Annotation Detail for SFTPC

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Basic Information Top

Gene Symbol:	SFTPC ( PSP-C,SFTP2,SMDP2,SP-C )
Gene Full Name:	surfactant protein C
Band:	8p21.3
Quick Links	Entrez ID:6440; OMIM: 178620; Uniprot ID:PSPC_HUMAN; ENSEMBL ID: ENSG00000168484; HGNC ID: 10802
Relate to Another Database:	SFARIGene; denovo-db

Pathways, Diseases and Drugs

TF binding site

Post Translation Modification

PTM Sites from Uniprot:1 results
Experimental PTM Sites from dbPTM:2 results
Predicted PTM Sites by profile HMM from dbPTM:10 results

Location(AA)	Modification
16	Phosphotyrosine.

Location(AA)	Modification	Resource
16	Phosphotyrosine(SRC)	HMM predict
21	Methylarginine	HMM predict
28	S-palmitoyl	HMM predict
29	S-palmitoyl	HMM predict
61	Phosphoserine(ATM)	HMM predict
91	O-linked	HMM predict
95	O-linked	HMM predict
133	Phosphoserine(CK1)	HMM predict
159	Phosphoserine(IKK)	HMM predict
183	Methionine	HMM predict

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

RefSeq ID: NM_003018
Location:chr8 22075112-22077927
strand:+

Upstream the gene:4 results
Downstream the gene:3 results
Inside the gene:4 results

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CTCF	G2	GSE9613	22073029	22073345	316	1926
H3K27me3	colorectal	cancer	22074203	22074896	693	563
TFAP2C	MCF7	GSE21234	22072793	22073534	741	1949
TFAP2C	MCF7	GSE21234	22074844	22075346	502	18

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CTCF	G2	GSE9613	22077894	22078115	221	77
hScc1	Bcell	GSE12603	22077931	22078115	184	96
hScc1	G2	GSE9613	22077823	22078115	292	42

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CTCF	G2	GSE9613	22076155	22076410	255	0
CTCF	G2	GSE9613	22076660	22077400	740	0
NRSF	pAb	Jurkat	22076155	22077026	871	0
hScc1	CdLS	GSE12603	22077713	22078115	402	0

Validated miRNA targets

miR Walk:6 results
Tarbase V5.0:0 results

Micro RNA Name	Stem Loop Name	The chromosome that miRNA located	Publication
hsa-let-7d	hsa-let-7d	9	20395557
hsa-let-7d*	hsa-let-7d	9	20395557
hsa-miR-17	hsa-mir-17	13	17765889
hsa-miR-17*	hsa-mir-17	13	17765889
hsa-miR-92a	hsa-mir-92a-1	13	17765889
hsa-miR-92a	hsa-mir-92a-2	X	17765889

Cis-Nats regulation

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

Studies: 1,036
Genes: 1,379
CNVs/SVs: 5,420
SNVs/Indels: 11,669
de novo Mutations: 5,669
Mosaics: 789
Linkage Regions: 172

Paper Collected: 6/30/2018

Last Update: 8/26/2018

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