AutismKB 2.0

Annotation Detail for RRM2


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Basic Information Top
Gene Symbol:RRM2 ( R2,RR2,RR2M )
Gene Full Name: ribonucleotide reductase M2
Band: 2p25.1
Quick LinksEntrez ID:6241; OMIM: 180390; Uniprot ID:RIR2_HUMAN; ENSEMBL ID: ENSG00000171848; HGNC ID: 10452
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
20Phosphoserine.
33Phosphothreonine.
377Phosphoserine.
Location(AA) Modifications Resource
20Phosphoserine.Swiss-Prot 53.0
20Phosphoserine (CDK1)Phospho.ELM 6.0
Location(AA) Modification Resource
20Phosphoserine(CDC2)HMM predict
20Phosphoserine(CDK)HMM predict
33Phosphothreonine(MAPK)HMM predict
110Phosphoserine(CK1)HMM predict
150Phosphoserine(CK1)HMM predict
221Phosphotyrosine(SRC)HMM predict
237Phosphoserine(CDK)HMM predict
316N-linkedHMM predict
377Phosphoserine(CDC2)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_001034
  • Location:chr2 10180185-10188072
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 10160820 10161029 209 19261
CTCF G2GSE9613 10177665 10178334 669 2186
Fos K562GSE19551 10179345 10180579 1234 224
H3K4me2 HCT116GSE10453 10178816 10179507 691 1024
H3ac HepG2E 10178442 10179687 1245 1121
HIF1 HypoHepG2 10177665 10178584 919 2061
LIN9 G0GSE7516 10177806 10178370 564 2098
Oct1 HelaGSE14283 10174256 10174296 40 5910
PHF8 HeLaGSE20725 10179356 10180991 1635 12
Rb GrowingGSE19898 10178215 10178399 184 1879
Rb QuiescentGSE19898 10177847 10178184 337 2170
Rb SenescentGSE19898 10177852 10178336 484 2092
Rb shRbSenescenceGSE19898 10177900 10178115 215 2178
TAF HelaGSE8489 10178213 10178649 436 1755
TAF HelaGSE8489 10178939 10179651 712 891
TAF k562GSE8489 10178213 10179687 1474 1236
TFAP2C MCF7GSE21234 10160551 10161194 643 19313
hScc1 BcellGSE12603 10177945 10178334 389 2046
p130 QuiescentGSE19898 10177777 10178110 333 2242
p130 QuiescentGSE19898 10178128 10178412 284 1916
p130 QuiescentGSE19898 10179787 10179984 197 300
p130 SenescentGSE19898 10177734 10178345 611 2146
p130 shRbQuiescentGSE19898 10179330 10179808 478 617
p130 shRbSenescentGSE19898 10177822 10178522 700 2014
p130 shRbSenescentGSE19898 10179356 10179963 607 526
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 10190357 10190517 160 2365
Oct1 HelaGSE14283 10188934 10188971 37 880
Oct4 hESGSE17917 10190904 10191311 407 3035
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 10182094 10182460 366 0
CTCF CD4SISSRdata 10182094 10182460 366 0
CTCF G2GSE9613 10179904 10180746 842 0
CTCF G2GSE9613 10182257 10182982 725 0
E2F4 G0GSE7516 10179904 10181445 1541 0
E2F4 SGSE7516 10180022 10181408 1386 0
H3K4me3 colorectalcancer 10180869 10181445 576 0
H3ac HepG2E 10180711 10181657 946 0
LIN54 G0GSE7516 10180022 10181377 1355 0
LIN9 G0GSE7516 10179904 10181635 1731 0
LIN9 SGSE7516 10179006 10181657 2651 0
Oct1 H2O2-HelaGSE14283 10181255 10181286 31 0
Oct1 HelaGSE14283 10181255 10181286 31 0
Pol2 GM12878GSE19551 10180036 10180907 871 0
Rb SenescentGSE19898 10180079 10180974 895 0
Rb shRbSenescenceGSE19898 10180511 10180790 279 0
TAF HelaGSE8489 10180869 10181556 687 0
TAF k562GSE8489 10180825 10181657 832 0
TAF k562GSE8489 10182773 10183564 791 0
hScc1 BcellGSE12603 10180379 10180956 577 0
hScc1 BcellGSE12603 10182064 10182517 453 0
hScc1 CdLSGSE12603 10182021 10182703 682 0
p130 QuiescentGSE19898 10180083 10180836 753 0
p130 SenescentGSE19898 10179386 10181617 2231 0
p130 shRbQuiescentGSE19898 10179988 10180956 968 0
p130 shRbSenescentGSE19898 10180063 10181309 1246 0
p130 G0GSE7516 10179156 10181556 2400 0
p130 SGSE7516 10179982 10181193 1211 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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