AutismKB 2.0

Annotation Detail for SDHA


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Basic Information Top
Gene Symbol:SDHA ( FP,SDH1,SDH2,SDHF )
Gene Full Name: succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
Band: 5p15.33
Quick LinksEntrez ID:6389; OMIM: 600857; Uniprot ID:DHSA_HUMAN; ENSEMBL ID: ENSG00000073578; HGNC ID: 10680
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
99Tele-8alpha-FAD histidine (By
179N6-acetyllysine.
252Phosphothreonine (By similarity).
335N6-acetyllysine.
485N6-acetyllysine (By similarity).
498N6-acetyllysine (By similarity).
538N6-acetyllysine (By similarity).
541N6-acetyllysine.
547N6-acetyllysine.
608N6-acetyllysine.
Location(AA) Modifications Resource
99Tele-8alpha-FAD histidine (Bysimilarity).Swiss-Prot 53.0
179N6-acetyllysine (By similarity).Swiss-Prot 53.0
252Phosphothreonine (By similarity).Swiss-Prot 53.0
485N6-acetyllysine (By similarity).Swiss-Prot 53.0
498N6-acetyllysine (By similarity).Swiss-Prot 53.0
538N6-acetyllysine (By similarity).Swiss-Prot 53.0
547N6-acetyllysine (By similarity).Swiss-Prot 53.0
Location(AA) Modification Resource
50Phosphoserine(IKK)HMM predict
169Phosphotyrosine(EGFR)HMM predict
265O-linkedHMM predict
267O-linkedHMM predict
271O-linkedHMM predict
272O-linkedHMM predict
272O-linkedHMM predict
348Phosphothreonine(PKC)HMM predict
597SulfotyrosineHMM predict
606Phosphotyrosine(INSR)HMM predict
606SulfotyrosineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_004168
  • Location:chr5 271446-309791
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 270612 272134 1522 74
Rb SenescentGSE19898 271306 271478 172 55
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T30-glioblastomaGSE21026 316257 318008 1751 7341
CTCF G2GSE9613 310626 311476 850 1260
FOXA1 MCF7GSE15244 310626 311476 850 1260
FOXA1 MCF7GSE15244 311793 312018 225 2114
P300 T0-glioblastomaGSE21026 316221 317183 962 6911
P300 T30-glioblastomaGSE21026 316128 318104 1976 7325
RARA MCF7GSE15244 310626 311476 850 1260
RARA MCF7GSE15244 311793 312018 225 2114
RARA MCF7GSE15244 314720 315211 491 5174
USF2 HepG2E 314720 315211 491 5174
hScc1 BcellGSE12603 310626 311449 823 1246
hScc1 BcellGSE12603 311793 312018 225 2114
hScc1 BcellGSE12603 314720 315211 491 5174
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 289453 289675 222 0
CTCF G2GSE9613 304649 305019 370 0
CTCF G2GSE9613 307813 308036 223 0
H3K4me3 colorectalcancer 272062 273458 1396 0
PHF8 293TGSE20725 270973 272021 1048 0
PHF8 HeLaGSE20725 270605 272495 1890 0
TFAP2C MCF7GSE21234 300641 301252 611 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018