AutismKB 2.0

Annotation Detail for SMO


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Basic Information Top
Gene Symbol:SMO ( Gx,SMOH )
Gene Full Name: smoothened homolog (Drosophila)
Band: 7q32.1
Quick LinksEntrez ID:6608; OMIM: 601500; Uniprot ID:SMO_HUMAN; ENSEMBL ID: ENSG00000128602; HGNC ID: 11119
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
35N-linked (GlcNAc...) (Potential).
188N-linked (GlcNAc...) (Potential).
309N-linked (GlcNAc...) (Potential).
785Phosphoserine.
Location(AA) Modifications Resource
35N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
188N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
309N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
Location(AA) Modification Resource
35N-linkedHMM predict
51Phosphoserine(PKG)HMM predict
98Phosphoserine(CK1)HMM predict
98Phosphoserine(ATM)HMM predict
98PhosphoserineHMM predict
188N-linkedHMM predict
207Phosphotyrosine(Syk)HMM predict
309N-linkedHMM predict
342O-linkedHMM predict
446N-linkedHMM predict
640Phosphothreonine(MAPK)HMM predict
644O-linkedHMM predict
699O-linkedHMM predict
742PhosphoserineHMM predict
769IsoleucineHMM predict
771SerineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_005631
  • Location:chr7 128615948-128640618
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 128615599 128616191 592 54
H3K27me3 colorectalcancer 128614190 128615283 1093 1212
Oct1 H2O2-HelaGSE14283 128608758 128608795 37 7172
Oct1 HelaGSE14283 128607343 128607390 47 8582
Oct1 HelaGSE14283 128608758 128608796 38 7172
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 128645717 128646009 292 5245
CTCF CD4SISSRdata 128645717 128646009 292 5245
CTCF HelaGSE12889 128645660 128645975 315 5199
CTCF JurkatGSE12889 128645684 128645996 312 5222
CTCF G2GSE9613 128640967 128641531 564 631
CTCF G2GSE9613 128645772 128646043 271 5289
Fos K562GSE19551 128645602 128646057 455 5211
Myc K562GSE19551 128645566 128646069 503 5199
NRSF JurkatSISSRdata 128645738 128646054 316 5278
NRSF mAbJurkat 128645772 128646125 353 5330
STAT1 IFNSISSRdata 128645615 128646074 459 5226
hScc1 BcellGSE12603 128645772 128646162 390 5349
hScc1 CdLSGSE12603 128640967 128641280 313 505
hScc1 CdLSGSE12603 128645772 128646125 353 5330
hScc1 G2GSE9613 128645772 128646125 353 5330
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 128637579 128637854 275 0
CTCF CD4SISSRdata 128637579 128637854 275 0
CTCF JurkatGSE12889 128637639 128637813 174 0
CTCF G2GSE9613 128632161 128632834 673 0
CTCF G2GSE9613 128635864 128636705 841 0
CTCF G2GSE9613 128637422 128638203 781 0
CTCF G2GSE9613 128638731 128639256 525 0
H3K27me3 colorectalcancer 128616679 128617403 724 0
H3K4me3 colorectalcancer 128616861 128617216 355 0
H3ac HepG2E 128616679 128617478 799 0
Oct1 H2O2-HelaGSE14283 128628675 128628705 30 0
Oct1 HelaGSE14283 128633490 128633529 39 0
hScc1 BcellGSE12603 128637422 128638239 817 0
hScc1 CdLSGSE12603 128637518 128638275 757 0
hScc1 G2GSE9613 128637422 128638032 610 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-let-7a hsa-let-7a-1 9 20216554
hsa-let-7a hsa-let-7a-2 11 20216554
hsa-let-7a hsa-let-7a-3 22 20216554
hsa-let-7a* hsa-let-7a-1 9 20216554
hsa-let-7a* hsa-let-7a-3 22 20216554
hsa-let-7b hsa-let-7b 22 20216554
hsa-let-7b* hsa-let-7b 22 20216554
hsa-let-7c hsa-let-7c 21 20216554
hsa-let-7c* hsa-let-7c 21 20216554
hsa-let-7d hsa-let-7d 9 20216554
hsa-let-7d* hsa-let-7d 9 20216554
hsa-let-7e hsa-let-7e 19 20216554
hsa-let-7e* hsa-let-7e 19 20216554
hsa-let-7f hsa-let-7f-1 9 20216554
hsa-let-7f hsa-let-7f-2 X 20216554
hsa-let-7f-1* hsa-let-7f-1 9 20216554
hsa-let-7f-2* hsa-let-7f-2 X 20216554
hsa-let-7g hsa-let-7g 3 20216554
hsa-let-7g* hsa-let-7g 3 20216554
hsa-let-7i hsa-let-7i 12 20216554
hsa-let-7i* hsa-let-7i 12 20216554
hsa-miR-125b hsa-mir-125b-1 11 20216554
hsa-miR-125b hsa-mir-125b-2 21 20216554
hsa-miR-126 hsa-mir-126 9 20216554
hsa-miR-126* hsa-mir-126 9 20216554
hsa-miR-15a hsa-mir-15a 13 20216554
hsa-miR-15a* hsa-mir-15a 13 20216554
hsa-miR-15b hsa-mir-15b 3 20216554
hsa-miR-15b* hsa-mir-15b 3 20216554
hsa-miR-16 hsa-mir-16-1 13 20216554
hsa-miR-16 hsa-mir-16-2 3 20216554
hsa-miR-203 hsa-mir-203 14 20216554
hsa-miR-21 hsa-mir-21 17 20216554
hsa-miR-21* hsa-mir-21 17 20216554
hsa-miR-216a hsa-mir-216a 2 20216554
hsa-miR-217 hsa-mir-217 2 20216554
hsa-miR-23b hsa-mir-23b 9 20216554
hsa-miR-23b* hsa-mir-23b 9 20216554
hsa-miR-324-5p hsa-mir-324 17 20216554
hsa-miR-326 hsa-mir-326 11 20216554
hsa-miR-372 hsa-mir-372 19 20216554
hsa-miR-373 hsa-mir-373 19 20216554
hsa-miR-373* hsa-mir-373 19 20216554
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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