AutismKB 2.0

Annotation Detail for SLC1A2


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Basic Information Top
Gene Symbol:SLC1A2 ( EAAT2,GLT-1 )
Gene Full Name: solute carrier family 1 (glial high affinity glutamate transporter), member 2
Band: 11p13
Quick LinksEntrez ID:6506; OMIM: 600300; Uniprot ID:EAA2_HUMAN; ENSEMBL ID: ENSG00000110436; HGNC ID: 10940
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
21Phosphoserine.
206N-linked (GlcNAc...) (Potential).
216N-linked (GlcNAc...) (Potential).
494Phosphotyrosine (By similarity).
539Phosphotyrosine (By similarity).
564Phosphoserine (By similarity).
Location(AA) Modifications Resource
21Phosphoserine.Swiss-Prot 53.0
21PhosphoserinePhospho.ELM 6.0
206N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
216N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
564Phosphoserine (By similarity).Swiss-Prot 53.0
Location(AA) Modification Resource
118Phosphothreonine(PKA)HMM predict
190Phosphothreonine(PKC)HMM predict
206N-linkedHMM predict
216N-linkedHMM predict
363O-linkedHMM predict
363O-linkedHMM predict
429Phosphoserine(IKK)HMM predict
441O-linkedHMM predict
480Phosphoserine(PKG)HMM predict
523Phosphotyrosine(INSR)HMM predict
523Phosphotyrosine(Syk)HMM predict
564PhosphoserineHMM predict
564Phosphoserine(ATM)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_004171
  • Location:chr11 35229328-35397680
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
H3K27me3 colorectalcancer 35397724 35398744 1020 554
H3K27me3 colorectalcancer 35399144 35401385 2241 2584
Oct1 H2O2-HelaGSE14283 35402263 35402310 47 4606
Oct1 HelaGSE14283 35402244 35402310 66 4597
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
FOXA1 DLD1GSE12801 35220410 35221111 701 8568
RARA MCF7GSE15244 35226472 35227017 545 2584
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 35283898 35284248 350 0
CTCF CD4GSE12889 35370362 35370694 332 0
CTCF CD4SISSRdata 35283898 35284248 350 0
CTCF CD4SISSRdata 35370362 35370694 332 0
CTCF JurkatGSE12889 35370404 35370627 223 0
ER MCF7GSE19013 35242309 35242889 580 0
ER MCF7GSE19013 35368879 35369924 1045 0
FOXA1 DLD1GSE12801 35297448 35298257 809 0
FOXA1 DLD1GSE12801 35368096 35368293 197 0
FOXA1 DLD1GSE12801 35369617 35369896 279 0
FOXA1 MCF7GSE15244 35253316 35254220 904 0
FOXA1 MCF7GSE15244 35273930 35274373 443 0
FOXA1 MCF7GSE15244 35368096 35368293 197 0
FOXA1 MCF7GSE15244 35369617 35370156 539 0
FOXA1 MCF7GSE15244 35381504 35382936 1432 0
FoxA1 MCF7MACSdata 35343987 35344351 364 0
FoxA1 MCF7MACSdata 35368039 35368443 404 0
FoxA1 MCF7MACSdata 35369057 35369521 464 0
GATA3 MCF7GSE15244 35273930 35275150 1220 0
H3K27me3 colorectalcancer 35394960 35397046 2086 0
Myc K562GSE19551 35382690 35383000 310 0
NRSF-mono JurkatQuESTdata 35240903 35241276 373 0
NRSF pAbJurkat 35353550 35353873 323 0
NRSF-poly JurkatQuESTdata 35240864 35241186 322 0
Oct1 H2O2-HelaGSE14283 35327088 35327120 32 0
Oct1 H2O2-HelaGSE14283 35331869 35331897 28 0
Oct1 HelaGSE14283 35290636 35290670 34 0
Oct1 HelaGSE14283 35312002 35312034 32 0
Oct1 HelaGSE14283 35325750 35325778 28 0
Oct1 HelaGSE14283 35327087 35327121 34 0
Oct1 HelaGSE14283 35396009 35396046 37 0
Oct4 hESGSE17917 35289960 35290110 150 0
P300 T0-glioblastomaGSE21026 35341848 35342866 1018 0
P300 T30-glioblastomaGSE21026 35238190 35239562 1372 0
P300 T30-glioblastomaGSE21026 35245300 35246425 1125 0
P300 T30-glioblastomaGSE21026 35260455 35261230 775 0
P300 T30-glioblastomaGSE21026 35315152 35316057 905 0
P300 T30-glioblastomaGSE21026 35369079 35369819 740 0
RARA MCF7GSE15244 35273482 35274512 1030 0
RARA MCF7GSE15244 35368096 35368293 197 0
RARA MCF7GSE15244 35369617 35370156 539 0
RARG MCF7GSE15244 35273600 35274512 912 0
RARG MCF7GSE15244 35368096 35368293 197 0
RARG MCF7GSE15244 35369617 35370047 430 0
RARG MCF7GSE15244 35381538 35382671 1133 0
Rb GrowingGSE19898 35390464 35390658 194 0
SRF k562GSE8489 35320946 35321199 253 0
STAT1 HeLaGSE12782 35281709 35283512 1803 0
STAT1 HeLaGSE12783 35281780 35282942 1162 0
STAT1 IFNSISSRdata 35281841 35283114 1273 0
TAFII hESGSE17917 35370379 35370634 255 0
TFAP2C MCF7GSE21234 35304252 35304843 591 0
TFAP2C MCF7GSE21234 35358643 35359044 401 0
TFAP2C MCF7GSE21234 35368989 35369915 926 0
TFAP2C MCF7GSE21234 35372522 35373183 661 0
hScc1 BcellGSE12603 35283847 35284258 411 0
hScc1 BcellGSE12603 35370203 35370958 755 0
hScc1 BcellGSE12603 35382485 35382936 451 0
hScc1 BcellGSE12603 35390526 35390773 247 0
hScc1 CdLSGSE12603 35283670 35284365 695 0
hScc1 CdLSGSE12603 35369617 35370844 1227 0
hScc1 CdLSGSE12603 35382524 35382972 448 0
hScc1 CdLSGSE12603 35390451 35390844 393 0
hScc1 G2GSE9613 35283885 35284258 373 0
hScc1 G2GSE9613 35369968 35371039 1071 0
hScc1 G2GSE9613 35390291 35390990 699 0
hScc1 G2GSE9613 35397111 35397844 733 0
p130 shRbQuiescentGSE19898 35245064 35245598 534 0
p130 shRbSenescentGSE19898 35282394 35282666 272 0
p63 keratinocytesGSE17611 35254243 35255114 871 0
Validated miRNA targets Top
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
4305 EST chr11 35397179 35399125 51 mRNA SLC1A2 chr11 35229328 35397372Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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