AutismKB 2.0

Annotation Detail for WNK3


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Basic Information Top
Gene Symbol:WNK3 ( FLJ30437,FLJ42662,KIAA1566,PRKWNK3 )
Gene Full Name: WNK lysine deficient protein kinase 3
Band: Xp11.22
Quick LinksEntrez ID:65267; OMIM: 300358; Uniprot ID:WNK3_HUMAN; ENSEMBL ID: ENSG00000196632; HGNC ID: 14543
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
304Phosphoserine; by autocatalysis (By
308Phosphoserine; by autocatalysis (By
734Phosphoserine.
1424Phosphoserine.
Location(AA) Modifications Resource
304Phosphoserine (by autocatalysis) (Bysimilarity).Swiss-Prot 53.0
308Phosphoserine (by autocatalysis) (Bysimilarity).Swiss-Prot 53.0
Location(AA) Modification Resource
10Phosphoserine(IKK)HMM predict
10PhosphoserineHMM predict
11Phosphothreonine(PKC)HMM predict
43N-linkedHMM predict
52Phosphothreonine(PKC)HMM predict
141Phosphoserine(CDC2)HMM predict
184Phosphothreonine(PKC)HMM predict
321Phosphotyrosine(EGFR)HMM predict
325SulfotyrosineHMM predict
346SulfotyrosineHMM predict
358Phosphotyrosine(EGFR)HMM predict
389N-linkedHMM predict
458Phosphothreonine(CDC2)HMM predict
464Phosphotyrosine(SRC)HMM predict
464Phosphotyrosine(Abl)HMM predict
464Phosphotyrosine(Syk)HMM predict
509Phosphoserine(PKG)HMM predict
509Phosphoserine(IKK)HMM predict
513Phosphoserine(IKK)HMM predict
523N-linkedHMM predict
524O-linkedHMM predict
562Phosphoserine(CK1)HMM predict
583Phosphoserine(CK1)HMM predict
583Phosphoserine(ATM)HMM predict
583Phosphoserine(IKK)HMM predict
592N-linkedHMM predict
617Phosphoserine(CDK)HMM predict
663O-linkedHMM predict
682Phosphoserine(ATM)HMM predict
708Phosphothreonine(CK2)HMM predict
712N-linkedHMM predict
714O-linkedHMM predict
715Phosphoserine(CDC2)HMM predict
718N-linkedHMM predict
722N-linkedHMM predict
734Phosphoserine(PKA)HMM predict
734Phosphoserine(PKB)HMM predict
788Phosphotyrosine(INSR)HMM predict
788SulfotyrosineHMM predict
838N-linkedHMM predict
840Phosphoserine(CK1)HMM predict
840Phosphoserine(ATM)HMM predict
844Phosphoserine(IKK)HMM predict
851N-linkedHMM predict
858O-linkedHMM predict
859N-linkedHMM predict
866Phosphoserine(CDC2)HMM predict
876N-linkedHMM predict
881N-linkedHMM predict
886Phosphoserine(IKK)HMM predict
893Phosphoserine(IKK)HMM predict
905Phosphoserine(CDC2)HMM predict
908N-linkedHMM predict
911N-linkedHMM predict
933Phosphothreonine(PKC)HMM predict
975N-linkedHMM predict
977O-linkedHMM predict
977O-linkedHMM predict
980O-linkedHMM predict
980Phosphoserine(CK1)HMM predict
980Phosphoserine(IKK)HMM predict
983O-linkedHMM predict
1012Phosphoserine(ATM)HMM predict
1027O-linkedHMM predict
1028O-linkedHMM predict
1045Phosphoserine(IKK)HMM predict
1069O-linkedHMM predict
1073O-linkedHMM predict
1079Phosphothreonine(MAPK)HMM predict
1112Phosphothreonine(PKC)HMM predict
1134Phosphoserine(ATM)HMM predict
1140Phosphoserine(IKK)HMM predict
1143Phosphoserine(CDC2)HMM predict
1146Phosphoserine(CK2)HMM predict
1147Phosphoserine(CK2)HMM predict
1171Phosphoserine(CDC2)HMM predict
1220Phosphoserine(CK1)HMM predict
1224Phosphoserine(IKK)HMM predict
1318N-linkedHMM predict
1320Phosphoserine(CK1)HMM predict
1320Phosphoserine(CK2)HMM predict
1349Phosphotyrosine(Jak)HMM predict
1387Phosphothreonine(CDC2)HMM predict
1387Phosphothreonine(MAPK)HMM predict
1387Phosphothreonine(CDK)HMM predict
1400O-linkedHMM predict
1400O-linkedHMM predict
1424Phosphoserine(ATM)HMM predict
1458Phosphotyrosine(EGFR)HMM predict
1458Phosphotyrosine(SRC)HMM predict
1458Phosphotyrosine(Abl)HMM predict
1458Phosphotyrosine(Syk)HMM predict
1458SulfotyrosineHMM predict
1461Phosphothreonine(PKC)HMM predict
1468Phosphoserine(CDC2)HMM predict
1468Phosphoserine(IKK)HMM predict
1471Phosphoserine(CDC2)HMM predict
1474Phosphoserine(CK2)HMM predict
1474PhosphoserineHMM predict
1475Phosphoserine(CK2)HMM predict
1475Phosphoserine(ATM)HMM predict
1479Phosphoserine(CK1)HMM predict
1479Phosphoserine(CK2)HMM predict
1530O-linkedHMM predict
1538O-linkedHMM predict
1538Phosphoserine(CDC2)HMM predict
1555Phosphoserine(IKK)HMM predict
1620Phosphoserine(ATM)HMM predict
1636Phosphothreonine(MAPK)HMM predict
1737O-linkedHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_001002838
  • Location:chrX 54239579-54401162
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
H3K27me3 colorectalcancer 54402253 54403670 1417 1799
Oct1 HelaGSE14283 54418152 54418204 52 17016
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
ER E2-MCF7GSE14664 54248290 54248327 37 0
ER E2-MCF7GSE14664 54264970 54265049 79 0
ER Fulvestrant-MCF7GSE14664 54248294 54248330 36 0
FOXA1 MCF7GSE15244 54331187 54331822 635 0
H3K27me3 colorectalcancer 54399667 54400768 1101 0
Oct1 H2O2-HelaGSE14283 54249524 54249565 41 0
Oct1 HelaGSE14283 54248290 54248330 40 0
Oct1 HelaGSE14283 54273157 54273192 35 0
Oct1 HelaGSE14283 54273352 54273406 54 0
Oct1 HelaGSE14283 54282251 54282285 34 0
Oct1 HelaGSE14283 54302242 54302270 28 0
Oct1 HelaGSE14283 54336812 54336877 65 0
Oct1 HelaGSE14283 54349668 54349700 32 0
Oct1 HelaGSE14283 54352857 54352910 53 0
Oct1 HelaGSE14283 54361006 54361044 38 0
RNAII Tamoxifen-MCF7GSE14664 54377390 54377449 59 0
hScc1 CdLSGSE12603 54291403 54291773 370 0
hScc1 G2GSE9613 54291403 54291735 332 0
p130 SenescentGSE19898 54251760 54252033 273 0
p63 keratinocytesGSE17611 54339531 54340396 865 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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