AutismKB 2.0

Annotation Detail for SGK1


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Basic Information Top
Gene Symbol:SGK1 ( SGK )
Gene Full Name: serum/glucocorticoid regulated kinase 1
Band: 6q23.2
Quick LinksEntrez ID:6446; OMIM: 602958; Uniprot ID:SGK1_HUMAN; ENSEMBL ID: ENSG00000118515; HGNC ID: 10810
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
74Phosphoserine.
78Phosphoserine.
141Nuclear localization signal.
256Phosphothreonine; by PDPK1.
397Phosphoserine.
401Phosphoserine.
422Phosphoserine.
Location(AA) Modifications Resource
78Phosphoserine (MAPK7)Phospho.ELM 6.0
256Phosphothreonine (by PDPK1).Swiss-Prot 53.0
256Phosphothreonine (PDK-2;PDK-1)Phospho.ELM 6.0
369Phosphothreonine (PKA
377Phosphoserine (NEK6)Phospho.ELM 6.0
422Phosphoserine.Swiss-Prot 53.0
422Phosphoserine (NEK6;PDK-2;P)Phospho.ELM 6.0
Location(AA) Modification Resource
61Phosphoserine(ATM)HMM predict
72N-linkedHMM predict
74O-linkedHMM predict
78PhosphoserineHMM predict
78Phosphoserine(CDK)HMM predict
78Phosphoserine(CDC2)HMM predict
80Phosphoserine(ATM)HMM predict
212Phosphotyrosine(Jak)HMM predict
232Phosphoserine(ATM)HMM predict
251N-linkedHMM predict
254O-linkedHMM predict
255O-linkedHMM predict
256O-linkedHMM predict
256PhosphothreonineHMM predict
319N-linkedHMM predict
322N-linkedHMM predict
375N-linkedHMM predict
380N-linkedHMM predict
401Phosphoserine(CDC2)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_005627
  • Location:chr6 134532081-134537694
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 134539025 134539294 269 1465
Gata2 K562GSE18868 134537349 134538327 978 144
H3K4me3 colorectalcancer 134540087 134540276 189 2487
H3ac HepG2E 134538679 134538992 313 1141
Nanog hESGSE18292 134555100 134555407 307 17559
Oct1 H2O2-HelaGSE14283 134554675 134554701 26 16994
Oct1 HelaGSE14283 134554665 134554706 41 16991
PHF8 Hs68minusFBSGSE20725 134537378 134539028 1650 509
PHF8 Hs68plusFBSGSE20725 134536681 134538920 2239 106
Pol2 GM12878GSE19551 134537391 134538015 624 9
PolII HeLaGSE12783 134539994 134542054 2060 3330
TAF HelaGSE8489 134540087 134541030 943 2864
TFAP2C MCF7GSE21234 134538712 134539219 507 1271
hScc1 BcellGSE12603 134541180 134541730 550 3761
hScc1 CdLSGSE12603 134540904 134541886 982 3701
p130 shRbQuiescentGSE19898 134540831 134541396 565 3419
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 134519664 134519960 296 12270
CTCF CD4SISSRdata 134519664 134519960 296 12270
CTCF G2GSE9613 134519578 134520018 440 12284
Oct1 H2O2-HelaGSE14283 134522549 134522576 27 9519
Oct1 HelaGSE14283 134522550 134522577 27 9518
Sox2 hESGSE18292 134519683 134520159 476 12161
hScc1 BcellGSE12603 134519553 134520045 492 12283
hScc1 CdLSGSE12603 134519382 134520108 726 12337
hScc1 G2GSE9613 134519553 134520108 555 12251
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 134536716 134537046 330 0
CTCF CD4SISSRdata 134536716 134537046 330 0
CTCF G2GSE9613 134536668 134538370 1702 0
H3K4me3 colorectalcancer 134535789 134536244 455 0
H3ac HepG2E 134537107 134537588 481 0
PolII HeLaGSE12783 134527650 134539854 12204 0
TAF HelaGSE8489 134535513 134537651 2138 0
TAF k562GSE8489 134537144 134537651 507 0
hScc1 BcellGSE12603 134536591 134538443 1852 0
hScc1 CdLSGSE12603 134536591 134537798 1207 0
p130 SenescentGSE19898 134537392 134537722 330 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-133a hsa-mir-133a-1 18 20013939
hsa-miR-133a hsa-mir-133a-2 20 20013939
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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