AutismKB 2.0

Annotation Detail for PLEKHG2


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Basic Information Top
Gene Symbol:PLEKHG2 ( ARHGEF42,CLG,DKFZp667J2325,FLJ00018,FLJ22458,FLJ38638 )
Gene Full Name: pleckstrin homology domain containing, family G (with RhoGef domain) member 2
Band: 19q13.2
Quick LinksEntrez ID:64857; OMIM: 611893; Uniprot ID:PKHG2_HUMAN; ENSEMBL ID: ENSG00000090924; HGNC ID: 29515
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
445Phosphothreonine.
450Phosphoserine.
610Phosphoserine.
1257Phosphothreonine.
1261Phosphoserine.
Location(AA) Modifications Resource
No data
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_022835
  • Location:chr19 44595589-44607993
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 44593707 44594611 904 1431
CTCF G2GSE9613 44594971 44595586 615 311
Fos K562GSE19551 44594194 44595262 1068 862
PHF8 293TGSE20725 44594928 44595701 773 275
Rb GrowingGSE19898 44594977 44595119 142 542
Rb QuiescentGSE19898 44594596 44595228 632 678
Rb SenescentGSE19898 44594925 44595462 537 396
USF1 HepG2E 44593467 44594757 1290 1478
USF2 HepG2E 44593245 44594757 1512 1589
hScc1 BcellGSE12603 44593428 44594757 1329 1497
hScc1 BcellGSE12603 44595046 44595661 615 236
hScc1 CdLSGSE12603 44593533 44595973 2440 837
hScc1 G2GSE9613 44593850 44594757 907 1286
p130 QuiescentGSE19898 44594671 44595169 498 670
p130 SenescentGSE19898 44594078 44595142 1064 980
p130 shRbSenescentGSE19898 44594885 44595305 420 495
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Oct1 HelaGSE14283 44610194 44610233 39 2220
Oct1 HelaGSE14283 44611370 44611424 54 3404
Rb GrowingGSE19898 44611205 44611400 195 3309
p130 QuiescentGSE19898 44611144 44611359 215 3258
p130 SenescentGSE19898 44610756 44611173 417 2971
p130 shRbQuiescentGSE19898 44610766 44611433 667 3106
p130 shRbSenescentGSE19898 44611143 44611408 265 3282
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP JurkatGSE17954 44593852 44597567 3715 0
CTCF G2GSE9613 44596622 44597097 475 0
p130 shRbQuiescentGSE19898 44596325 44597154 829 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-1 hsa-mir-1-2 18 15685193
hsa-miR-1 hsa-mir-1-1 20 15685193
hsa-miR-124 hsa-mir-124-1 8 15685193
hsa-miR-124 hsa-mir-124-2 8 15685193
hsa-miR-124 hsa-mir-124-3 20 15685193
hsa-miR-373 hsa-mir-373 19 15685193
hsa-miR-373* hsa-mir-373 19 15685193
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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