AutismKB 2.0

Annotation Detail for RPS6KA1


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Basic Information Top
Gene Symbol:RPS6KA1 ( HU-1,MAPKAPK1A,RSK,RSK1 )
Gene Full Name: ribosomal protein S6 kinase, 90kDa, polypeptide 1
Band: 1p36.11
Quick LinksEntrez ID:6195; OMIM: 601684; Uniprot ID:KS6A1_HUMAN; ENSEMBL ID: ENSG00000117676; HGNC ID: 10430
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
25Phosphothreonine.
26Phosphoserine.
54Phosphoserine.
72Phosphoserine.
204Phosphothreonine.
209Phosphoserine.
220Phosphotyrosine.
221Phosphoserine.
225Phosphothreonine.
307Phosphoserine.
348Phosphothreonine.
359Phosphothreonine.
363Phosphoserine.
369Phosphoserine.
380Phosphoserine; by autocatalysis.
573Phosphothreonine.
576Phosphotyrosine.
635Phosphothreonine.
637Phosphoserine.
684Phosphoserine.
732Phosphoserine.
Location(AA) Modifications Resource
221Phosphoserine.Swiss-Prot 53.0
221Phosphoserine (RSK
225Phosphothreonine.Swiss-Prot 53.0
348Phosphothreonine.Swiss-Prot 53.0
359Phosphothreonine.Swiss-Prot 53.0
359Phosphothreonine (MAPK
363Phosphoserine (MAPK
363Phosphoserine.Swiss-Prot 53.0
369Phosphoserine.Swiss-Prot 53.0
380Phosphoserine (by autocatalysis).Swiss-Prot 53.0
573Phosphothreonine.Swiss-Prot 53.0
573PhosphothreoninePhospho.ELM 6.0
732Phosphoserine.Swiss-Prot 53.0
732PhosphoserinePhospho.ELM 6.0
Location(AA) Modification Resource
26Phosphoserine(CK2)HMM predict
54Phosphoserine(CK2)HMM predict
83Phosphothreonine(PKA)HMM predict
83Phosphothreonine(PKC)HMM predict
91Phosphotyrosine(Abl)HMM predict
109Phosphothreonine(PKC)HMM predict
154Phosphoserine(PKG)HMM predict
221Phosphoserine(IKK)HMM predict
228Phosphotyrosine(INSR)HMM predict
228Phosphotyrosine(SRC)HMM predict
350Phosphotyrosine(Syk)HMM predict
350SulfotyrosineHMM predict
363Phosphoserine(CDC2)HMM predict
369O-linkedHMM predict
380Phosphoserine(PKA)HMM predict
457PhosphoserineHMM predict
457Phosphoserine(CK2)HMM predict
479Phosphotyrosine(Syk)HMM predict
486Phosphotyrosine(Syk)HMM predict
528Phosphoserine(ATM)HMM predict
573PhosphothreonineHMM predict
621Phosphothreonine(MAPK)HMM predict
676Phosphothreonine(PKC)HMM predict
684Phosphoserine(ATM)HMM predict
706N-linkedHMM predict
711Phosphothreonine(CDK)HMM predict
711Phosphothreonine(CDC2)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_001006665
  • Location:chr1 26744929-26774106
  • strand:+
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 26783281 26783523 242 9296
Myc K562GSE19551 26783110 26783672 562 9285
NFkBII GM12878GSE19485 26778318 26782607 4289 6356
NFkBII GM12892GSE19485 26779629 26780752 1123 6084
NFkBII GM15510GSE19485 26779556 26780762 1206 6053
hScc1 BcellGSE12603 26780217 26780421 204 6213
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 26744851 26745145 294 0
CTCF G2GSE9613 26745567 26746124 557 0
CTCF G2GSE9613 26772248 26772627 379 0
CTCF G2GSE9613 26773047 26773213 166 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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