AutismKB 2.0

Annotation Detail for STAT1


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Basic Information Top
Gene Symbol:STAT1 ( DKFZp686B04100,ISGF-3,STAT91 )
Gene Full Name: signal transducer and activator of transcription 1, 91kDa
Band: 2q32.2
Quick LinksEntrez ID:6772; OMIM: 600555; Uniprot ID:STAT1_HUMAN; ENSEMBL ID: ENSG00000115415; HGNC ID: 11362
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
701Phosphotyrosine; by JAK.
727Phosphoserine; by MAPK14.
Location(AA) Modifications Resource
701Phosphotyrosine (by JAK).Swiss-Prot 53.0
701Phosphotyrosine (Src;EGFR;JAK)Phospho.ELM 6.0
727Phosphoserine.Swiss-Prot 53.0
727PhosphoserinePhospho.ELM 6.0
Location(AA) Modification Resource
62Phosphoserine(ATM)HMM predict
203Phosphotyrosine(Jak)HMM predict
222N-linkedHMM predict
287SulfotyrosineHMM predict
397N-linkedHMM predict
460N-linkedHMM predict
462Phosphoserine(ATM)HMM predict
530N-linkedHMM predict
701Phosphotyrosine(EGFR)HMM predict
701Phosphotyrosine(INSR)HMM predict
701Phosphotyrosine(Jak)HMM predict
719Phosphothreonine(PKC)HMM predict
727Phosphoserine(MAPK)HMM predict
747MethionineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_139266
  • Location:chr2 191548509-191587180
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP JurkatGSE17954 191592546 191596995 4449 7590
CBP T30-glioblastomaGSE21026 191586746 191587818 1072 102
CBP T30-glioblastomaGSE21026 191593082 191594296 1214 6509
CTCF G2GSE9613 191593173 191593442 269 6127
E2F4 G0GSE7516 191593173 191593646 473 6229
ETS1 JurkatGSE17954 191586641 191587859 1218 70
ETS1 JurkatGSE17954 191592993 191594147 1154 6390
FOXA1 MCF7GSE15244 191587204 191587810 606 327
Fos K562GSE19551 191587051 191587558 507 124
H3ac HepG2E 191593476 191595018 1542 7067
HIF1 HypoHepG2 191593173 191594247 1074 6530
HIF1 NormHepG2 191593173 191594539 1366 6676
KLF4 hESGSE17917 191593138 191593366 228 6072
LIN9 G0GSE7516 191593173 191593782 609 6297
LIN9 SGSE7516 191593173 191593857 684 6335
NFkBII GM10847GSE19485 191592308 191594713 2405 6330
NFkBII GM12878GSE19485 191585738 191589179 3441 278
NFkBII GM12892GSE19485 191585882 191589073 3191 297
NFkBII GM15510GSE19485 191585799 191589074 3275 256
NFkBII GM18526GSE19485 191591100 191596628 5528 6684
Nanog ESGSE20650 191593168 191593641 473 6224
PHF8 HeLaGSE20725 191593108 191594171 1063 6459
STAT1 HeLaGSE12783 191592679 191595185 2506 6752
TAF k562GSE8489 191594566 191595018 452 7612
TAFII hESGSE17917 191586841 191587634 793 57
TFAP2C MCF7GSE21234 191593125 191593639 514 6202
USF1 HepG2E 191587468 191588521 1053 814
USF1 HepG2E 191591273 191591596 323 4254
USF1 HepG2E 191593173 191594318 1145 6565
USF2 HepG2E 191593229 191594283 1054 6576
hScc1 BcellGSE12603 191593173 191593476 303 6144
hScc1 G2GSE9613 191593173 191593442 269 6127
p130 QuiescentGSE19898 191593109 191593862 753 6305
p130 SenescentGSE19898 191593087 191593780 693 6253
p130 shRbSenescentGSE19898 191593051 191593872 821 6281
p130 G0GSE7516 191593173 191593782 609 6297
p130 SGSE7516 191593173 191593476 303 6144
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 191550667 191550851 184 0
CTCF G2GSE9613 191553400 191553686 286 0
CTCF G2GSE9613 191559300 191559620 320 0
CTCF G2GSE9613 191568700 191569891 1191 0
CTCF G2GSE9613 191586806 191587131 325 0
FOXA1 MCF7GSE15244 191553012 191554099 1087 0
FoxA1 MCF7MACSdata 191553351 191553652 301 0
FoxA1 MCF7MACSdata 191553685 191553817 132 0
H3K4me3 colorectalcancer 191585416 191586623 1207 0
H3ac HepG2E 191586246 191586841 595 0
NFkBII GM18526GSE19485 191585244 191588924 3680 0
P300 T30-glioblastomaGSE21026 191586442 191587841 1399 0
PHF8 HeLaGSE20725 191586489 191587751 1262 0
Pol2 GM12878GSE19551 191550507 191550917 410 0
Pol2 GM12878GSE19551 191583799 191588257 4458 0
RARA MCF7GSE15244 191553012 191553874 862 0
STAT1 HeLaGSE12783 191585274 191588354 3080 0
TFAP2C MCF7GSE21234 191552848 191553674 826 0
TFAP2C MCF7GSE21234 191569397 191569718 321 0
hScc1 BcellGSE12603 191586841 191587435 594 0
p63 keratinocytesGSE17611 191573695 191574710 1015 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-145 hsa-mir-145 5 20098684
hsa-miR-145* hsa-mir-145 5 20098684
hsa-miR-146a hsa-mir-146a 5 20850013
hsa-miR-146a* hsa-mir-146a 5 20850013
hsa-miR-155 hsa-mir-155 21 20950585
hsa-miR-155 hsa-mir-155 21 20329552
hsa-miR-155* hsa-mir-155 21 20950585
hsa-miR-155* hsa-mir-155 21 20329552
hsa-miR-16 hsa-mir-16-1 13 20329552
hsa-miR-16 hsa-mir-16-2 3 20329552
hsa-miR-181a hsa-mir-181a-2 9 20329552
hsa-miR-181a hsa-mir-181a-1 1 20329552
hsa-miR-181a* hsa-mir-181a-1 1 20329552
hsa-miR-181a-2* hsa-mir-181a-2 9 20329552
hsa-miR-181b hsa-mir-181b-1 1 20329552
hsa-miR-181b hsa-mir-181b-2 9 20329552
hsa-miR-181c hsa-mir-181c 19 20329552
hsa-miR-181c* hsa-mir-181c 19 20329552
hsa-miR-181d hsa-mir-181d 19 20329552
hsa-miR-221 hsa-mir-221 X 20428775
hsa-miR-221* hsa-mir-221 X 20428775
hsa-miR-222 hsa-mir-222 X 20428775
hsa-miR-222* hsa-mir-222 X 20428775
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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