AutismKB 2.0

Annotation Detail for KLHL25


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Basic Information Top
Gene Symbol:KLHL25 ( ENC-2,ENC2,FLJ12587,FLJ45015 )
Gene Full Name: kelch-like 25 (Drosophila)
Band: 15q25.3
Quick LinksEntrez ID:64410; OMIM: NA; Uniprot ID:ENC2_HUMAN; ENSEMBL ID: ENSG00000183655; HGNC ID: 25732
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
No data
No data
Location(AA) Modification Resource
13Phosphoserine(IKK)HMM predict
19N-linkedHMM predict
119Phosphoserine(CK1)HMM predict
287S-palmitoylHMM predict
328Phosphoserine(MAPK)HMM predict
328Phosphoserine(CDC2)HMM predict
406Phosphoserine(MAPK)HMM predict
406Phosphoserine(CDC2)HMM predict
549Phosphothreonine(PKC)HMM predict
554Phosphothreonine(PKC)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_022480
  • Location:chr15 84103564-84139192
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Oct1 H2O2-HelaGSE14283 84152010 84152040 30 12833
Oct1 HelaGSE14283 84152004 84152040 36 12830
P300 T30-glioblastomaGSE21026 84144598 84145346 748 5780
Rb QuiescentGSE19898 84139388 84139527 139 265
Rb SenescentGSE19898 84139365 84139619 254 300
TFAP2C MCF7GSE21234 84144599 84145113 514 5664
p130 shRbSenescentGSE19898 84139394 84139576 182 293
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 84100084 84100383 299 3331
CTCF G2GSE9613 84102447 84102667 220 1008
hScc1 BcellGSE12603 84102447 84103039 592 822
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 84104631 84105297 666 0
CTCF G2GSE9613 84107512 84108183 671 0
CTCF G2GSE9613 84109214 84109408 194 0
CTCF G2GSE9613 84119931 84120074 143 0
CTCF G2GSE9613 84121401 84121710 309 0
CTCF G2GSE9613 84129917 84130101 184 0
CTCF G2GSE9613 84138638 84139241 603 0
Fos K562GSE19551 84138860 84139485 625 0
H3ac HepG2E 84136722 84138480 1758 0
NFkBII GM10847GSE19485 84138369 84139781 1412 0
Oct1 HelaGSE14283 84119663 84119699 36 0
Rb SenescentGSE19898 84139036 84139290 254 0
Rb shRbSenescenceGSE19898 84139079 84139224 145 0
hScc1 BcellGSE12603 84105225 84105409 184 0
hScc1 BcellGSE12603 84107077 84107593 516 0
hScc1 BcellGSE12603 84119897 84120074 177 0
hScc1 BcellGSE12603 84138638 84139241 603 0
p130 SenescentGSE19898 84138974 84139308 334 0
p130 shRbSenescentGSE19898 84139072 84139297 225 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018