AutismKB 2.0

Annotation Detail for MAP2K4


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Basic Information Top
Gene Symbol:MAP2K4 ( JNKK,JNKK1,MAPKK4,MEK4,MKK4,PRKMK4,SEK1,SERK1 )
Gene Full Name: mitogen-activated protein kinase kinase 4
Band: 17p12
Quick LinksEntrez ID:6416; OMIM: 601335; Uniprot ID:MP2K4_HUMAN; ENSEMBL ID: ENSG00000065559; HGNC ID: 6844
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
2N-acetylalanine.
18Phosphoserine.
26Phosphoserine.
80Phosphoserine.
90Phosphoserine.
257Phosphoserine.
391Phosphothreonine.
394Phosphoserine.
Location(AA) Modifications Resource
80Phosphoserine (PKB
257Phosphoserine (MAP2K4)Phospho.ELM 6.0
261Phosphothreonine (MAP2K4;MAP3K)Phospho.ELM 6.0
Location(AA) Modification Resource
12O-linkedHMM predict
16O-linkedHMM predict
16Phosphoserine(IKK)HMM predict
18O-linkedHMM predict
20Phosphothreonine(MAPK)HMM predict
26Phosphoserine(CDC2)HMM predict
26O-linkedHMM predict
35O-linkedHMM predict
64N-linkedHMM predict
70N-linkedHMM predict
80Phosphoserine(CK1)HMM predict
80Phosphoserine(IKK)HMM predict
80Phosphoserine(CAMK2)HMM predict
113Phosphotyrosine(INSR)HMM predict
135Phosphoserine(PKB)HMM predict
191Phosphotyrosine(Jak)HMM predict
193Phosphotyrosine(Jak)HMM predict
194Phosphoserine(Jak)HMM predict
284Phosphotyrosine(Syk)HMM predict
331Phosphoserine(CK1)HMM predict
391Phosphothreonine(MAPK)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_003010
  • Location:chr17 11864859-11987774
  • strand:+
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Oct1 HelaGSE14283 12005600 12005638 38 17845
RNAII Tamoxifen-MCF7GSE14664 12005571 12005632 61 17827
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 11864789 11865434 645 0
ER E2-MCF7GSE14664 11870856 11870892 36 0
ERG prostate-cancerGSE14092 11886417 11886982 565 0
Fos K562GSE19551 11933854 11934374 520 0
H3K4me3 colorectalcancer 11865843 11866259 416 0
KLF4 hESGSE17917 11940101 11940256 155 0
Nanog hESGSE18292 11890683 11891276 593 0
Oct1 HelaGSE14283 11947096 11947125 29 0
Oct1 HelaGSE14283 11976907 11976984 77 0
Oct1 HelaGSE14283 11978143 11978173 30 0
Oct4 hESGSE17917 11940098 11940247 149 0
PHF8 293TGSE20725 11864507 11865544 1037 0
PHF8 HeLaGSE20725 11864453 11865765 1312 0
PHF8 Hs68plusFBSGSE20725 11864457 11866144 1687 0
TAF k562GSE8489 11865670 11866508 838 0
hScc1 BcellGSE12603 11864746 11865562 816 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-141 hsa-mir-141 12 19861690
hsa-miR-141* hsa-mir-141 12 19861690
hsa-miR-15b hsa-mir-15b 3 19861690
hsa-miR-15b* hsa-mir-15b 3 19861690
hsa-miR-16 hsa-mir-16-1 13 17683260
hsa-miR-16 hsa-mir-16-2 3 17683260
hsa-miR-24 hsa-mir-24-1 9 19861690
hsa-miR-24 hsa-mir-24-2 19 19861690
hsa-miR-25 hsa-mir-25 7 19861690
hsa-miR-25* hsa-mir-25 7 19861690
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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