AutismKB 2.0

Annotation Detail for SHB


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:SHB ( RP11-3J10.8,bA3J10.2 )
Gene Full Name: Src homology 2 domain containing adaptor protein B
Band: 9p13.1
Quick LinksEntrez ID:6461; OMIM: 600314; Uniprot ID:SHB_HUMAN; ENSEMBL ID: ENSG00000107338; HGNC ID: 10838
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
114Phosphotyrosine.
156Phosphoserine (By similarity).
246Phosphotyrosine.
268Phosphotyrosine.
310Phosphoserine.
314Phosphoserine.
317Phosphoserine.
336Phosphotyrosine.
388Phosphoserine.
Location(AA) Modifications Resource
114Phosphotyrosine (By similarity).Swiss-Prot 53.0
156Phosphoserine (By similarity).Swiss-Prot 53.0
246Phosphotyrosine.Swiss-Prot 53.0
246PhosphotyrosinePhospho.ELM 6.0
Location(AA) Modification Resource
18Phosphoserine(CDC2)HMM predict
18Phosphoserine(IKK)HMM predict
18Phosphoserine(PKA)HMM predict
33MethylarginineHMM predict
38Phosphoserine(ATM)HMM predict
48O-linkedHMM predict
48O-linkedHMM predict
49O-linkedHMM predict
52O-linkedHMM predict
64Phosphoserine(CK1)HMM predict
69Phosphoserine(IKK)HMM predict
69Phosphoserine(CK1)HMM predict
76Phosphoserine(CK1)HMM predict
96Phosphotyrosine(Syk)HMM predict
101Phosphoserine(CDC2)HMM predict
134O-linkedHMM predict
140S-palmitoylHMM predict
141S-palmitoylHMM predict
151O-linkedHMM predict
153O-linkedHMM predict
154Phosphoserine(CK1)HMM predict
154O-linkedHMM predict
155O-linkedHMM predict
155O-linkedHMM predict
156O-linkedHMM predict
156Phosphoserine(ATM)HMM predict
156O-linkedHMM predict
172Phosphothreonine(PKA)HMM predict
172Phosphothreonine(MAPK)HMM predict
211Phosphoserine(IKK)HMM predict
268PhosphotyrosineHMM predict
268Phosphotyrosine(INSR)HMM predict
268Phosphotyrosine(Syk)HMM predict
272Phosphotyrosine(Syk)HMM predict
286Phosphoserine(PKB)HMM predict
286Phosphoserine(PKA)HMM predict
301Phosphotyrosine(Syk)HMM predict
310Phosphoserine(CK2)HMM predict
310Phosphoserine(CK1)HMM predict
312Phosphoserine(CK1)HMM predict
314Phosphoserine(CK1)HMM predict
314Phosphoserine(IKK)HMM predict
317Phosphoserine(CDK)HMM predict
323Phosphoserine(PKG)HMM predict
362Phosphoserine(IKK)HMM predict
362PhosphoserineHMM predict
363Phosphoserine(PKB)HMM predict
363Phosphoserine(IKK)HMM predict
365Phosphoserine(CDC2)HMM predict
437Phosphoserine(PKG)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_003028
  • Location:chr9 37905895-38059209
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 38077921 38078281 360 18892
CTCF CD4SISSRdata 38077921 38078281 360 18892
CTCF HelaGSE12889 38077947 38078250 303 18889
Fos K562GSE19551 38059581 38060138 557 650
Fos K562GSE19551 38069380 38069801 421 10381
Myc K562GSE19551 38078067 38078378 311 19013
Nanog hESGSE18292 38074410 38074767 357 15379
P300 T0-glioblastomaGSE21026 38073575 38074334 759 14745
PHF8 293TGSE20725 38058574 38060304 1730 230
RARA MCF7GSE15244 38059622 38060000 378 602
TFAP2C MCF7GSE21234 38059367 38060150 783 549
hScc1 BcellGSE12603 38077816 38078493 677 18945
hScc1 CdLSGSE12603 38077670 38078741 1071 18996
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 37903654 37903969 315 2084
CTCF CD4SISSRdata 37903654 37903969 315 2084
CTCF JurkatGSE12889 37903546 37903945 399 2150
hScc1 BcellGSE12603 37903340 37904365 1025 2043
hScc1 BcellGSE12603 37904951 37905297 346 772
hScc1 CdLSGSE12603 37903340 37904245 905 2103
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T30-glioblastomaGSE21026 37943482 37944648 1166 0
ER MCF7GSE19013 37943435 37944370 935 0
ER MCF7GSE19013 38012632 38013698 1066 0
ER MCF7GSE19013 38014115 38014740 625 0
ER MCF7GSE19013 38051384 38051871 487 0
ETS1 JurkatGSE17954 37910318 37910791 473 0
FOXA1 MCF7GSE15244 37954236 37955023 787 0
FOXA1 MCF7GSE15244 38036429 38038124 1695 0
Fos K562GSE19551 37943502 37944314 812 0
Gata1 K562GSE18868 37926882 37927360 478 0
H3ac HepG2E 38055113 38056608 1495 0
Myc K562GSE19551 37926826 37927420 594 0
Nanog hESGSE18292 38052885 38053088 203 0
Oct1 H2O2-HelaGSE14283 37975836 37975871 35 0
Oct1 HelaGSE14283 37975836 37975871 35 0
P300 T30-glioblastomaGSE21026 37927766 37928801 1035 0
PHF8 HeLaGSE20725 38057463 38059925 2462 0
RARA MCF7GSE15244 37933275 37934553 1278 0
RARA MCF7GSE15244 37942134 37944898 2764 0
RARA MCF7GSE15244 38036429 38038058 1629 0
Rb SenescentGSE19898 37954155 37954368 213 0
Rb shRbSenescenceGSE19898 37954139 37954466 327 0
TFAP2C MCF7GSE21234 37934799 37935528 729 0
TFAP2C MCF7GSE21234 37943583 37944597 1014 0
TFAP2C MCF7GSE21234 37953812 37954765 953 0
TFAP2C MCF7GSE21234 38012757 38013537 780 0
TFAP2C MCF7GSE21234 38013647 38014684 1037 0
TFAP2C MCF7GSE21234 38017560 38018119 559 0
hScc1 BcellGSE12603 37910623 37910838 215 0
hScc1 BcellGSE12603 37947091 37947421 330 0
hScc1 BcellGSE12603 37985240 37985518 278 0
hScc1 BcellGSE12603 38057806 38059109 1303 0
p130 SenescentGSE19898 37927874 37928352 478 0
p130 SenescentGSE19898 37956668 37956875 207 0
p63 keratinocytesGSE17611 38013651 38014839 1188 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved