Annotation Detail for USP46

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Basic Information Top

Gene Symbol:	USP46 ( FLJ11850,FLJ12552,FLJ14283,FLJ39393 )
Gene Full Name:	ubiquitin specific peptidase 46
Band:	4q12
Quick Links	Entrez ID:64854; OMIM: 612849; Uniprot ID:UBP46_HUMAN; ENSEMBL ID: ENSG00000109189; HGNC ID: 20075
Relate to Another Database:	SFARIGene; denovo-db

Pathways, Diseases and Drugs

TF binding site

Post Translation Modification

PTM Sites from Uniprot:0 results
Experimental PTM Sites from dbPTM:0 results
Predicted PTM Sites by profile HMM from dbPTM:10 results

No data

Location(AA)	Modification	Resource
89	Phosphothreonine(PKC)	HMM predict
116	Phosphotyrosine(Syk)	HMM predict
116	Sulfotyrosine	HMM predict
178	N-linked	HMM predict
184	N-linked	HMM predict
190	Phosphoserine(CK2)	HMM predict
205	N-linked	HMM predict
284	N-linked	HMM predict
314	Phosphotyrosine(INSR)	HMM predict
358	Phosphotyrosine(INSR)	HMM predict

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

RefSeq ID: NM_022832
Location:chr4 53155966-53220196
strand:-

Upstream the gene:7 results
Downstream the gene:6 results
Inside the gene:17 results

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CTCF	G2	GSE9613	53219966	53220763	797	168
CTCF	G2	GSE9613	53231636	53231790	154	11517
H3K4me3	colorectal	cancer	53220803	53221429	626	920
PHF8	HeLa	GSE20725	53219615	53221181	1566	202
hScc1	Bcell	GSE12603	53220418	53220997	579	511
hScc1	Bcell	GSE12603	53226448	53226762	314	6409
hScc1	CdLS	GSE12603	53226448	53226762	314	6409

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CTCF	CD4	GSE12889	53149135	53149259	124	6770
CTCF	CD4	SISSRdata	53149135	53149259	124	6770
CTCF	G2	GSE9613	53148793	53149438	645	6851
ER	E2-MCF7	GSE14664	53151297	53151333	36	4652
hScc1	Bcell	GSE12603	53149034	53149290	256	6805
hScc1	CdLS	GSE12603	53148793	53149438	645	6851

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CBP	T0-glioblastoma	GSE21026	53170660	53170871	211	0
CBP	T30-glioblastoma	GSE21026	53170384	53170873	489	0
CTCF	G2	GSE9613	53198656	53198912	256	0
CTCF	G2	GSE9613	53218034	53218433	399	0
CTCF	G2	GSE9613	53219112	53219359	247	0
ER	Fulvestrant-MCF7	GSE14664	53169115	53169156	41	0
Fos	K562	GSE19551	53202912	53203157	245	0
Nanog	hES	GSE18292	53218540	53219206	666	0
Oct1	H2O2-Hela	GSE14283	53158152	53158204	52	0
Oct1	Hela	GSE14283	53158152	53158204	52	0
Oct1	Hela	GSE14283	53169118	53169154	36	0
PHF8	293T	GSE20725	53219586	53220789	1203	0
PHF8	Hs68plusFBS	GSE20725	53219144	53221175	2031	0
RNAII	Tamoxifen-MCF7	GSE14664	53169113	53169157	44	0
RNAII	Tamoxifen-MCF7	GSE14664	53176024	53176102	78	0
hScc1	Bcell	GSE12603	53198553	53198912	359	0
hScc1	Bcell	GSE12603	53219083	53219532	449	0

Validated miRNA targets

Cis-Nats regulation

Cluster ID	Plue Type	Plus Gene Name	Plus Chromosome	Plus Start	Plus End	Overlap Length	Minus Type	Minus Gene Name	Minus Chromosome	Minus Star	Minus End	Type
19667	EST		chr4	53363758	53368396	2610	mRNA	USP46	chr4	53302137	53366368	Non-exonic Bidirectional (NOB) pairs

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

Studies: 1,036
Genes: 1,379
CNVs/SVs: 5,420
SNVs/Indels: 11,669
de novo Mutations: 5,669
Mosaics: 789
Linkage Regions: 172

Paper Collected: 6/30/2018

Last Update: 8/26/2018

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