AutismKB 2.0

Annotation Detail for SDC4


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Basic Information Top
Gene Symbol:SDC4 ( MGC22217,SYND4 )
Gene Full Name: syndecan 4
Band: 20q13.12
Quick LinksEntrez ID:6385; OMIM: 600017; Uniprot ID:SDC4_HUMAN; ENSEMBL ID: ENSG00000124145; HGNC ID: 10661
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
39O-linked (Xyl...) (heparan sulfate) (By
61O-linked (Xyl...) (heparan sulfate)
63O-linked (Xyl...) (heparan sulfate)
197Phosphotyrosine.
Location(AA) Modifications Resource
39O-linked (Xyl...) (heparan sulfate) (Bysimilarity).Swiss-Prot 53.0
61O-linked (Xyl...) (heparan sulfate)(Potential).Swiss-Prot 53.0
63O-linked (Xyl...) (heparan sulfate)(Potential).Swiss-Prot 53.0
179PhosphoserinePhospho.ELM 6.0
Location(AA) Modification Resource
61Phosphoserine(CK2)HMM predict
95O-linkedHMM predict
95Phosphoserine(CK1)HMM predict
95Phosphoserine(IKK)HMM predict
97Phosphoserine(IKK)HMM predict
97Phosphoserine(ATM)HMM predict
117Phosphoserine(MAPK)HMM predict
117Phosphoserine(CDC2)HMM predict
130Phosphoserine(IKK)HMM predict
132Phosphoserine(CK1)HMM predict
188Phosphotyrosine(EGFR)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_002999
  • Location:chr20 43387344-43410477
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 43410430 43410698 268 87
hScc1 BcellGSE12603 43410430 43410698 268 87
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
FoxA1 MCF7MACSdata 43383940 43384350 410 3200
Myc K562GSE19551 43385016 43385412 396 2131
RARA MCF7GSE15244 43384008 43384346 338 3168
TFAP2C MCF7GSE21234 43383768 43384228 460 3347
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
ER MCF7GSE19013 43402352 43402924 572 0
FOXA1 MCF7GSE15244 43403849 43406589 2740 0
FOXA1 eGFPGSE10845 43403849 43406589 2740 0
Fos K562GSE19551 43405889 43406693 804 0
H3ac HepG2E 43398708 43401498 2790 0
H3ac HepG2E 43401880 43405530 3650 0
H3ac HepG2E 43407349 43410179 2830 0
P300 T30-glioblastomaGSE21026 43398515 43400809 2294 0
Pol2 GM12878GSE19551 43410300 43410511 211 0
RARA MCF7GSE15244 43401880 43406589 4709 0
Rb GrowingGSE19898 43399715 43399942 227 0
Sox2 hESGSE18292 43403071 43403311 240 0
TFAP2C MCF7GSE21234 43398470 43399207 737 0
TFAP2C MCF7GSE21234 43403643 43406809 3166 0
TFAP2C MCF7GSE21234 43407477 43408148 671 0
TFAP2C MCF7GSE21234 43408278 43408838 560 0
TFAP2C MCF7GSE21234 43409701 43410328 627 0
USF1 HepG2E 43401928 43405530 3602 0
USF2 HepG2E 43401928 43405562 3634 0
hScc1 BcellGSE12603 43398708 43399143 435 0
hScc1 BcellGSE12603 43399906 43400350 444 0
p130 SenescentGSE19898 43399655 43400267 612 0
p130 shRbQuiescentGSE19898 43398403 43399031 628 0
p130 shRbQuiescentGSE19898 43399291 43400521 1230 0
p130 shRbQuiescentGSE19898 43404344 43404740 396 0
p130 shRbSenescentGSE19898 43399963 43400273 310 0
p130 shRbSenescentGSE19898 43400966 43401214 248 0
p63 keratinocytesGSE17611 43401023 43401880 857 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-1 hsa-mir-1-2 18 15685193
hsa-miR-1 hsa-mir-1-1 20 15685193
hsa-miR-124 hsa-mir-124-1 8 15685193
hsa-miR-124 hsa-mir-124-2 8 15685193
hsa-miR-124 hsa-mir-124-3 20 15685193
hsa-miR-373 hsa-mir-373 19 15685193
hsa-miR-373* hsa-mir-373 19 15685193
ID in Tarbase Data Type Support Type miRNA Gene Direct Support Publication
192 Unknown MicroArray miR-1 SDC4 n_a 15685193
Ensembl Protein Type Differentially expressed in Pathology or Event Mis Regulation Gene Expression Tumour Involvement
ENSG00000124145 "cardiac and skeletal muscles, cardiogenesis" n_a n_a n_a n_a
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018