AutismKB 2.0

Annotation Detail for SPARC


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Basic Information Top
Gene Symbol:SPARC ( ON )
Gene Full Name: secreted protein, acidic, cysteine-rich (osteonectin)
Band: 5q33.1
Quick LinksEntrez ID:6678; OMIM: 182120; Uniprot ID:SPRC_HUMAN; ENSEMBL ID: ENSG00000113140; HGNC ID: 11219
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
116N-linked (GlcNAc...).
Location(AA) Modifications Resource
116N-linked (GlcNAc...) (Probable).Swiss-Prot 53.0
Location(AA) Modification Resource
10S-palmitoylHMM predict
62Phosphothreonine(CK2)HMM predict
88N-linkedHMM predict
89N-linkedHMM predict
100Phosphoserine(IKK)HMM predict
116N-linkedHMM predict
246Phosphotyrosine(Jak)HMM predict
280Phosphotyrosine(INSR)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_003118
  • Location:chr5 151021206-151046709
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 151057280 151057453 173 10657
CTCF G2GSE9613 151062154 151062285 131 15510
RARA MCF7GSE15244 151051531 151052534 1003 5323
TFAP2C MCF7GSE21234 151052046 151052709 663 5668
TFAP2C MCF7GSE21234 151061850 151062330 480 15381
VDR GM10861-stimGSE22484 151059629 151064031 4402 15121
p130 SenescentGSE19898 151046458 151047080 622 60
p130 SenescentGSE19898 151056195 151056994 799 9885
p130 shRbQuiescentGSE19898 151056171 151056935 764 9844
p130 shRbSenescentGSE19898 151056177 151057078 901 9918
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 151011835 151012200 365 9189
CTCF CD4GSE12889 151018752 151019020 268 2321
CTCF CD4SISSRdata 151011835 151012200 365 9189
CTCF CD4SISSRdata 151018752 151019020 268 2321
CTCF G2GSE9613 151016810 151017191 381 4206
CTCF G2GSE9613 151018831 151019191 360 2196
Myc K562GSE19551 151011787 151012202 415 9212
Oct4 hESGSE17917 151011889 151012127 238 9199
TAFII hESGSE17917 151011716 151012093 377 9302
TFAP2C MCF7GSE21234 151006077 151006692 615 14822
hScc1 BcellGSE12603 151011439 151011989 550 9493
hScc1 BcellGSE12603 151018831 151019346 515 2118
hScc1 CdLSGSE12603 151011649 151011989 340 9388
hScc1 CdLSGSE12603 151018831 151019310 479 2136
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 151042878 151043095 217 0
Fos K562GSE19551 151026688 151027011 323 0
RARA MCF7GSE15244 151044414 151045249 835 0
Rb GrowingGSE19898 151046431 151046732 301 0
Rb QuiescentGSE19898 151046479 151046884 405 0
Rb SenescentGSE19898 151046442 151046830 388 0
TFAP2C MCF7GSE21234 151044589 151045303 714 0
p130 QuiescentGSE19898 151044577 151044738 161 0
p130 QuiescentGSE19898 151045501 151045759 258 0
p130 QuiescentGSE19898 151045816 151046116 300 0
p130 QuiescentGSE19898 151046145 151046373 228 0
p130 QuiescentGSE19898 151046452 151046818 366 0
p130 shRbQuiescentGSE19898 151024784 151025131 347 0
p130 shRbQuiescentGSE19898 151042651 151043327 676 0
p130 shRbQuiescentGSE19898 151044420 151045879 1459 0
p130 shRbQuiescentGSE19898 151045917 151046232 315 0
p130 shRbQuiescentGSE19898 151046287 151047063 776 0
p130 shRbSenescentGSE19898 151031825 151032197 372 0
p130 shRbSenescentGSE19898 151046186 151047222 1036 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-155 hsa-mir-155 21 21339733
hsa-miR-155 hsa-mir-155 21 21125666
hsa-miR-155 hsa-mir-155 21 21038317
hsa-miR-155* hsa-mir-155 21 21339733
hsa-miR-155* hsa-mir-155 21 21125666
hsa-miR-155* hsa-mir-155 21 21038317
hsa-miR-203 hsa-mir-203 14 21125666
hsa-miR-203 hsa-mir-203 14 21038317
hsa-miR-23b hsa-mir-23b 9 21125666
hsa-miR-23b hsa-mir-23b 9 21038317
hsa-miR-23b* hsa-mir-23b 9 21125666
hsa-miR-23b* hsa-mir-23b 9 21038317
hsa-miR-29a hsa-mir-29a 7 18390668
hsa-miR-29a* hsa-mir-29a 7 18390668
hsa-miR-29b hsa-mir-29b-1 7 19956414
hsa-miR-29b hsa-mir-29b-2 1 19956414
hsa-miR-29b-1* hsa-mir-29b-1 7 19956414
hsa-miR-29c hsa-mir-29c 1 21125666
hsa-miR-29c hsa-mir-29c 1 21038317
hsa-miR-29c hsa-mir-29c 1 18390668
hsa-miR-29c* hsa-mir-29c 1 21125666
hsa-miR-29c* hsa-mir-29c 1 21038317
hsa-miR-29c* hsa-mir-29c 1 18390668
hsa-miR-369-5p hsa-mir-369 14 21125666
hsa-miR-369-5p hsa-mir-369 14 21038317
hsa-miR-370 hsa-mir-370 14 21125666
hsa-miR-370 hsa-mir-370 14 21038317
hsa-miR-450a hsa-mir-450a-1 X 21125666
hsa-miR-450a hsa-mir-450a-2 X 21125666
hsa-miR-450a hsa-mir-450a-1 X 21038317
hsa-miR-450a hsa-mir-450a-2 X 21038317
hsa-miR-542-5p hsa-mir-542 X 21125666
hsa-miR-542-5p hsa-mir-542 X 21038317
ID in Tarbase Data Type Support Type miRNA Gene Direct Support Publication
594 Unknown TRUE miR-29c SPARC Luciferase assay 18390668
Ensembl Protein Type Differentially expressed in Pathology or Event Mis Regulation Gene Expression Tumour Involvement
ENSG00000113140 nasopharyngeal epithelium nasopharyngeal carcinomas (NPC) down regulated muscle cell "benign tumour, malignant tumour, carcinoma, sarcoma"
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
21693 mRNA chr5 151036701 151047659 92 mRNA SPARC chr5 151021203 151046710Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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