Annotation Detail for STK4
Basic Information Top
| Gene Symbol: | STK4 ( DKFZp686A2068,KRS2,MST1,YSK3 ) |
|---|---|
| Gene Full Name: | serine/threonine kinase 4 |
| Band: | 20q13.12 |
| Quick Links | Entrez ID:6789; OMIM: 604965; Uniprot ID:STK4_HUMAN; ENSEMBL ID: ENSG00000101109; HGNC ID: 11408 |
| Relate to Another Database: | SFARIGene; denovo-db |
| Location(AA) | Modification | |
|---|---|---|
| 1 | N-acetylmethionine. | |
| 3 | Phosphothreonine. | |
| 40 | Phosphoserine. | |
| 41 | Phosphotyrosine. | |
| 175 | Phosphothreonine. | |
| 177 | Phosphothreonine. | |
| 183 | Phosphothreonine; by autocatalysis. | |
| 265 | Phosphoserine. | |
| 320 | Phosphoserine. | |
| 327 | Phosphoserine. | |
| 329 | Phosphothreonine. | |
| 340 | Phosphothreonine. | |
| 353 | Phosphothreonine. | |
| 360 | Phosphothreonine. | |
| 367 | Phosphothreonine. | |
| 380 | Phosphothreonine. | |
| 387 | Phosphothreonine. | |
| 394 | Phosphoserine. | |
| 410 | Phosphoserine. | |
| 414 | Phosphoserine. | |
| 422 | Phosphoserine. | |
| 433 | Phosphotyrosine. | |
| 438 | Phosphoserine. | |
| Location(AA) | Modifications | Resource |
|---|---|---|
| 183 | Phosphothreonine (by autocatalysis). | Swiss-Prot 53.0 |
| 183 | Phosphothreonine (MST1) | Phospho.ELM 6.0 |
| 320 | Phosphoserine (By similarity). | Swiss-Prot 53.0 |
| 433 | Phosphotyrosine. | Swiss-Prot 53.0 |
| Location(AA) | Modification | Resource |
|---|---|---|
| 21 | Phosphoserine(CK1) | HMM predict |
| 41 | Phosphotyrosine(INSR) | HMM predict |
| 41 | Phosphotyrosine(EGFR) | HMM predict |
| 41 | Phosphotyrosine(SRC) | HMM predict |
| 118 | N-linked | HMM predict |
| 122 | Phosphothreonine(CK2) | HMM predict |
| 243 | Phosphothreonine(PKC) | HMM predict |
| 253 | N-linked | HMM predict |
| 307 | Phosphoserine(PKG) | HMM predict |
| 320 | Phosphoserine(CK1) | HMM predict |
| 421 | N-linked | HMM predict |
- RefSeq ID: NM_006282
- Location:chr20 43028533-43142004
- strand:+
| Transcrip Factors | Experimental Cell | Database | TF Binding Start | TF Binding End | TF Binding Length | The Distance to Gene |
|---|---|---|---|---|---|---|
| CTCF | CD4 | GSE12889 | 43028256 | 43028676 | 420 | 68 |
| CTCF | CD4 | SISSRdata | 43028256 | 43028676 | 420 | 68 |
| CTCF | G2 | GSE9613 | 43028030 | 43028748 | 718 | 145 |
| H3ac | HepG2 | E | 43028030 | 43028318 | 288 | 360 |
| Myc | K562 | GSE19551 | 43028107 | 43028805 | 698 | 78 |
| PHF8 | 293T | GSE20725 | 43027780 | 43029157 | 1377 | 65 |
| TFAP2C | MCF7 | GSE21234 | 43027898 | 43028491 | 593 | 339 |
| USF1 | HepG2 | E | 43027408 | 43027694 | 286 | 983 |
| p130 | shRbQuiescent | GSE19898 | 43028094 | 43028723 | 629 | 125 |
| Transcrip Factors | Experimental Cell | Database | TF Binding Start | TF Binding End | TF Binding Length | The Distance to Gene |
|---|---|---|---|---|---|---|
| Rb | shRbSenescence | GSE19898 | 43142406 | 43142569 | 163 | 483 |
| Transcrip Factors | Experimental Cell | Database | TF Binding Start | TF Binding End | TF Binding Length | The Distance to Gene |
|---|---|---|---|---|---|---|
| CTCF | CD4 | GSE12889 | 43106166 | 43106436 | 270 | 0 |
| CTCF | CD4 | SISSRdata | 43106166 | 43106436 | 270 | 0 |
| CTCF | G2 | GSE9613 | 43073008 | 43073471 | 463 | 0 |
| CTCF | G2 | GSE9613 | 43105921 | 43106396 | 475 | 0 |
| ETS1 | Jurkat | GSE17954 | 43028063 | 43029069 | 1006 | 0 |
| Fos | K562 | GSE19551 | 43133228 | 43133937 | 709 | 0 |
| H3K4me3 | colorectal | cancer | 43028748 | 43029870 | 1122 | 0 |
| H3ac | HepG2 | E | 43028568 | 43029870 | 1302 | 0 |
| H3ac | HepG2 | E | 43030509 | 43030890 | 381 | 0 |
| H3ac | HepG2 | E | 43031301 | 43031524 | 223 | 0 |
| H3ac | HepG2 | E | 43139218 | 43139427 | 209 | 0 |
| Myc | K562 | GSE19551 | 43041353 | 43041712 | 359 | 0 |
| Myc | K562 | GSE19551 | 43098172 | 43098649 | 477 | 0 |
| P300 | T30-glioblastoma | GSE21026 | 43103302 | 43104895 | 1593 | 0 |
| P300 | T30-glioblastoma | GSE21026 | 43122903 | 43124056 | 1153 | 0 |
| PHF8 | HeLa | GSE20725 | 43027860 | 43029342 | 1482 | 0 |
| Rb | Growing | GSE19898 | 43028571 | 43028847 | 276 | 0 |
| Rb | Quiescent | GSE19898 | 43028356 | 43028967 | 611 | 0 |
| Rb | Senescent | GSE19898 | 43028217 | 43029042 | 825 | 0 |
| Rb | shRbSenescence | GSE19898 | 43028581 | 43028983 | 402 | 0 |
| Stat6 | IL-4-hr4 | GSE17850 | 43041018 | 43041774 | 756 | 0 |
| USF1 | HepG2 | E | 43028030 | 43029870 | 1840 | 0 |
| USF1 | HepG2 | E | 43030509 | 43030890 | 381 | 0 |
| USF2 | HepG2 | E | 43028030 | 43029807 | 1777 | 0 |
| hScc1 | Bcell | GSE12603 | 43028241 | 43028906 | 665 | 0 |
| hScc1 | Bcell | GSE12603 | 43106105 | 43106396 | 291 | 0 |
| hScc1 | CdLS | GSE12603 | 43106001 | 43106396 | 395 | 0 |
| hScc1 | G2 | GSE9613 | 43072937 | 43073541 | 604 | 0 |
| hScc1 | G2 | GSE9613 | 43105921 | 43106396 | 475 | 0 |
| p130 | shRbSenescent | GSE19898 | 43028273 | 43028933 | 660 | 0 |
| p63 | keratinocytes | GSE17611 | 43061675 | 43062575 | 900 | 0 |
| Micro RNA Name | Stem Loop Name | The chromosome that miRNA located | Publication |
|---|---|---|---|
| hsa-miR-1 | hsa-mir-1-2 | 18 | 15685193 |
| hsa-miR-1 | hsa-mir-1-1 | 20 | 15685193 |
| hsa-miR-1 | hsa-mir-1-2 | 18 | 15685193 |
| hsa-miR-1 | hsa-mir-1-1 | 20 | 15685193 |
| hsa-miR-124 | hsa-mir-124-1 | 8 | 15685193 |
| hsa-miR-124 | hsa-mir-124-2 | 8 | 15685193 |
| hsa-miR-124 | hsa-mir-124-3 | 20 | 15685193 |
| hsa-miR-124 | hsa-mir-124-1 | 8 | 15685193 |
| hsa-miR-124 | hsa-mir-124-2 | 8 | 15685193 |
| hsa-miR-124 | hsa-mir-124-3 | 20 | 15685193 |
| hsa-miR-373 | hsa-mir-373 | 19 | 15685193 |
| hsa-miR-373 | hsa-mir-373 | 19 | 15685193 |
| hsa-miR-373* | hsa-mir-373 | 19 | 15685193 |
| hsa-miR-373* | hsa-mir-373 | 19 | 15685193 |
| ID in Tarbase | Data Type | Support Type | miRNA | Gene | Direct Support | Publication |
|---|---|---|---|---|---|---|
| 647 | Unknown | MicroArray | miR-373 | STK4 | n_a | 15685193 |
| Ensembl | Protein Type | Differentially expressed in | Pathology or Event | Mis Regulation | Gene Expression | Tumour Involvement |
| ENSG00000101109 | n_a | n_a | n_a | n_a | n_a |
Cis-Nats regulation