Annotation Detail for MAPK12
Basic Information Top
| Gene Symbol: | MAPK12 ( ERK3,ERK6,P38GAMMA,PRKM12,SAPK-3,SAPK3 ) |
|---|---|
| Gene Full Name: | mitogen-activated protein kinase 12 |
| Band: | 22q13.33 |
| Quick Links | Entrez ID:6300; OMIM: 602399; Uniprot ID:MK12_HUMAN; ENSEMBL ID: ENSG00000188130; HGNC ID: 6874 |
| Relate to Another Database: | SFARIGene; denovo-db |
| Location(AA) | Modification | |
|---|---|---|
| 3 | Phosphoserine. | |
| 27 | Phosphotyrosine. | |
| 183 | Phosphothreonine (By similarity). | |
| 185 | Phosphotyrosine. | |
| 185 | TXY. | |
| Location(AA) | Modifications | Resource |
|---|---|---|
| 3 | Phosphoserine (MAPK12) | Phospho.ELM 6.0 |
| 27 | Phosphotyrosine. | Swiss-Prot 53.0 |
| 27 | Phosphotyrosine | Phospho.ELM 6.0 |
| 183 | Phosphothreonine (By similarity). | Swiss-Prot 53.0 |
| 183 | Phosphothreonine (MAP2K3;MAP2K) | Phospho.ELM 6.0 |
| 185 | Phosphotyrosine. | Swiss-Prot 53.0 |
| 185 | Phosphotyrosine (MAP2K3;MAP2K) | Phospho.ELM 6.0 |
| Location(AA) | Modification | Resource |
|---|---|---|
| 72 | Phosphotyrosine(EGFR) | HMM predict |
| 244 | Phosphothreonine(MAPK) | HMM predict |
| 261 | Phosphotyrosine(INSR) | HMM predict |
| 281 | Phosphoserine(CDC2) | HMM predict |
| 344 | Phosphothreonine(PKC) | HMM predict |
| 362 | Phosphoserine(PKG) | HMM predict |
- RefSeq ID: NM_002969
- Location:chr22 49033457-49042215
- strand:-
| Transcrip Factors | Experimental Cell | Database | TF Binding Start | TF Binding End | TF Binding Length | The Distance to Gene |
|---|---|---|---|---|---|---|
| H3K4me3 | colorectal | cancer | 49042087 | 49042388 | 301 | 22 |
| Transcrip Factors | Experimental Cell | Database | TF Binding Start | TF Binding End | TF Binding Length | The Distance to Gene |
|---|---|---|---|---|---|---|
| CTCF | CD4 | GSE12889 | 49032758 | 49033069 | 311 | 544 |
| CTCF | CD4 | SISSRdata | 49032758 | 49033069 | 311 | 544 |
| CTCF | Hela | GSE12889 | 49032795 | 49032970 | 175 | 575 |
| CTCF | Jurkat | GSE12889 | 49032831 | 49033016 | 185 | 534 |
| CTCF | G2 | GSE9613 | 49032741 | 49033038 | 297 | 568 |
| hScc1 | CdLS | GSE12603 | 49032647 | 49033038 | 391 | 615 |
| Transcrip Factors | Experimental Cell | Database | TF Binding Start | TF Binding End | TF Binding Length | The Distance to Gene |
|---|---|---|---|---|---|---|
| PHF8 | HeLa | GSE20725 | 49040981 | 49042718 | 1737 | 0 |
| Rb | Senescent | GSE19898 | 49041626 | 49041803 | 177 | 0 |
| TFAP2C | MCF7 | GSE21234 | 49034450 | 49034858 | 408 | 0 |
| hScc1 | Bcell | GSE12603 | 49036989 | 49037409 | 420 | 0 |
| hScc1 | Bcell | GSE12603 | 49041080 | 49042989 | 1909 | 0 |
| No data |
| ID in Tarbase | Data Type | Support Type | miRNA | Gene | Direct Support | Publication |
|---|---|---|---|---|---|---|
| 463 | mRNA repression | TRUE | miR-143 | MAPK12 / ERK5 | n_a | 15504739 |
| Ensembl | Protein Type | Differentially expressed in | Pathology or Event | Mis Regulation | Gene Expression | Tumour Involvement |
| ENSG00000188130 | B cells | n_a | n_a | "lymphocyte, muscle cell" | "benign tumour, malignant tumour, carcinoma, leukaemia, sarcoma" |
Cis-Nats regulation