AutismKB 2.0

Annotation Detail for SP1


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Basic Information Top
Gene Symbol:SP1 ( - )
Gene Full Name: Sp1 transcription factor
Band: 12q13.13
Quick LinksEntrez ID:6667; OMIM: 189906; Uniprot ID:SP1_HUMAN; ENSEMBL ID: ENSG00000185591; HGNC ID: 11205
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
7Phosphoserine (By similarity).
59Phosphoserine.
101Phosphoserine; by ATM.
278Phosphothreonine; by MAPK8.
453Phosphothreonine; by MAPK1 AND MAPK3.
491O-linked (GlcNAc).
612Phosphoserine; alternate.
612O-linked (GlcNAc); alternate.
640O-linked (GlcNAc); alternate.
640Phosphothreonine; alternate.
641O-linked (GlcNAc); alternate.
641Phosphoserine; by PKC/PRKCZ; alternate.
651Phosphothreonine; by PKC/PRKCZ.
668Phosphothreonine.
670Phosphoserine; by PKC/PRKCZ.
681Phosphothreonine; by PKC/PRKCZ.
698O-linked (GlcNAc).
702Phosphoserine; alternate.
702O-linked (GlcNAc); alternate.
703N6-acetyllysine.
739Phosphothreonine; by MAPK1, MAPK3 AND
Location(AA) Modifications Resource
7Phosphoserine (By similarity).Swiss-Prot 53.0
59Phosphoserine.Swiss-Prot 53.0
59PhosphoserinePhospho.ELM 6.0
453Phosphothreonine (MAPK1;MAPK3)Phospho.ELM 6.0
579Phosphothreonine (CK2
739Phosphothreonine (MAPK1;MAPK3)Phospho.ELM 6.0
Location(AA) Modification Resource
7Phosphoserine(IKK)HMM predict
36Phosphoserine(ATM)HMM predict
41Phosphoserine(CK1)HMM predict
42Phosphoserine(PKB)HMM predict
42Phosphoserine(CK1)HMM predict
42Phosphoserine(IKK)HMM predict
43O-linkedHMM predict
45Phosphoserine(IKK)HMM predict
48O-linkedHMM predict
56Phosphoserine(ATM)HMM predict
56Phosphoserine(IKK)HMM predict
79N-linkedHMM predict
80N-linkedHMM predict
85Phosphoserine(ATM)HMM predict
87Phosphoserine(ATM)HMM predict
114O-linkedHMM predict
114Phosphoserine(IKK)HMM predict
117Phosphothreonine(CDC2)HMM predict
117Phosphothreonine(MAPK)HMM predict
117O-linkedHMM predict
117O-linkedHMM predict
119O-linkedHMM predict
124Phosphoserine(IKK)HMM predict
129N-linkedHMM predict
132N-linkedHMM predict
139N-linkedHMM predict
147Phosphotyrosine(INSR)HMM predict
263N-linkedHMM predict
273O-linkedHMM predict
278Phosphothreonine(CDK)HMM predict
278Phosphothreonine(MAPK)HMM predict
278O-linkedHMM predict
280O-linkedHMM predict
281Phosphoserine(ATM)HMM predict
285O-linkedHMM predict
291Phosphoserine(CK1)HMM predict
291Phosphoserine(ATM)HMM predict
291Phosphoserine(IKK)HMM predict
294Phosphoserine(IKK)HMM predict
296Phosphoserine(ATM)HMM predict
300O-linkedHMM predict
303O-linkedHMM predict
304O-linkedHMM predict
309Phosphoserine(IKK)HMM predict
309O-linkedHMM predict
309O-linkedHMM predict
313Phosphoserine(ATM)HMM predict
328O-linkedHMM predict
330O-linkedHMM predict
331O-linkedHMM predict
332O-linkedHMM predict
340N-linkedHMM predict
351Phosphoserine(ATM)HMM predict
351Phosphoserine(IKK)HMM predict
355Phosphothreonine(CDC2)HMM predict
355Phosphothreonine(MAPK)HMM predict
373N-linkedHMM predict
427O-linkedHMM predict
431Phosphoserine(ATM)HMM predict
496O-linkedHMM predict
497Phosphoserine(IKK)HMM predict
499N-linkedHMM predict
500O-linkedHMM predict
501O-linkedHMM predict
503Phosphothreonine(MAPK)HMM predict
515O-linkedHMM predict
599Phosphothreonine(PKC)HMM predict
660C-linkedHMM predict
663S-palmitoylHMM predict
668Phosphothreonine(PKA)HMM predict
668Phosphothreonine(PKC)HMM predict
679Phosphothreonine(PKA)HMM predict
735O-linkedHMM predict
735O-linkedHMM predict
735Phosphoserine(IKK)HMM predict
737O-linkedHMM predict
739Phosphothreonine(MAPK)HMM predict
739O-linkedHMM predict
741O-linkedHMM predict
779N-linkedHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_138473
  • Location:chr12 52060245-52096490
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 52051060 52051253 193 9089
CTCF CD4SISSRdata 52051060 52051253 193 9089
FOXA1 MCF7GSE15244 52053901 52054109 208 6241
FOXA1 MCF7GSE15244 52058993 52060121 1128 689
H3ac HepG2E 52050792 52051073 281 9313
Oct1 H2O2-HelaGSE14283 52058712 52058740 28 1520
P300 T30-glioblastomaGSE21026 52058816 52060235 1419 720
PHF8 293TGSE20725 52058958 52059758 800 888
PHF8 Hs68plusFBSGSE20725 52058924 52060790 1866 389
RARA MCF7GSE15244 52050792 52051234 442 9233
RARA MCF7GSE15244 52053901 52054137 236 6227
RARA MCF7GSE15244 52058773 52059337 564 1191
RARG MCF7GSE15244 52050792 52051272 480 9214
RARG MCF7GSE15244 52058773 52059745 972 987
Rb GrowingGSE19898 52059893 52060192 299 203
Rb SenescentGSE19898 52051061 52051780 719 8825
Rb SenescentGSE19898 52059232 52060407 1175 426
TAF HelaGSE8489 52052695 52052884 189 7456
TAF k562GSE8489 52058773 52059108 335 1305
TFAP2C MCF7GSE21234 52050271 52051881 1610 9170
p130 QuiescentGSE19898 52051338 52051501 163 8826
p130 SenescentGSE19898 52050795 52051636 841 9030
p130 SenescentGSE19898 52058917 52060407 1490 584
p130 shRbQuiescentGSE19898 52050983 52051486 503 9011
p130 shRbQuiescentGSE19898 52051545 52051841 296 8553
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
FOXA1 MCF7GSE15244 52099645 52100193 548 3429
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 52061855 52063416 1561 0
FOXA1 MCF7GSE15244 52062394 52063378 984 0
H3K4me2 HCT116GSE10453 52062069 52062648 579 0
H3K4me3 colorectalcancer 52061319 52061600 281 0
H3ac HepG2E 52061319 52063885 2566 0
H3ac HepG2E 52065992 52066498 506 0
Nanog hESGSE18292 52070787 52071053 266 0
Oct1 H2O2-HelaGSE14283 52064305 52064335 30 0
Oct1 H2O2-HelaGSE14283 52096035 52096073 38 0
Oct1 HelaGSE14283 52064305 52064335 30 0
Oct1 HelaGSE14283 52066860 52066897 37 0
Oct1 HelaGSE14283 52096037 52096072 35 0
P300 T30-glioblastomaGSE21026 52067153 52067987 834 0
RARA MCF7GSE15244 52062394 52063914 1520 0
RARG MCF7GSE15244 52062394 52063885 1491 0
TAF HelaGSE8489 52061319 52061630 311 0
hScc1 CdLSGSE12603 52061818 52062322 504 0
hScc1 G2GSE9613 52061855 52062322 467 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-1 hsa-mir-1-2 18 15685193
hsa-miR-1 hsa-mir-1-1 20 15685193
hsa-miR-106a hsa-mir-106a X 19307576
hsa-miR-106a* hsa-mir-106a X 19307576
hsa-miR-124 hsa-mir-124-1 8 15685193
hsa-miR-124 hsa-mir-124-2 8 15685193
hsa-miR-124 hsa-mir-124-3 20 15685193
hsa-miR-373 hsa-mir-373 19 15685193
hsa-miR-373* hsa-mir-373 19 15685193
ID in Tarbase Data Type Support Type miRNA Gene Direct Support Publication
346 Unknown MicroArray miR-124 SP1 n_a 15685193
Ensembl Protein Type Differentially expressed in Pathology or Event Mis Regulation Gene Expression Tumour Involvement
ENSG00000185591 G1-to-S transition n_a n_a "lymphocyte, muscle cell" "benign tumour, malignant tumour, carcinoma, leukaemia, sarcoma"
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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