Annotation Detail for SOD2

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Basic Information Top

Gene Symbol:	SOD2 ( IPOB,MNSOD,MVCD6 )
Gene Full Name:	superoxide dismutase 2, mitochondrial
Band:	6q25.3
Quick Links	Entrez ID:6648; OMIM: 147460; Uniprot ID:SODM_HUMAN; ENSEMBL ID: ENSG00000112096; HGNC ID: 11180
Relate to Another Database:	SFARIGene; denovo-db

Pathways, Diseases and Drugs

TF binding site

Post Translation Modification

PTM Sites from Uniprot:3 results
Experimental PTM Sites from dbPTM:1 results
Predicted PTM Sites by profile HMM from dbPTM:7 results

Location(AA)	Modification
58	Nitrated tyrosine.
68	N6-acetyllysine.
130	N6-acetyllysine.

Location(AA)	Modification	Resource
19	Phosphotyrosine(Jak)	HMM predict
27	Phosphoserine(IKK)	HMM predict
35	Sulfotyrosine	HMM predict
63	N-linked	HMM predict
97	N-linked	HMM predict
106	Phosphoserine(CDC2)	HMM predict
212	N-linked	HMM predict

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

RefSeq ID: NM_000636
Location:chr6 160022744-160034342
strand:-

Upstream the gene:12 results
Downstream the gene:0 results
Inside the gene:17 results

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CBP	T30-glioblastoma	GSE21026	160042312	160043255	943	8441
H3K4me3	colorectal	cancer	160035121	160035484	363	960
H3ac	HepG2	E	160035976	160036503	527	1897
Myc	hES	GSE17917	160034298	160034624	326	119
P300	T0-glioblastoma	GSE21026	160042390	160043229	839	8467
P300	T30-glioblastoma	GSE21026	160042129	160043315	1186	8380
PHF8	HeLa	GSE20725	160033610	160035271	1661	98
Rb	Senescent	GSE19898	160037153	160037314	161	2891
STAT1	HeLa	GSE12783	160032730	160035975	3245	10
TAF	k562	GSE8489	160035010	160035562	552	944
p130	shRbSenescent	GSE19898	160034386	160034662	276	182
p130	shRbSenescent	GSE19898	160034704	160034860	156	440

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CTCF	G2	GSE9613	160032285	160032658	373	0
CTCF	G2	GSE9613	160033829	160034568	739	0
H3K4me2	HCT116	GSE10453	160033145	160033530	385	0
H3K4me3	colorectal	cancer	160033145	160033684	539	0
H3ac	HepG2	E	160029669	160030466	797	0
H3ac	HepG2	E	160032165	160033757	1592	0
KLF4	hES	GSE17917	160034105	160034507	402	0
Rb	shRbSenescence	GSE19898	160033750	160033973	223	0
STAT1	HeLa	GSE12782	160031579	160036037	4458	0
STAT1	HeLa	GSE12783	160031718	160032684	966	0
STAT1	IFN	SISSRdata	160031700	160033441	1741	0
TAF	Hela	GSE8489	160032240	160033604	1364	0
TAF	k562	GSE8489	160032332	160033640	1308	0
hScc1	Bcell	GSE12603	160032240	160032606	366	0
hScc1	Bcell	GSE12603	160033720	160034402	682	0
hScc1	CdLS	GSE12603	160032203	160032694	491	0
hScc1	G2	GSE9613	160032367	160032694	327	0

Validated miRNA targets

miR Walk:15 results
Tarbase V5.0:0 results

Micro RNA Name	Stem Loop Name	The chromosome that miRNA located	Publication
hsa-miR-145	hsa-mir-145	5	19142192
hsa-miR-145*	hsa-mir-145	5	19142192
hsa-miR-155	hsa-mir-155	21	20078880
hsa-miR-155*	hsa-mir-155	21	20078880
hsa-miR-17	hsa-mir-17	13	21203553
hsa-miR-17*	hsa-mir-17	13	21203553
hsa-miR-222	hsa-mir-222	X	19487542
hsa-miR-222*	hsa-mir-222	X	19487542
hsa-miR-30a	hsa-mir-30a	6	16450009
hsa-miR-30a*	hsa-mir-30a	6	16450009
hsa-miR-377	hsa-mir-377	14	18716028
hsa-miR-377*	hsa-mir-377	14	18716028
hsa-miR-382	hsa-mir-382	14	20716515
hsa-miR-92a	hsa-mir-92a-1	13	21203553
hsa-miR-92a	hsa-mir-92a-2	X	21203553

Cis-Nats regulation

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

Studies: 1,036
Genes: 1,379
CNVs/SVs: 5,420
SNVs/Indels: 11,669
de novo Mutations: 5,669
Mosaics: 789
Linkage Regions: 172

Paper Collected: 6/30/2018

Last Update: 8/26/2018

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