AutismKB 2.0

Annotation Detail for SRM


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Basic Information Top
Gene Symbol:SRM ( PAPT,SPDSY,SPS1,SRML1 )
Gene Full Name: spermidine synthase
Band: 1p36.22
Quick LinksEntrez ID:6723; OMIM: 182891; Uniprot ID:SPEE_HUMAN; ENSEMBL ID: ENSG00000116649; HGNC ID: 11296
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
1N-acetylmethionine.
Location(AA) Modifications Resource
Location(AA) Modification Resource
59Phosphotyrosine(Jak)HMM predict
79Phosphotyrosine(EGFR)HMM predict
190Phosphotyrosine(SRC)HMM predict
233Phosphotyrosine(Jak)HMM predict
237O-linkedHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_003132
  • Location:chr1 11037235-11042677
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Fos K562GSE19551 11042616 11043133 517 197
H3ac HepG2E 11043107 11043755 648 754
H3ac HepG2E 11044263 11044588 325 1748
H3ac HepG2E 11045481 11045857 376 2992
Myc hESGSE17917 11042597 11042844 247 43
PHF8 293TGSE20725 11042068 11043469 1401 91
Rb QuiescentGSE19898 11043633 11043739 106 1009
Rb shRbSenescenceGSE19898 11042671 11042945 274 131
p130 SenescentGSE19898 11042946 11043198 252 395
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
ER MCF7GSE19013 11035874 11036591 717 1003
NRSF JurkatGSE13047 11035540 11037600 2060 666
NRSF mAbJurkat 11035193 11037047 1854 1116
NRSF-mono JurkatQuESTdata 11035596 11037751 2155 562
NRSF-poly JurkatQuESTdata 11035394 11037767 2373 655
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 11037161 11037739 578 0
CTCF G2GSE9613 11042163 11042926 763 0
H3ac HepG2E 11041238 11041522 284 0
PHF8 HeLaGSE20725 11041331 11043551 2220 0
TFAP2C MCF7GSE21234 11041066 11041518 452 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-let-7a hsa-let-7a-1 9 20835247
hsa-let-7a hsa-let-7a-2 11 20835247
hsa-let-7a hsa-let-7a-3 22 20835247
hsa-let-7a* hsa-let-7a-1 9 20835247
hsa-let-7a* hsa-let-7a-3 22 20835247
hsa-let-7b hsa-let-7b 22 20835247
hsa-let-7b* hsa-let-7b 22 20835247
hsa-let-7c hsa-let-7c 21 20835247
hsa-let-7c* hsa-let-7c 21 20835247
hsa-let-7d hsa-let-7d 9 20835247
hsa-let-7d* hsa-let-7d 9 20835247
hsa-let-7e hsa-let-7e 19 20835247
hsa-let-7e* hsa-let-7e 19 20835247
hsa-let-7f hsa-let-7f-1 9 20835247
hsa-let-7f hsa-let-7f-2 X 20835247
hsa-let-7f-1* hsa-let-7f-1 9 20835247
hsa-let-7f-2* hsa-let-7f-2 X 20835247
hsa-let-7g hsa-let-7g 3 20835247
hsa-let-7g* hsa-let-7g 3 20835247
hsa-let-7i hsa-let-7i 12 20835247
hsa-let-7i* hsa-let-7i 12 20835247
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018