AutismKB 2.0

Annotation Detail for RPS6KA3


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Basic Information Top
Gene Symbol:RPS6KA3 ( CLS,HU-3,ISPK-1,MAPKAPK1B,MRX19,RSK,RSK2,S6K-alpha3,p90-RSK2,pp90RSK2 )
Gene Full Name: ribosomal protein S6 kinase, 90kDa, polypeptide 3
Band: Xp22.12
Quick LinksEntrez ID:6197; OMIM: 300075; Uniprot ID:KS6A3_HUMAN; ENSEMBL ID: ENSG00000177189; HGNC ID: 10432
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
17Phosphoserine.
19Phosphoserine.
226Phosphotyrosine.
227Phosphoserine.
231Phosphothreonine.
365Phosphothreonine.
369Phosphoserine.
375Phosphoserine.
386Phosphoserine.
391Phosphothreonine.
415Phosphoserine.
556Phosphoserine.
577Phosphothreonine (By similarity).
715Phosphoserine.
737Phosphoserine.
Location(AA) Modifications Resource
227Phosphoserine.Swiss-Prot 53.0
227PhosphoserinePhospho.ELM 6.0
231Phosphothreonine.Swiss-Prot 53.0
365Phosphothreonine.Swiss-Prot 53.0
365PhosphothreoninePhospho.ELM 6.0
369Phosphoserine.Swiss-Prot 53.0
369PhosphoserinePhospho.ELM 6.0
386Phosphoserine (By similarity).Swiss-Prot 53.0
386PhosphoserinePhospho.ELM 6.0
577Phosphothreonine (MAPK3)Phospho.ELM 6.0
577Phosphothreonine (By similarity).Swiss-Prot 53.0
707Phosphotyrosine (FGFR1)Phospho.ELM 6.0
715Phosphoserine.Swiss-Prot 53.0
737Phosphoserine (By similarity).Swiss-Prot 53.0
Location(AA) Modification Resource
19Phosphoserine(CK2)HMM predict
66Phosphoserine(ATM)HMM predict
115Phosphothreonine(PKC)HMM predict
160Phosphoserine(PKG)HMM predict
227Phosphoserine(IKK)HMM predict
234Phosphotyrosine(INSR)HMM predict
234Phosphotyrosine(SRC)HMM predict
246Phosphothreonine(PKA)HMM predict
292Phosphoserine(IKK)HMM predict
292Phosphoserine(CDC2)HMM predict
356Phosphotyrosine(Syk)HMM predict
356SulfotyrosineHMM predict
369Phosphoserine(CDC2)HMM predict
386Phosphoserine(PKA)HMM predict
439S-palmitoylHMM predict
483Phosphotyrosine(Syk)HMM predict
577PhosphothreonineHMM predict
625Phosphothreonine(MAPK)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_004586
  • Location:chrX 20077950-20194670
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 20194899 20195236 337 397
Oct1 HelaGSE14283 20206983 20207025 42 12334
hScc1 CdLSGSE12603 20194598 20195678 1080 468
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 20180984 20181236 252 0
CTCF CD4SISSRdata 20180984 20181236 252 0
FOXA1 MCF7GSE15244 20145928 20146250 322 0
H3ac HepG2E 20193003 20194058 1055 0
Oct1 HelaGSE14283 20099629 20099662 33 0
Oct1 HelaGSE14283 20103966 20104005 39 0
Oct1 HelaGSE14283 20145502 20145533 31 0
TAF k562GSE8489 20192734 20194058 1324 0
TAFII hESGSE17917 20181080 20181313 233 0
TFAP2C MCF7GSE21234 20087866 20088172 306 0
hScc1 BcellGSE12603 20180915 20181239 324 0
hScc1 BcellGSE12603 20193922 20195289 1367 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018