AutismKB 2.0

Annotation Detail for WNK2


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Basic Information Top
Gene Symbol:WNK2 ( KIAA1760,NY-CO-43,P/OKcl.13,PRKWNK2,SDCCAG43 )
Gene Full Name: WNK lysine deficient protein kinase 2
Band: 9q22.31
Quick LinksEntrez ID:65268; OMIM: 606249; Uniprot ID:WNK2_HUMAN; ENSEMBL ID: ENSG00000165238; HGNC ID: 14542
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
49Phosphoserine.
352Phosphoserine; by autocatalysis (By
356Phosphoserine; by autocatalysis (By
1817Phosphoserine.
1818Phosphoserine.
1862Phosphoserine.
1889Phosphoserine.
Location(AA) Modifications Resource
352Phosphoserine (by autocatalysis) (Bysimilarity).Swiss-Prot 53.0
356Phosphoserine (by autocatalysis) (Bysimilarity).Swiss-Prot 53.0
Location(AA) Modification Resource
19MethylarginineHMM predict
121O-linkedHMM predict
150Phosphothreonine(PKC)HMM predict
168Phosphothreonine(PKC)HMM predict
352Phosphoserine(PKA)HMM predict
352PhosphoserineHMM predict
369Phosphotyrosine(EGFR)HMM predict
373SulfotyrosineHMM predict
394SulfotyrosineHMM predict
406Phosphotyrosine(EGFR)HMM predict
473Phosphothreonine(PKA)HMM predict
560Phosphoserine(CDC2)HMM predict
560Phosphoserine(CDK)HMM predict
605O-linkedHMM predict
608O-linkedHMM predict
609O-linkedHMM predict
614Phosphoserine(CK2)HMM predict
653Phosphoserine(MAPK)HMM predict
657O-linkedHMM predict
668Phosphoserine(MAPK)HMM predict
676O-linkedHMM predict
676O-linkedHMM predict
685O-linkedHMM predict
714O-linkedHMM predict
715O-linkedHMM predict
715Phosphothreonine(MAPK)HMM predict
738O-linkedHMM predict
738Phosphothreonine(MAPK)HMM predict
805Phosphothreonine(MAPK)HMM predict
824O-linkedHMM predict
835Phosphoserine(CDC2)HMM predict
851O-linkedHMM predict
851Phosphoserine(MAPK)HMM predict
927O-linkedHMM predict
927Phosphoserine(CDC2)HMM predict
949O-linkedHMM predict
961O-linkedHMM predict
1018O-linkedHMM predict
1018Phosphothreonine(MAPK)HMM predict
1041O-linkedHMM predict
1051O-linkedHMM predict
1075O-linkedHMM predict
1075Phosphothreonine(PKC)HMM predict
1085O-linkedHMM predict
1089O-linkedHMM predict
1124Phosphoserine(ATM)HMM predict
1134PhosphoserineHMM predict
1145Phosphoserine(CK1)HMM predict
1152PhosphoserineHMM predict
1175Phosphothreonine(PKA)HMM predict
1175Phosphothreonine(PKC)HMM predict
1179Phosphoserine(PKG)HMM predict
1262Phosphoserine(CK2)HMM predict
1262PhosphoserineHMM predict
1271Phosphoserine(CK1)HMM predict
1276O-linkedHMM predict
1294Phosphoserine(PKG)HMM predict
1301Phosphotyrosine(Abl)HMM predict
1330O-linkedHMM predict
1330Phosphoserine(ATM)HMM predict
1336Phosphoserine(CDC2)HMM predict
1337O-linkedHMM predict
1351Phosphothreonine(PKA)HMM predict
1354S-palmitoylHMM predict
1374Phosphoserine(CK2)HMM predict
1377Phosphoserine(CDK)HMM predict
1386Phosphotyrosine(Syk)HMM predict
1391Phosphoserine(CK1)HMM predict
1391Phosphoserine(CK2)HMM predict
1392Phosphoserine(CK1)HMM predict
1406Phosphoserine(ATM)HMM predict
1411O-linkedHMM predict
1424O-linkedHMM predict
1425O-linkedHMM predict
1425Phosphoserine(ATM)HMM predict
1429O-linkedHMM predict
1429O-linkedHMM predict
1441O-linkedHMM predict
1442O-linkedHMM predict
1448O-linkedHMM predict
1448O-linkedHMM predict
1448Phosphoserine(CK2)HMM predict
1448Phosphoserine(IKK)HMM predict
1452Phosphoserine(ATM)HMM predict
1459Phosphothreonine(CDK)HMM predict
1470Phosphoserine(ATM)HMM predict
1494Phosphothreonine(CDC2)HMM predict
1494Phosphothreonine(MAPK)HMM predict
1502Phosphothreonine(PKC)HMM predict
1506Phosphoserine(CAMK2)HMM predict
1506Phosphoserine(PKB)HMM predict
1506PhosphoserineHMM predict
1520O-linkedHMM predict
1523O-linkedHMM predict
1523Phosphoserine(IKK)HMM predict
1523PhosphoserineHMM predict
1525O-linkedHMM predict
1525Phosphothreonine(CDK)HMM predict
1549Phosphoserine(ATM)HMM predict
1549Phosphoserine(IKK)HMM predict
1553O-linkedHMM predict
1559O-linkedHMM predict
1566Phosphoserine(IKK)HMM predict
1605O-linkedHMM predict
1605O-linkedHMM predict
1606O-linkedHMM predict
1608O-linkedHMM predict
1737O-linkedHMM predict
1743O-linkedHMM predict
1743O-linkedHMM predict
1765Phosphoserine(CDC2)HMM predict
1777Phosphoserine(CDC2)HMM predict
1777Phosphoserine(CDK)HMM predict
1798Phosphoserine(CDK)HMM predict
1811Phosphotyrosine(Syk)HMM predict
1817Phosphoserine(CK1)HMM predict
1818Phosphoserine(CDC2)HMM predict
1818Phosphoserine(MAPK)HMM predict
1818Phosphoserine(ATM)HMM predict
1830Phosphothreonine(PKC)HMM predict
1844Phosphoserine(CK1)HMM predict
1866O-linkedHMM predict
1868Phosphoserine(IKK)HMM predict
1889Phosphoserine(PKG)HMM predict
1894Phosphothreonine(CDC2)HMM predict
1894Phosphothreonine(MAPK)HMM predict
1908O-linkedHMM predict
1918Phosphoserine(CK2)HMM predict
1919Phosphoserine(ATM)HMM predict
1921N-linkedHMM predict
1923Phosphoserine(CK1)HMM predict
1923Phosphoserine(CK2)HMM predict
1980Phosphothreonine(PKC)HMM predict
1986Phosphothreonine(PKA)HMM predict
1986Phosphothreonine(PKC)HMM predict
1987Phosphoserine(PKG)HMM predict
1987Phosphoserine(CAMK2)HMM predict
2052Phosphoserine(ATM)HMM predict
2056Phosphoserine(PKG)HMM predict
2056Phosphoserine(IKK)HMM predict
2088Phosphothreonine(PKC)HMM predict
2091Phosphoserine(CDC2)HMM predict
2125Phosphoserine(CK1)HMM predict
2126Phosphoserine(CK1)HMM predict
2128O-linkedHMM predict
2128Phosphoserine(IKK)HMM predict
2129O-linkedHMM predict
2211Phosphothreonine(PKC)HMM predict
2231O-linkedHMM predict
2242O-linkedHMM predict
2242Phosphoserine(ATM)HMM predict
2277MethylarginineHMM predict
2282ValineHMM predict
2288Phosphoserine(PKA)HMM predict
2288Phosphoserine(CAMK2)HMM predict
2288Phosphoserine(IKK)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_006648
  • Location:chr9 94987032-95122673
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
ER Fulvestrant-MCF7GSE14664 94973760 94973795 35 13255
Oct1 HelaGSE14283 94973759 94973795 36 13256
hScc1 BcellGSE12603 94985985 94987567 1582 257
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Oct1 HelaGSE14283 95127629 95127667 38 4975
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP JurkatGSE17954 95070396 95072088 1692 0
CTCF CD4GSE12889 95104868 95105060 192 0
CTCF CD4SISSRdata 95104868 95105060 192 0
ER Fulvestrant-MCF7GSE14664 95027786 95027858 72 0
FOXA1 MCF7GSE15244 95003378 95004994 1616 0
FOXA1 MCF7GSE15244 95025084 95027178 2094 0
Myc hESGSE17917 95026572 95026833 261 0
NFkBII GM15510GSE19485 95070514 95071795 1281 0
NFkBII GM18526GSE19485 95070618 95071945 1327 0
Oct1 H2O2-HelaGSE14283 95073193 95073222 29 0
Oct1 HelaGSE14283 95049420 95049458 38 0
P300 T30-glioblastomaGSE21026 95025228 95025866 638 0
P300 T30-glioblastomaGSE21026 95114930 95115583 653 0
RARA MCF7GSE15244 95003378 95004811 1433 0
Rb GrowingGSE19898 95027991 95028150 159 0
Rb shRbQuiescentGSE19898 95031745 95031995 250 0
TFAP2C MCF7GSE21234 94999811 95000639 828 0
TFAP2C MCF7GSE21234 95003171 95005247 2076 0
TFAP2C MCF7GSE21234 95025230 95026219 989 0
TFAP2C MCF7GSE21234 95026319 95027366 1047 0
TFAP2C MCF7GSE21234 95103846 95104500 654 0
hScc1 BcellGSE12603 95058246 95058653 407 0
hScc1 BcellGSE12603 95061069 95061711 642 0
hScc1 BcellGSE12603 95063708 95064153 445 0
hScc1 BcellGSE12603 95067028 95067190 162 0
hScc1 BcellGSE12603 95091045 95091587 542 0
hScc1 BcellGSE12603 95104764 95104989 225 0
hScc1 BcellGSE12603 95105322 95105650 328 0
hScc1 BcellGSE12603 95106947 95107252 305 0
hScc1 CdLSGSE12603 95104764 95104989 225 0
hScc1 G2GSE9613 95106585 95107433 848 0
p63 keratinocytesGSE17611 95026525 95027442 917 0
Validated miRNA targets Top
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
26742 mRNA WNK2 chr9 93026766 93162409 217 EST chr9 93107205 93110018Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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