AutismKB 2.0

Annotation Detail for AEN


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Basic Information Top
Gene Symbol:AEN ( FLJ12484,FLJ12562,ISG20L1,pp12744 )
Gene Full Name: apoptosis enhancing nuclease
Band: 15q26.1
Quick LinksEntrez ID:64782; OMIM: 610177; Uniprot ID:AEN_HUMAN; ENSEMBL ID: ENSG00000181026; HGNC ID: 25722
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
35Nucleolar localization signal.
188Nuclear localization signal.
Location(AA) Modifications Resource
No data
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_022767
  • Location:chr15 86965592-86976515
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 86958877 86959044 167 6632
CTCF CD4SISSRdata 86958877 86959044 167 6632
CTCF JurkatGSE12889 86958875 86959158 283 6576
CTCF G2GSE9613 86948407 86948650 243 17064
CTCF G2GSE9613 86949758 86949923 165 15752
CTCF G2GSE9613 86958749 86958937 188 6750
E2F4 G0GSE7516 86964949 86965785 836 226
Fos K562GSE19551 86965112 86965774 662 150
H3ac HepG2E 86964949 86965347 398 445
LIN9 SGSE7516 86964949 86966069 1120 84
Myc K562GSE19551 86958645 86959169 524 6686
Myc hESGSE17917 86965327 86965794 467 32
NFkBII GM12878GSE19485 86959350 86960805 1455 5515
NFkBII GM12892GSE19485 86959657 86960868 1211 5330
NRSF JurkatGSE13047 86949378 86950564 1186 15622
NRSF mAbJurkat 86949961 86953585 3624 13820
NRSF-mono JurkatQuESTdata 86949340 86950434 1094 15706
NRSF-poly JurkatQuESTdata 86949745 86950509 764 15466
Oct1 HelaGSE14283 86949098 86949149 51 16469
hScc1 BcellGSE12603 86948258 86948686 428 17121
hScc1 BcellGSE12603 86958749 86958937 188 6750
hScc1 G2GSE9613 86958749 86958937 188 6750
p130 QuiescentGSE19898 86964922 86965636 714 314
p130 SenescentGSE19898 86964793 86965685 892 354
p130 shRbQuiescentGSE19898 86964984 86965805 821 198
p130 SGSE7516 86964949 86965785 836 226
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 86968571 86968866 295 0
CTCF CD4SISSRdata 86968571 86968866 295 0
CTCF G2GSE9613 86965458 86965785 327 0
CTCF G2GSE9613 86970535 86970892 357 0
CTCF G2GSE9613 86974361 86974703 342 0
H3K4me3 colorectalcancer 86965973 86966588 615 0
H3ac HepG2E 86965898 86966588 690 0
H3ac HepG2E 86967175 86968661 1486 0
LIN9 G0GSE7516 86964949 86966588 1639 0
hScc1 BcellGSE12603 86968383 86968661 278 0
hScc1 BcellGSE12603 86970362 86970641 279 0
p130 shRbSenescentGSE19898 86964919 86966419 1500 0
p130 G0GSE7516 86964949 86966588 1639 0
p63 keratinocytesGSE17611 86965180 86966241 1061 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018