AutismKB 2.0

Annotation Detail for RPS6KB1


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Basic Information Top
Gene Symbol:RPS6KB1 ( PS6K,S6K,S6K1,STK14A,p70(S6K)-alpha,p70-S6K,p70-alpha )
Gene Full Name: ribosomal protein S6 kinase, 70kDa, polypeptide 1
Band: 17q23.1
Quick LinksEntrez ID:6198; OMIM: 608938; Uniprot ID:KS6B1_HUMAN; ENSEMBL ID: ENSG00000108443; HGNC ID: 10436
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
32TOS motif.
252Phosphothreonine; by PDPK1 (Probable).
304N6-acetyllysine.
394Phosphoserine.
412Phosphothreonine.
441Phosphoserine.
444Phosphothreonine.
447Phosphoserine.
Location(AA) Modifications Resource
252Phosphothreonine (PDK-1)Phospho.ELM 6.0
390Phosphothreonine (mTOR;PDK-1)Phospho.ELM 6.0
394Phosphoserine (CDK1;mTOR)Phospho.ELM 6.0
412Phosphothreonine (mTOR;p70S6K;)Phospho.ELM 6.0
427Phosphoserine (PDK-1)Phospho.ELM 6.0
434Phosphoserine (CDK1;mTOR;PD)Phospho.ELM 6.0
441Phosphoserine.Swiss-Prot 53.0
441Phosphoserine (PDK-1)Phospho.ELM 6.0
444Phosphothreonine (CDK1;mTOR)Phospho.ELM 6.0
444Phosphothreonine.Swiss-Prot 53.0
447Phosphoserine (CDK1;mTOR)Phospho.ELM 6.0
447Phosphoserine.Swiss-Prot 53.0
470Phosphothreonine (PDK-1)Phospho.ELM 6.0
Location(AA) Modification Resource
40Phosphoserine(CK2)HMM predict
40PhosphoserineHMM predict
40Phosphoserine(CK1)HMM predict
102Phosphotyrosine(EGFR)HMM predict
112Phosphothreonine(PKA)HMM predict
252O-linkedHMM predict
252PhosphothreonineHMM predict
259Phosphotyrosine(INSR)HMM predict
301Phosphothreonine(PKC)HMM predict
380Phosphoserine(ATM)HMM predict
390PhosphothreonineHMM predict
390Phosphothreonine(PKA)HMM predict
401Phosphoserine(CK2)HMM predict
401Phosphoserine(CK1)HMM predict
413Phosphotyrosine(Jak)HMM predict
434PhosphoserineHMM predict
441Phosphoserine(CDC2)HMM predict
441Phosphoserine(CDK)HMM predict
444Phosphothreonine(CDK)HMM predict
444Phosphothreonine(CDC2)HMM predict
447Phosphoserine(CDC2)HMM predict
464O-linkedHMM predict
465O-linkedHMM predict
470PhosphothreonineHMM predict
470Phosphothreonine(MAPK)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_003161
  • Location:chr17 55325224-55382565
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
ETS1 JurkatGSE17954 55324416 55325888 1472 73
HIF1 HypoHepG2 55324803 55325568 765 39
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T0-glioblastomaGSE21026 55341109 55341433 324 0
CBP T30-glioblastomaGSE21026 55340924 55341685 761 0
CTCF CD4GSE12889 55346482 55346814 332 0
CTCF CD4SISSRdata 55346482 55346814 332 0
CTCF G2GSE9613 55325140 55325537 397 0
CTCF G2GSE9613 55346322 55346781 459 0
FOXA1 MCF7GSE15244 55324551 55326045 1494 0
H3K4me3 colorectalcancer 55325537 55326696 1159 0
H3ac HepG2E 55324161 55326696 2535 0
Nanog hESGSE18292 55346538 55346790 252 0
P300 T0-glioblastomaGSE21026 55341126 55341766 640 0
P300 T30-glioblastomaGSE21026 55341213 55341613 400 0
PHF8 Hs68plusFBSGSE20725 55324756 55326172 1416 0
RARA MCF7GSE15244 55324161 55326661 2500 0
RARA MCF7GSE15244 55331375 55331629 254 0
RARA MCF7GSE15244 55344035 55344268 233 0
RARG MCF7GSE15244 55325806 55326696 890 0
TAF k562GSE8489 55325877 55326696 819 0
TAFII hESGSE17917 55325023 55325498 475 0
hScc1 CdLSGSE12603 55346322 55346861 539 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-145 hsa-mir-145 5 20382746
hsa-miR-145* hsa-mir-145 5 20382746
hsa-miR-21 hsa-mir-21 17 18335499
hsa-miR-21* hsa-mir-21 17 18335499
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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