AutismKB 2.0

Annotation Detail for BLK


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Basic Information Top
Gene Symbol:BLK ( MGC10442,MODY11 )
Gene Full Name: B lymphoid tyrosine kinase
Band: 8p23.1
Quick LinksEntrez ID:640; OMIM: 191305; Uniprot ID:BLK_HUMAN; ENSEMBL ID: ENSG00000136573; HGNC ID: 1057
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
389Phosphotyrosine; by autocatalysis (By
Location(AA) Modifications Resource
2N-myristoyl glycine (By similarity).Swiss-Prot 53.0
389Phosphotyrosine (by autocatalysis) (Bysimilarity).Swiss-Prot 53.0
Location(AA) Modification Resource
29O-linkedHMM predict
107Phosphotyrosine(INSR)HMM predict
188Phosphotyrosine(EGFR)HMM predict
188Phosphotyrosine(INSR)HMM predict
217Phosphothreonine(PKA)HMM predict
270Phosphothreonine(PKC)HMM predict
309Phosphotyrosine(Jak)HMM predict
309Phosphotyrosine(SRC)HMM predict
309Phosphotyrosine(INSR)HMM predict
309Phosphotyrosine(EGFR)HMM predict
494Phosphotyrosine(Jak)HMM predict
494Phosphotyrosine(Syk)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_001715
  • Location:chr8 11388929-11459515
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
NFkBII GM12878GSE19485 11378144 11379862 1718 9927
NFkBII GM12892GSE19485 11378113 11379663 1550 10042
hScc1 BcellGSE12603 11381290 11381490 200 7540
hScc1 CdLSGSE12603 11378880 11379177 297 9901
hScc1 CdLSGSE12603 11386670 11387745 1075 1722
p130 SenescentGSE19898 11375483 11375605 122 13386
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 11459482 11459736 254 94
CTCF CD4GSE12889 11462132 11462275 143 2688
CTCF CD4SISSRdata 11459482 11459736 254 94
CTCF CD4SISSRdata 11462132 11462275 143 2688
CTCF HelaGSE12889 11462103 11462291 188 2682
CTCF G2GSE9613 11460420 11460769 349 1079
CTCF G2GSE9613 11461913 11462640 727 2761
CTCF G2GSE9613 11466529 11466959 430 7229
CTCF G2GSE9613 11467541 11467808 267 8159
CTCF G2GSE9613 11469864 11470138 274 10486
CTCF G2GSE9613 11472402 11472738 336 13055
ER Breast-CancerGSE22609 11470418 11470998 580 11193
ER MCF7GSE19013 11467252 11467807 555 8014
ER MCF7GSE19013 11470225 11470973 748 11084
Myc K562GSE19551 11459395 11459868 473 116
NRSF pAbJurkat 11461913 11462640 727 2761
RARG MCF7GSE15244 11466215 11466959 744 7072
TFAP2C MCF7GSE21234 11466044 11468320 2276 7667
hScc1 BcellGSE12603 11461913 11462463 550 2673
hScc1 BcellGSE12603 11466571 11466959 388 7250
hScc1 BcellGSE12603 11469831 11470174 343 10487
hScc1 CdLSGSE12603 11461913 11462427 514 2655
hScc1 G2GSE9613 11461913 11462393 480 2638
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP JurkatGSE17954 11452418 11454739 2321 0
CBP T30-glioblastomaGSE21026 11394038 11394795 757 0
CTCF CD4GSE12889 11448697 11449046 349 0
CTCF CD4SISSRdata 11448697 11449046 349 0
CTCF HelaGSE12889 11448727 11449066 339 0
CTCF G2GSE9613 11402078 11403411 1333 0
CTCF G2GSE9613 11411933 11412528 595 0
CTCF G2GSE9613 11438178 11438498 320 0
CTCF G2GSE9613 11440638 11441034 396 0
CTCF G2GSE9613 11442284 11442895 611 0
CTCF G2GSE9613 11443585 11444237 652 0
CTCF G2GSE9613 11448449 11449065 616 0
CTCF G2GSE9613 11452515 11452958 443 0
CTCF G2GSE9613 11457585 11457868 283 0
CTCF G2GSE9613 11458188 11459858 1670 0
ER Fulvestrant-MCF7GSE14664 11448468 11448502 34 0
FOXA1 DLD1GSE12801 11405749 11406129 380 0
FOXA1 MCF7GSE15244 11448674 11449027 353 0
NFkBII GM10847GSE19485 11402609 11403859 1250 0
NFkBII GM12878GSE19485 11402519 11403841 1322 0
NFkBII GM12878GSE19485 11440143 11441750 1607 0
NFkBII GM15510GSE19485 11440097 11441440 1343 0
Oct1 H2O2-HelaGSE14283 11393705 11393744 39 0
Oct1 HelaGSE14283 11397050 11397084 34 0
Oct1 HelaGSE14283 11431840 11431875 35 0
Oct1 HelaGSE14283 11436413 11436444 31 0
Oct1 HelaGSE14283 11448465 11448502 37 0
P300 T30-glioblastomaGSE21026 11404857 11406403 1546 0
hScc1 BcellGSE12603 11403229 11403522 293 0
hScc1 BcellGSE12603 11432277 11433332 1055 0
hScc1 BcellGSE12603 11448206 11449454 1248 0
hScc1 BcellGSE12603 11453281 11454168 887 0
hScc1 BcellGSE12603 11457585 11458376 791 0
hScc1 BcellGSE12603 11458818 11459858 1040 0
hScc1 CdLSGSE12603 11393670 11393957 287 0
hScc1 CdLSGSE12603 11432135 11433038 903 0
hScc1 CdLSGSE12603 11448263 11449353 1090 0
hScc1 CdLSGSE12603 11459082 11459858 776 0
hScc1 G2GSE9613 11442062 11442628 566 0
hScc1 G2GSE9613 11457795 11459858 2063 0
Validated miRNA targets Top
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
25072 mRNA BLK chr8 11388929 11459516 828 mRNA chr8 11456758 11459612Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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