AutismKB 2.0

Annotation Detail for SLC1A4


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Basic Information Top
Gene Symbol:SLC1A4 ( ASCT1,SATT )
Gene Full Name: solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
Band: 2p14
Quick LinksEntrez ID:6509; OMIM: 600229; Uniprot ID:SATT_HUMAN; ENSEMBL ID: ENSG00000115902; HGNC ID: 10942
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
201N-linked (GlcNAc...).
206N-linked (GlcNAc...).
506Phosphothreonine (By similarity).
507Phosphoserine.
Location(AA) Modifications Resource
201N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
206N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
506Phosphothreonine (By similarity).Swiss-Prot 53.0
507Phosphoserine (By similarity).Swiss-Prot 53.0
Location(AA) Modification Resource
8N-linkedHMM predict
10Phosphotyrosine(Syk)HMM predict
124O-linkedHMM predict
125O-linkedHMM predict
143Phosphoserine(IKK)HMM predict
147Phosphothreonine(PKC)HMM predict
158Phosphoserine(ATM)HMM predict
195Phosphotyrosine(Syk)HMM predict
201N-linkedHMM predict
204Phosphoserine(ATM)HMM predict
206N-linkedHMM predict
242Phosphoserine(CK2)HMM predict
338O-linkedHMM predict
342O-linkedHMM predict
412O-linkedHMM predict
416O-linkedHMM predict
527Phosphoserine(CK1)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_003038
  • Location:chr2 65070097-65104500
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T30-glioblastomaGSE21026 65055753 65056665 912 13889
CTCF CD4GSE12889 65059632 65059794 162 10385
CTCF CD4SISSRdata 65059632 65059794 162 10385
CTCF G2GSE9613 65068865 65070722 1857 304
ER MCF7GSE19013 65055797 65056699 902 13850
Oct1 HelaGSE14283 65055616 65055673 57 14453
P300 T30-glioblastomaGSE21026 65055562 65056881 1319 13876
PHF8 HeLaGSE20725 65068848 65070791 1943 278
RARA MCF7GSE15244 65055932 65056546 614 13859
Rb GrowingGSE19898 65069920 65070244 324 16
Rb SenescentGSE19898 65069865 65070107 242 112
TFAP2C MCF7GSE21234 65055829 65056401 572 13983
USF1 HepG2E 65056840 65057456 616 12950
hScc1 G2GSE9613 65068836 65070686 1850 337
p130 QuiescentGSE19898 65069919 65070186 267 45
p130 shRbQuiescentGSE19898 65068812 65069875 1063 754
p130 shRbSenescentGSE19898 65068788 65069253 465 1077
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP JurkatGSE17954 65111282 65113468 2186 7875
ER E2-MCF7GSE14664 65113738 65113772 34 9255
NRSF JurkatSISSRdata 65111330 65111523 193 6926
Oct1 H2O2-HelaGSE14283 65115418 65115449 31 10933
Oct1 HelaGSE14283 65113740 65113772 32 9256
P300 T30-glioblastomaGSE21026 65104719 65105620 901 669
Rb GrowingGSE19898 65114111 65114486 375 9798
hScc1 G2GSE9613 65113975 65114391 416 9683
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 65100188 65100374 186 0
Fos K562GSE19551 65087120 65087595 475 0
Gata2 K562GSE18868 65077550 65078110 560 0
Gata2 K562GSE18868 65087134 65087568 434 0
Gata2 K562GSE18868 65102213 65102891 678 0
Oct1 H2O2-HelaGSE14283 65081219 65081247 28 0
Oct1 H2O2-HelaGSE14283 65083600 65083630 30 0
Oct1 HelaGSE14283 65083597 65083642 45 0
P300 T30-glioblastomaGSE21026 65087170 65087759 589 0
TFAP2C MCF7GSE21234 65086978 65087691 713 0
hScc1 BcellGSE12603 65069756 65070650 894 0
hScc1 BcellGSE12603 65097831 65098266 435 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-let-7b hsa-let-7b 22 18668040
hsa-let-7b* hsa-let-7b 22 18668040
hsa-miR-1 hsa-mir-1-2 18 18668040
hsa-miR-1 hsa-mir-1-1 20 18668040
hsa-miR-155 hsa-mir-155 21 18668040
hsa-miR-155* hsa-mir-155 21 18668040
hsa-miR-16 hsa-mir-16-1 13 18668040
hsa-miR-16 hsa-mir-16-2 3 18668040
hsa-miR-30a hsa-mir-30a 6 18668040
hsa-miR-30a* hsa-mir-30a 6 18668040
hsa-miR-30b hsa-mir-30b 8 18668040
hsa-miR-30b* hsa-mir-30b 8 18668040
hsa-miR-30c hsa-mir-30c-2 6 18668040
hsa-miR-30c hsa-mir-30c-1 1 18668040
hsa-miR-30c-1* hsa-mir-30c-1 1 18668040
hsa-miR-30c-2* hsa-mir-30c-2 6 18668040
hsa-miR-30d hsa-mir-30d 8 18668040
hsa-miR-30d* hsa-mir-30d 8 18668040
hsa-miR-30e hsa-mir-30e 1 18668040
hsa-miR-30e* hsa-mir-30e 1 18668040
ID in Tarbase Data Type Support Type miRNA Gene Direct Support Publication
893 Unknown pSILAC let-7b SLC1A4 down 50-25% 18668040
Ensembl Protein Type Differentially expressed in Pathology or Event Mis Regulation Gene Expression Tumour Involvement
ENSG00000115902 n_a n_a n_a "epithelium, lymphocyte, leukocyte, macrophage, muscle cell" "benign tumour, malignant tumour, carcinoma, leukaemia, non-Hodgkin's, sarcoma"
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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