9613	562226	562564	338
CTCF	G2	GSE9613	567777	567979	202
ETS1	Jurkat	GSE17954	561634	562782	1148
NRSF	Jurkat	GSE13047	541977	543475	1498
NRSF-mono	Jurkat	QuESTdata	541431	542987	1556
NRSF-poly	Jurkat	QuESTdata	541788	543152	1364
P300	T0-glioblastoma	GSE21026	562442	562872	430
SRF	GMO	GSE8489	542163	542658	495
TAF	k562	GSE8489	548613	548885	272
USF1	HepG2	E	548415	548916	501
hScc1	Bcell	GSE12603	541684	542203	519
hScc1	Bcell	GSE12603	546230	546455	225
hScc1	Bcell	GSE12603	552834	553072	238
hScc1	Bcell	GSE12603	554464	554785	321
hScc1	Bcell	GSE12603	561433	561768	335
hScc1	Bcell	GSE12603	563982	564839	857
hScc1	Bcell	GSE12603	566645	567323	678
hScc1	Bcell	GSE12603	567777	568187	410
p130	shRbSenescent	GSE19898	562464	562619	155

Validated miRNA targets

Micro RNA Name	Stem Loop Name	The chromosome that miRNA located	Publication
hsa-miR-1	hsa-mir-1-2	18	19136465
hsa-miR-1	hsa-mir-1-1	20	19136465
hsa-miR-1	hsa-mir-1-2	18	17516552
hsa-miR-1	hsa-mir-1-1	20	17516552
hsa-miR-133a	hsa-mir-133a-1	18	19136465
hsa-miR-133a	hsa-mir-133a-2	20	19136465
hsa-miR-133a	hsa-mir-133a-1	18	17516552
hsa-miR-133a	hsa-mir-133a-2	20	17516552
hsa-miR-133b	hsa-mir-133b	6	19136465
hsa-miR-133b	hsa-mir-133b	6	17516552
hsa-miR-155	hsa-mir-155	21	19136465
hsa-miR-155*	hsa-mir-155	21	19136465
hsa-miR-17	hsa-mir-17	13	19136465
hsa-miR-17*	hsa-mir-17	13	19136465
hsa-miR-21	hsa-mir-21	17	19136465
hsa-miR-21*	hsa-mir-21	17	19136465

ID in Tarbase	Data Type	Support Type	miRNA	Gene	Direct Support	Publication
222	mRNA repression	TRUE	miR-1	HCN2	Luciferase assay - mutant MRE	18458081
452	mRNA repression	TRUE	miR-133	HCN2	Luciferase assay - mutant MRE	18458081
Ensembl	Protein Type	Differentially expressed in	Pathology or Event	Mis Regulation	Gene Expression	Tumour Involvement
ENSG00000099822		"cardiac and skeletal muscles, cardiogenesis"	cardiac hypertrophy	down regulated	n_a	"malignant tumour, leukaemia"
ENSG00000099822		"cardiac and skeletal muscles, cardiogenesis"	cardiac hypertrophy	down regulated	n_a	"malignant tumour, leukaemia"

Cis-Nats regulation

Simple Query:

Paper Collected: 6/30/2018

Last Update: 8/26/2018