AutismKB 2.0

Annotation Detail for SCN10A


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Basic Information Top
Gene Symbol:SCN10A ( Nav1.8,PN3,SNS,hPN3 )
Gene Full Name: sodium channel, voltage-gated, type X, alpha subunit
Band: 3p22.2
Quick LinksEntrez ID:6336; OMIM: 604427; Uniprot ID:SCNAA_HUMAN; ENSEMBL ID: ENSG00000185313; HGNC ID: 10582
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
284N-linked (GlcNAc...) (Potential).
288N-linked (GlcNAc...) (Potential).
312N-linked (GlcNAc...) (Potential).
335N-linked (GlcNAc...) (Potential).
819N-linked (GlcNAc...) (Potential).
1312N-linked (GlcNAc...) (Potential).
1328N-linked (GlcNAc...) (Potential).
1336N-linked (GlcNAc...) (Potential).
1686N-linked (GlcNAc...) (Potential).
Location(AA) Modifications Resource
284N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
288N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
312N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
335N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
819N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1312N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1328N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1336N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1686N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
Location(AA) Modification Resource
17Phosphothreonine(PKA)HMM predict
34Phosphothreonine(PKC)HMM predict
284N-linkedHMM predict
288N-linkedHMM predict
298Phosphotyrosine(INSR)HMM predict
304Phosphothreonine(PKC)HMM predict
304Phosphothreonine(PKA)HMM predict
312N-linkedHMM predict
335N-linkedHMM predict
336SulfotyrosineHMM predict
407Phosphothreonine(CK2)HMM predict
446N-linkedHMM predict
448Phosphoserine(CDC2)HMM predict
454N-linkedHMM predict
470Phosphoserine(CK1)HMM predict
471Phosphothreonine(CK2)HMM predict
474N-linkedHMM predict
488PhosphoserineHMM predict
500Phosphoserine(PKG)HMM predict
500Phosphoserine(PKA)HMM predict
552Phosphoserine(IKK)HMM predict
552Phosphoserine(CDC2)HMM predict
575O-linkedHMM predict
600Phosphotyrosine(Syk)HMM predict
612PhosphoserineHMM predict
634S-palmitoylHMM predict
819N-linkedHMM predict
897N-linkedHMM predict
954Phosphoserine(CDC2)HMM predict
956Phosphoserine(IKK)HMM predict
990N-linkedHMM predict
1004Phosphoserine(CK2)HMM predict
1044Phosphothreonine(CDC2)HMM predict
1047Phosphoserine(CDC2)HMM predict
1053O-linkedHMM predict
1082Phosphoserine(CK1)HMM predict
1083Phosphoserine(CK1)HMM predict
1087Phosphoserine(IKK)HMM predict
1088Phosphothreonine(PKC)HMM predict
1174SulfotyrosineHMM predict
1175Phosphotyrosine(Syk)HMM predict
1181Phosphothreonine(PKC)HMM predict
1251Phosphothreonine(PKC)HMM predict
1312N-linkedHMM predict
1328N-linkedHMM predict
1336N-linkedHMM predict
1393Phosphotyrosine(INSR)HMM predict
1393Phosphotyrosine(Syk)HMM predict
1393Phosphotyrosine(SRC)HMM predict
1442Phosphotyrosine(Syk)HMM predict
1443Phosphotyrosine(Syk)HMM predict
1686N-linkedHMM predict
1745SulfotyrosineHMM predict
1833N-linkedHMM predict
1839Phosphotyrosine(INSR)HMM predict
1839Phosphotyrosine(Syk)HMM predict
1845Phosphothreonine(PKC)HMM predict
1915O-linkedHMM predict
1916Phosphoserine(IKK)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_006514
  • Location:chr3 38713841-38810504
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Myc K562GSE19551 38822355 38822661 306 12004
NRSF JurkatGSE13047 38821086 38823243 2157 11660
NRSF mAbJurkat 38810501 38815247 4746 2370
NRSF mAbJurkat 38815586 38818989 3403 6783
NRSF mAbJurkat 38820316 38827454 7138 13381
NRSF mAbJurkat 38828274 38828843 569 18054
NRSF-mono JurkatQuESTdata 38821441 38823245 1804 11839
NRSF-poly JurkatQuESTdata 38821031 38823223 2192 11623
Oct1 HelaGSE14283 38810496 38810542 46 15
Rb SenescentGSE19898 38822391 38822629 238 12006
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 38695275 38695496 221 18456
Oct1 HelaGSE14283 38712181 38712229 48 1637
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T0-glioblastomaGSE21026 38735700 38736043 343 0
CTCF G2GSE9613 38723806 38724022 216 0
CTCF G2GSE9613 38724943 38725120 177 0
CTCF G2GSE9613 38735060 38735309 249 0
CTCF G2GSE9613 38740070 38740297 227 0
CTCF G2GSE9613 38741480 38741806 326 0
CTCF G2GSE9613 38743657 38743899 242 0
CTCF G2GSE9613 38755048 38755445 397 0
CTCF G2GSE9613 38758627 38758852 225 0
Gata2 K562GSE18868 38740367 38741159 792 0
NRSF JurkatGSE13047 38771379 38772348 969 0
NRSF mAbJurkat 38761420 38762970 1550 0
NRSF mAbJurkat 38764532 38765842 1310 0
NRSF mAbJurkat 38768195 38772620 4425 0
NRSF mAbJurkat 38773035 38775051 2016 0
NRSF mAbJurkat 38778096 38779381 1285 0
NRSF mAbJurkat 38805314 38806252 938 0
NRSF-mono JurkatQuESTdata 38771378 38772282 904 0
NRSF-poly JurkatQuESTdata 38771459 38772333 874 0
Oct1 H2O2-HelaGSE14283 38792215 38792265 50 0
Oct1 HelaGSE14283 38761682 38761713 31 0
Oct1 HelaGSE14283 38792213 38792262 49 0
Oct4 hESGSE17917 38755259 38755486 227 0
TFAP2C MCF7GSE21234 38740906 38741347 441 0
hScc1 G2GSE9613 38755048 38755445 397 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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