AutismKB 2.0

Annotation Detail for SRC


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Basic Information Top
Gene Symbol:SRC ( ASV,SRC1,c-SRC,p60-Src )
Gene Full Name: v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
Band: 20q11.23
Quick LinksEntrez ID:6714; OMIM: 190090; Uniprot ID:SRC_HUMAN; ENSEMBL ID: ENSG00000197122; HGNC ID: 11283
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
17Phosphoserine.
35Phosphoserine.
69Phosphoserine.
74Phosphothreonine.
75Phosphoserine.
187Phosphotyrosine (By similarity).
419Phosphotyrosine; by autocatalysis.
439Phosphotyrosine.
501S-nitrosocysteine (By similarity).
511Phosphothreonine.
522Phosphotyrosine.
530Phosphotyrosine; by CSK.
Location(AA) Modifications Resource
2N-myristoyl glycine (By similarity).Swiss-Prot 53.0
11PhosphoserinePhospho.ELM 6.0
16Phosphoserine (PKA
17Phosphoserine.Swiss-Prot 53.0
69Phosphoserine.Swiss-Prot 53.0
74Phosphoserine (CDK5;CDK
75Phosphoserine.Swiss-Prot 53.0
96PhosphoserinePhospho.ELM 6.0
215Phosphotyrosine (Src)Phospho.ELM 6.0
337Phosphotyrosine (Src)Phospho.ELM 6.0
418Phosphotyrosine (Src;PDGFR al)Phospho.ELM 6.0
419Phosphotyrosine (by autocatalysis).Swiss-Prot 53.0
529Phosphotyrosine (Csk)Phospho.ELM 6.0
530Phosphotyrosine (by CSK).Swiss-Prot 53.0
Location(AA) Modification Resource
17Phosphoserine(PKG)HMM predict
17Phosphoserine(PKA)HMM predict
35Phosphoserine(ATM)HMM predict
35O-linkedHMM predict
37Phosphothreonine(CDC2)HMM predict
37Phosphothreonine(MAPK)HMM predict
37Phosphothreonine(CDK)HMM predict
37PhosphothreonineHMM predict
39Phosphoserine(IKK)HMM predict
68N-linkedHMM predict
75Phosphoserine(CDC2)HMM predict
75Phosphoserine(CDK)HMM predict
115N-linkedHMM predict
116N-linkedHMM predict
134Phosphotyrosine(INSR)HMM predict
134Phosphotyrosine(Jak)HMM predict
180Phosphoserine(CK2)HMM predict
245Phosphothreonine(PKA)HMM predict
246Phosphothreonine(PKA)HMM predict
250O-linkedHMM predict
250O-linkedHMM predict
290N-linkedHMM predict
299Phosphothreonine(PKC)HMM predict
329Phosphotyrosine(Jak)HMM predict
338Phosphotyrosine(Jak)HMM predict
338Phosphotyrosine(INSR)HMM predict
338Phosphotyrosine(SRC)HMM predict
338Phosphotyrosine(EGFR)HMM predict
338SulfotyrosineHMM predict
419Phosphotyrosine(INSR)HMM predict
419Phosphotyrosine(Syk)HMM predict
419PhosphotyrosineHMM predict
530Phosphotyrosine(SRC)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_005417
  • Location:chr20 35406501-35467232
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
H3ac HepG2E 35393138 35393477 339 13194
H3ac HepG2E 35399221 35399593 372 7095
H3ac HepG2E 35402192 35402803 611 4004
H3ac HepG2E 35405156 35405893 737 977
NFkBII GM12878GSE19485 35397040 35400209 3169 7877
NFkBII GM12892GSE19485 35397216 35399450 2234 8169
NFkBII GM18526GSE19485 35395163 35396373 1210 10734
NFkBII GM18526GSE19485 35397231 35400019 2788 7877
TFAP2C MCF7GSE21234 35405290 35405851 561 931
hScc1 BcellGSE12603 35398446 35398806 360 7876
hScc1 BcellGSE12603 35403326 35403833 507 2922
p63 keratinocytesGSE17611 35393482 35394754 1272 12384
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
H3ac HepG2E 35406978 35407585 607 0
PHF8 HeLaGSE20725 35407433 35408189 756 0
hScc1 BcellGSE12603 35407585 35408310 725 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-let-7a hsa-let-7a-1 9 20486857
hsa-let-7a hsa-let-7a-2 11 20486857
hsa-let-7a hsa-let-7a-3 22 20486857
hsa-let-7a hsa-let-7a-1 9 19592657
hsa-let-7a hsa-let-7a-2 11 19592657
hsa-let-7a hsa-let-7a-3 22 19592657
hsa-let-7a hsa-let-7a-1 9 20459595
hsa-let-7a hsa-let-7a-2 11 20459595
hsa-let-7a hsa-let-7a-3 22 20459595
hsa-let-7a hsa-let-7a-1 9 19878981
hsa-let-7a hsa-let-7a-2 11 19878981
hsa-let-7a hsa-let-7a-3 22 19878981
hsa-let-7a* hsa-let-7a-1 9 20486857
hsa-let-7a* hsa-let-7a-3 22 20486857
hsa-let-7a* hsa-let-7a-1 9 19592657
hsa-let-7a* hsa-let-7a-3 22 19592657
hsa-let-7a* hsa-let-7a-1 9 20459595
hsa-let-7a* hsa-let-7a-3 22 20459595
hsa-let-7a* hsa-let-7a-1 9 19878981
hsa-let-7a* hsa-let-7a-3 22 19878981
hsa-let-7b hsa-let-7b 22 20486857
hsa-let-7b hsa-let-7b 22 19592657
hsa-let-7b hsa-let-7b 22 20459595
hsa-let-7b hsa-let-7b 22 19878981
hsa-let-7b* hsa-let-7b 22 20486857
hsa-let-7b* hsa-let-7b 22 19592657
hsa-let-7b* hsa-let-7b 22 20459595
hsa-let-7b* hsa-let-7b 22 19878981
hsa-let-7c hsa-let-7c 21 20486857
hsa-let-7c hsa-let-7c 21 19592657
hsa-let-7c hsa-let-7c 21 20459595
hsa-let-7c hsa-let-7c 21 19878981
hsa-let-7c* hsa-let-7c 21 20486857
hsa-let-7c* hsa-let-7c 21 19592657
hsa-let-7c* hsa-let-7c 21 20459595
hsa-let-7c* hsa-let-7c 21 19878981
hsa-let-7d hsa-let-7d 9 20486857
hsa-let-7d hsa-let-7d 9 19592657
hsa-let-7d hsa-let-7d 9 20459595
hsa-let-7d hsa-let-7d 9 19878981
hsa-let-7d* hsa-let-7d 9 20486857
hsa-let-7d* hsa-let-7d 9 19592657
hsa-let-7d* hsa-let-7d 9 20459595
hsa-let-7d* hsa-let-7d 9 19878981
hsa-let-7e hsa-let-7e 19 20486857
hsa-let-7e hsa-let-7e 19 19592657
hsa-let-7e hsa-let-7e 19 20459595
hsa-let-7e hsa-let-7e 19 19878981
hsa-let-7e* hsa-let-7e 19 20486857
hsa-let-7e* hsa-let-7e 19 19592657
hsa-let-7e* hsa-let-7e 19 20459595
hsa-let-7e* hsa-let-7e 19 19878981
hsa-let-7f hsa-let-7f-1 9 20486857
hsa-let-7f hsa-let-7f-2 X 20486857
hsa-let-7f hsa-let-7f-1 9 19592657
hsa-let-7f hsa-let-7f-2 X 19592657
hsa-let-7f hsa-let-7f-1 9 20459595
hsa-let-7f hsa-let-7f-2 X 20459595
hsa-let-7f hsa-let-7f-1 9 19878981
hsa-let-7f hsa-let-7f-2 X 19878981
hsa-let-7f-1* hsa-let-7f-1 9 20486857
hsa-let-7f-1* hsa-let-7f-1 9 19592657
hsa-let-7f-1* hsa-let-7f-1 9 20459595
hsa-let-7f-1* hsa-let-7f-1 9 19878981
hsa-let-7f-2* hsa-let-7f-2 X 20486857
hsa-let-7f-2* hsa-let-7f-2 X 19592657
hsa-let-7f-2* hsa-let-7f-2 X 20459595
hsa-let-7f-2* hsa-let-7f-2 X 19878981
hsa-let-7g hsa-let-7g 3 20486857
hsa-let-7g hsa-let-7g 3 19592657
hsa-let-7g hsa-let-7g 3 20459595
hsa-let-7g hsa-let-7g 3 19878981
hsa-let-7g* hsa-let-7g 3 20486857
hsa-let-7g* hsa-let-7g 3 19592657
hsa-let-7g* hsa-let-7g 3 20459595
hsa-let-7g* hsa-let-7g 3 19878981
hsa-let-7i hsa-let-7i 12 20486857
hsa-let-7i hsa-let-7i 12 19592657
hsa-let-7i hsa-let-7i 12 20459595
hsa-let-7i hsa-let-7i 12 19878981
hsa-let-7i* hsa-let-7i 12 20486857
hsa-let-7i* hsa-let-7i 12 19592657
hsa-let-7i* hsa-let-7i 12 20459595
hsa-let-7i* hsa-let-7i 12 19878981
hsa-miR-10b hsa-mir-10b 2 20843787
hsa-miR-10b* hsa-mir-10b 2 20843787
hsa-miR-126 hsa-mir-126 9 19767772
hsa-miR-126* hsa-mir-126 9 19767772
hsa-miR-143 hsa-mir-143 5 20351064
hsa-miR-143* hsa-mir-143 5 20351064
hsa-miR-145 hsa-mir-145 5 20351064
hsa-miR-145* hsa-mir-145 5 20351064
hsa-miR-155 hsa-mir-155 21 19359473
hsa-miR-155* hsa-mir-155 21 19359473
hsa-miR-205 hsa-mir-205 1 21330408
hsa-miR-218 hsa-mir-218-1 4 19767772
hsa-miR-218 hsa-mir-218-2 5 19767772
hsa-miR-221 hsa-mir-221 X 19859555
hsa-miR-221* hsa-mir-221 X 19859555
hsa-miR-222 hsa-mir-222 X 19859555
hsa-miR-222* hsa-mir-222 X 19859555
hsa-miR-224 hsa-mir-224 X 19767772
hsa-miR-337-5p hsa-mir-337 14 19290526
hsa-miR-346 hsa-mir-346 10 19878981
hsa-miR-489 hsa-mir-489 7 20700123
hsa-miR-98 hsa-mir-98 X 20486857
hsa-miR-98 hsa-mir-98 X 19592657
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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